Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels

Bibliographic Details
Main Author: Siani, Antônio Carlos
Publication Date: 2014
Other Authors: Nakamura, Marcos Jun, Santos, Daniel Silva dos, Mazzei, José Luiz, Nascimento, Adriana Clacidio do, Valente, Lígia Maria Marino
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/40348
Summary: Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
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spelling Siani, Antônio CarlosNakamura, Marcos JunSantos, Daniel Silva dosMazzei, José LuizNascimento, Adriana Clacidio doValente, Lígia Maria Marino2020-03-17T13:36:37Z2020-03-17T13:36:37Z2014SIANI, Antônio Carlos et al. Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels. Pharmacognosy Magazine, v. 10, n. 38, p. 1-8, Apr./June 2014.0973-1296https://www.arca.fiocruz.br/handle/icict/4034810.4103/0973-1296.133236engEfficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.This study assessed the extraction efficiency of ursolic (UA) and oleanolic acids (OA), as well as the total phenols in aqueous and hydroethanolic extracts of dry apple peels at room temperature. Materials and Methods: After running preliminary assays on decoctions and tinctures (ethanol: water 7:3 v/v), the extracts from dried apple (cv. Fuji) peels were obtained by static maceration over varied intervals (2 to 180 days). The UA and OA content in the extracts was quantified by High Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD) with a reversed phase column and isocratic elution (CH3CN/H2O/H3PO4) against calibration curves (R2 > 0.9995). The total phenol content in the extracts was evaluated spectrophotometrically at 760 nm using the Folin-Ciocalteau method referencing gallic acid. Results: UA and OA in the hydroethanolic extracts ranged from 3.63‑6.12 mg/g and 2.12‑3.30 mg/g, corresponding to 1.72-3.07 and 1.00-1.66 mg/g in the raw material, respectively. Higher values of triterpene acid content corresponded to maceration periods of 10 or 30 days. The residual phenol and polyphenol content ranged from 6.97 to 11.6 mg/g. The UA and OA yields, as well as the total phenol content, versus the maceration time were plotted in Control Charts within confidence intervals (95%) and were unaffected during the assayed period. Conclusion: Apple peel tinctures from 10% solids obtained at room temperature exhibited the highest content of triterpene acids when employing a maceration period of 10 to 30 days. Extracts prepared using this procedure contained an average of 7.33 mg/g of total triterpene acids and 10.6 mg/g phenolic compounds. These results establish supporting data for apple peel tinctures and their derived phytopharmaceuticals that are standardized on the ursolic-oleanolic acid content.Apple PeelMalus DomesticaOleanolic AcidTotal PhenolsUrsolic Acidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/40348/1/license.txt4567a98700b61d3191d4763a7ff1bb4dMD51ORIGINAL(Siani et al 2014) Efficiency and selectivity of triterpene acid extraction.pdf(Siani et al 2014) Efficiency and selectivity of triterpene acid extraction.pdfapplication/pdf981800https://www.arca.fiocruz.br/bitstream/icict/40348/2/%28Siani%20et%20al%202014%29%20Efficiency%20and%20selectivity%20of%20triterpene%20acid%20extraction.pdf06429044e4cda72b5a1bb8714ba18a93MD52TEXT(Siani et al 2014) Efficiency and selectivity of triterpene acid extraction.pdf.txt(Siani et al 2014) Efficiency and selectivity of triterpene acid extraction.pdf.txtExtracted texttext/plain32831https://www.arca.fiocruz.br/bitstream/icict/40348/3/%28Siani%20et%20al%202014%29%20Efficiency%20and%20selectivity%20of%20triterpene%20acid%20extraction.pdf.txt8192561c886984961c739af1e5b9cbceMD53icict/403482020-03-18 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dc.title.pt_BR.fl_str_mv Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
title Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
spellingShingle Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
Siani, Antônio Carlos
Apple Peel
Malus Domestica
Oleanolic Acid
Total Phenols
Ursolic Acid
title_short Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
title_full Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
title_fullStr Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
title_full_unstemmed Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
title_sort Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels
author Siani, Antônio Carlos
author_facet Siani, Antônio Carlos
Nakamura, Marcos Jun
Santos, Daniel Silva dos
Mazzei, José Luiz
Nascimento, Adriana Clacidio do
Valente, Lígia Maria Marino
author_role author
author2 Nakamura, Marcos Jun
Santos, Daniel Silva dos
Mazzei, José Luiz
Nascimento, Adriana Clacidio do
Valente, Lígia Maria Marino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Siani, Antônio Carlos
Nakamura, Marcos Jun
Santos, Daniel Silva dos
Mazzei, José Luiz
Nascimento, Adriana Clacidio do
Valente, Lígia Maria Marino
dc.subject.en.pt_BR.fl_str_mv Apple Peel
Malus Domestica
Oleanolic Acid
Total Phenols
Ursolic Acid
topic Apple Peel
Malus Domestica
Oleanolic Acid
Total Phenols
Ursolic Acid
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2020-03-17T13:36:37Z
dc.date.available.fl_str_mv 2020-03-17T13:36:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SIANI, Antônio Carlos et al. Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels. Pharmacognosy Magazine, v. 10, n. 38, p. 1-8, Apr./June 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40348
dc.identifier.issn.pt_BR.fl_str_mv 0973-1296
dc.identifier.doi.pt_BR.fl_str_mv 10.4103/0973-1296.133236
identifier_str_mv SIANI, Antônio Carlos et al. Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels. Pharmacognosy Magazine, v. 10, n. 38, p. 1-8, Apr./June 2014.
0973-1296
10.4103/0973-1296.133236
url https://www.arca.fiocruz.br/handle/icict/40348
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40348/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40348/2/%28Siani%20et%20al%202014%29%20Efficiency%20and%20selectivity%20of%20triterpene%20acid%20extraction.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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