Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons

Detalhes bibliográficos
Autor(a) principal: Fonseca, Cristina Toscano
Data de Publicação: 2015
Outros Autores: Oliveira, Sergio Costa, Alves, Clarice Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12560
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Ministério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, Brasil
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spelling Fonseca, Cristina ToscanoOliveira, Sergio CostaAlves, Clarice Carvalho2016-01-19T17:23:17Z2016-01-19T17:23:17Z2015FONSECA, Cristina Toscano; OLIVEIRA, Sergio Costa; ALVES, Clarice Carvalho. Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?. Front Immunol. , vol. 6, p. 95, 20151664-3224https://www.arca.fiocruz.br/handle/icict/1256010.3389/fimmu.2015.00095.engFrontiers Research FoundationEliminating Schistosomes through Vaccination: What are the Best Immune Weaponsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Ministério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, BrasilMinistério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrasilThe successful development of vaccines depends on the knowledge of the immunological mechanisms associated with the elimination of the pathogen. In the case of schistosomes, its complex life cycle and the mechanisms developed to evade host immune system, turns the development of a vaccine against the disease into a very difficult task. Identifying the immunological effector mechanisms involved in parasite attrition and the major targets for its response is a key step to formulate an effective vaccine. Recent studies have described some promising antigens to compose a subunit vaccine and have pointed to some immune factors that play a role in parasite elimination. Here, we review the immune components and effector mechanisms associated with the protective immunity induced by those vaccine candidates and the lessons we have learned from the studies of the acquired resistance to infection in humans. We will also discuss the immune factors that correlate with protschistosome vaccineprotective immunityschistosomiasiseffector mechanismsimmune responseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12560/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEliminating Schistosomes through Vaccination.pdfEliminating Schistosomes through Vaccination.pdfapplication/pdf5680710https://www.arca.fiocruz.br/bitstream/icict/12560/2/Eliminating%20Schistosomes%20through%20Vaccination.pdf6554db71fa4c1eab22b83706cba2fbb2MD52TEXTEliminating Schistosomes through Vaccination.pdf.txtEliminating Schistosomes through Vaccination.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
title Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
spellingShingle Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
Fonseca, Cristina Toscano
schistosome vaccine
protective immunity
schistosomiasis
effector mechanisms
immune response
title_short Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
title_full Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
title_fullStr Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
title_full_unstemmed Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
title_sort Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons
author Fonseca, Cristina Toscano
author_facet Fonseca, Cristina Toscano
Oliveira, Sergio Costa
Alves, Clarice Carvalho
author_role author
author2 Oliveira, Sergio Costa
Alves, Clarice Carvalho
author2_role author
author
dc.contributor.author.fl_str_mv Fonseca, Cristina Toscano
Oliveira, Sergio Costa
Alves, Clarice Carvalho
dc.subject.en.pt_BR.fl_str_mv schistosome vaccine
protective immunity
schistosomiasis
effector mechanisms
immune response
topic schistosome vaccine
protective immunity
schistosomiasis
effector mechanisms
immune response
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Ministério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-01-19T17:23:17Z
dc.date.available.fl_str_mv 2016-01-19T17:23:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Cristina Toscano; OLIVEIRA, Sergio Costa; ALVES, Clarice Carvalho. Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?. Front Immunol. , vol. 6, p. 95, 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12560
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2015.00095.
identifier_str_mv FONSECA, Cristina Toscano; OLIVEIRA, Sergio Costa; ALVES, Clarice Carvalho. Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?. Front Immunol. , vol. 6, p. 95, 2015
1664-3224
10.3389/fimmu.2015.00095.
url https://www.arca.fiocruz.br/handle/icict/12560
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12560/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/12560/2/Eliminating%20Schistosomes%20through%20Vaccination.pdf
https://www.arca.fiocruz.br/bitstream/icict/12560/3/Eliminating%20Schistosomes%20through%20Vaccination.pdf.txt
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