Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/6893 |
Resumo: | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil |
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Francisco, Amanda FortesVieira, Paula Melo de AbreuArantes, Jerusa MarildaSilva, MaisaPedrosa, Maria LúciaSantos, Silvana Maria ElóiMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deAraújo, Márcio Sobreira SilvaTafuri, Washington LuizCarneiro, Cláudia Martins2013-09-13T19:16:25Z2013-09-13T19:16:25Z2010FRANCISCO, Amanda Fortes et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Rep. 2010;15(4):185-90https://www.arca.fiocruz.br/handle/icict/689310.1179/174329210X12650506623528engIncrease of reactive oxygen species by desferrioxamine during experimental Chagas' diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, BrazilFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Bioquímica e Biologia Molecular. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Bioquímica e Biologia Molecular. Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedêutica Complementar. Belo Horizonte, MG, BrazilFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilFundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil/Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, BrazilOxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant system in order to provide an overview of the mechanism of action of the iron chelator desferrioxamine (DFO). The study population comprised 48 male Swiss mice, half of which were treated daily by intraperitoneal injection of DFO over a 35-day period, while half were administered sterile water in a similar manner. On the 14th day of the experiment, 12 DFO-treated mice and an equal number of untreated mice were experimentally infected with Trypanosoma cruzi. Serum concentrations of nitric oxide and superoxide dismutase and hepatic levels of total glutathione, thiobarbituric acid reactive species and protein carbonyl, were determined on days 0, 7, 14 and 21 post-infection. The results obtained revealed that DFO enhances antioxidant activity in the host but also increases oxidative stress, indicating that the mode of action of the drug involves a positive contribution to the host together with an effect that is not beneficial to the parasitedesferrioxamineoxidativestressChagas’ diseaseTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL44.2010.pdf44.2010.pdfapplication/pdf173860https://www.arca.fiocruz.br/bitstream/icict/6893/1/44.2010.pdf9d646519e472a9f612b950049283708aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6893/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT44.2010.pdf.txt44.2010.pdf.txtExtracted texttext/plain25537https://www.arca.fiocruz.br/bitstream/icict/6893/5/44.2010.pdf.txt73b4f519196d151b944db19722d6cf8dMD55THUMBNAIL44.2010.pdf.jpg44.2010.pdf.jpgGenerated Thumbnailimage/jpeg2545https://www.arca.fiocruz.br/bitstream/icict/6893/4/44.2010.pdf.jpg244625df888b7ae30b5bee8d5aba7d43MD54icict/68932018-04-26 11:38:50.138oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-26T14:38:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| title |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| spellingShingle |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease Francisco, Amanda Fortes desferrioxamine oxidativestress Chagas’ disease Trypanosoma cruzi |
| title_short |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| title_full |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| title_fullStr |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| title_full_unstemmed |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| title_sort |
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease |
| author |
Francisco, Amanda Fortes |
| author_facet |
Francisco, Amanda Fortes Vieira, Paula Melo de Abreu Arantes, Jerusa Marilda Silva, Maisa Pedrosa, Maria Lúcia Santos, Silvana Maria Elói Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Araújo, Márcio Sobreira Silva Tafuri, Washington Luiz Carneiro, Cláudia Martins |
| author_role |
author |
| author2 |
Vieira, Paula Melo de Abreu Arantes, Jerusa Marilda Silva, Maisa Pedrosa, Maria Lúcia Santos, Silvana Maria Elói Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Araújo, Márcio Sobreira Silva Tafuri, Washington Luiz Carneiro, Cláudia Martins |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Francisco, Amanda Fortes Vieira, Paula Melo de Abreu Arantes, Jerusa Marilda Silva, Maisa Pedrosa, Maria Lúcia Santos, Silvana Maria Elói Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Araújo, Márcio Sobreira Silva Tafuri, Washington Luiz Carneiro, Cláudia Martins |
| dc.subject.en.pt_BR.fl_str_mv |
desferrioxamine oxidativestress Chagas’ disease Trypanosoma cruzi |
| topic |
desferrioxamine oxidativestress Chagas’ disease Trypanosoma cruzi |
| description |
Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil |
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2010 |
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2010 |
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2013-09-13T19:16:25Z |
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2013-09-13T19:16:25Z |
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FRANCISCO, Amanda Fortes et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Rep. 2010;15(4):185-90 |
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https://www.arca.fiocruz.br/handle/icict/6893 |
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FRANCISCO, Amanda Fortes et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Rep. 2010;15(4):185-90 10.1179/174329210X12650506623528 |
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