Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Silva, W. Miranda
Data de Publicação: 1988
Outros Autores: Castro, B. Galvão, Almeida, M. G. Bonecini, Daniel Ribeiro, Claudio Tadeu, Sion, F. S., Sá, C. A. Moraes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43060
Resumo: Alterações imunológicas na Síndrome de Imunodeficiência Adquirida em pacientes do Rio de Janeiro, Brasil. O perfil imunológico de 15 pacientes com Síndrome de Imunodeficiência Adquirida (AIDS) e 11 com Síndrome de Linfadenipatia Crônica, foram estudados. Os pacientes com AIDS mostraram reduzida percentagem de linfócitos T (CD3) totais e T auxiliares (CD4), aumento relativo no número de linfócito T-supressores (CD8) e uma marcante inversão na relação T-auxiliares/supressores (CD4/CD8). A resposta linfoproliferativa para PHA, ConA, PPD e PWN, estava diminuída. Foi também observado hipergamaglobulinemia e níveis aumentados de complexos imunes circulantes. Os pacientes com Síndrome de Linfadenopatia Crônica também mostraram importantes alterações imunológicas, mas não tão intensas como nos de AIDS. Estes dados são similares aos observados nos Estados Unidos e na Europa.
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spelling Silva, W. MirandaCastro, B. GalvãoAlmeida, M. G. BoneciniDaniel Ribeiro, Claudio TadeuSion, F. S.Sá, C. A. Moraes de2020-08-29T17:58:59Z2020-08-29T17:58:59Z1988SILVA, W. Miranda et al. Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil. Memórias do Instituto do Rio de Janeiro, v. 83, n. 3, p. 305-322, jul./set. 1988.0074-0276https://www.arca.fiocruz.br/handle/icict/4306010.1590/S0074-027619880003000071678-8060Alterações imunológicas na Síndrome de Imunodeficiência Adquirida em pacientes do Rio de Janeiro, Brasil. O perfil imunológico de 15 pacientes com Síndrome de Imunodeficiência Adquirida (AIDS) e 11 com Síndrome de Linfadenipatia Crônica, foram estudados. Os pacientes com AIDS mostraram reduzida percentagem de linfócitos T (CD3) totais e T auxiliares (CD4), aumento relativo no número de linfócito T-supressores (CD8) e uma marcante inversão na relação T-auxiliares/supressores (CD4/CD8). A resposta linfoproliferativa para PHA, ConA, PPD e PWN, estava diminuída. Foi também observado hipergamaglobulinemia e níveis aumentados de complexos imunes circulantes. Os pacientes com Síndrome de Linfadenopatia Crônica também mostraram importantes alterações imunológicas, mas não tão intensas como nos de AIDS. Estes dados são similares aos observados nos Estados Unidos e na Europa.The immunoloical profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numbers of T-suppressor-cytotoxic (CD8) cells and a marked inversion of T-helper-inducer/suppressor-cytotoxic (CD4/CD8) ratio. Lymphoproliferative responses to PHA, ConA, PPD and PWM were diminished. Hypergamaglobulinemia and high levels of circulating immune complexes were also found. The CLAS patients also showed important immunological alterations, but not so intense as those with AIDS. These data seems to be similar to those observed in other parts of the world.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO Collaborating Centre of AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO Collaborating Centre of AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO Collaborating Centre of AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, WHO Collaborating Centre of AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brasil.engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Alterações humoraisLinfócitoLynphocyteHumoral alterationsImmunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43060/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWMirandaSilva_ClaudioTDRibeiro_etal_IOC_1988.pdfWMirandaSilva_ClaudioTDRibeiro_etal_IOC_1988.pdfapplication/pdf301328https://www.arca.fiocruz.br/bitstream/icict/43060/2/WMirandaSilva_ClaudioTDRibeiro_etal_IOC_1988.pdf634dada1da9bffb28e29ac020e8fee3dMD52TEXTWMirandaSilva_ClaudioTDRibeiro_etal_IOC_1988.pdf.txtWMirandaSilva_ClaudioTDRibeiro_etal_IOC_1988.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
title Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
spellingShingle Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
Silva, W. Miranda
Alterações humorais
Linfócito
Lynphocyte
Humoral alterations
title_short Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
title_full Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
title_fullStr Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
title_full_unstemmed Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
title_sort Immunological abnormalities of acquired immunodificiency syndrome and related disorders in patients from Rio de Janeiro, Brazil
author Silva, W. Miranda
author_facet Silva, W. Miranda
Castro, B. Galvão
Almeida, M. G. Bonecini
Daniel Ribeiro, Claudio Tadeu
Sion, F. S.
Sá, C. A. Moraes de
author_role author
author2 Castro, B. Galvão
Almeida, M. G. Bonecini
Daniel Ribeiro, Claudio Tadeu
Sion, F. S.
Sá, C. A. Moraes de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, W. Miranda
Castro, B. Galvão
Almeida, M. G. Bonecini
Daniel Ribeiro, Claudio Tadeu
Sion, F. S.
Sá, C. A. Moraes de
dc.subject.other.pt_BR.fl_str_mv Alterações humorais
Linfócito
topic Alterações humorais
Linfócito
Lynphocyte
Humoral alterations
dc.subject.en.pt_BR.fl_str_mv Lynphocyte
Humoral alterations
description Alterações imunológicas na Síndrome de Imunodeficiência Adquirida em pacientes do Rio de Janeiro, Brasil. O perfil imunológico de 15 pacientes com Síndrome de Imunodeficiência Adquirida (AIDS) e 11 com Síndrome de Linfadenipatia Crônica, foram estudados. Os pacientes com AIDS mostraram reduzida percentagem de linfócitos T (CD3) totais e T auxiliares (CD4), aumento relativo no número de linfócito T-supressores (CD8) e uma marcante inversão na relação T-auxiliares/supressores (CD4/CD8). A resposta linfoproliferativa para PHA, ConA, PPD e PWN, estava diminuída. Foi também observado hipergamaglobulinemia e níveis aumentados de complexos imunes circulantes. Os pacientes com Síndrome de Linfadenopatia Crônica também mostraram importantes alterações imunológicas, mas não tão intensas como nos de AIDS. Estes dados são similares aos observados nos Estados Unidos e na Europa.
publishDate 1988
dc.date.issued.fl_str_mv 1988
dc.date.accessioned.fl_str_mv 2020-08-29T17:58:59Z
dc.date.available.fl_str_mv 2020-08-29T17:58:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, W. Miranda et al. Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil. Memórias do Instituto do Rio de Janeiro, v. 83, n. 3, p. 305-322, jul./set. 1988.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43060
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761988000300007
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SILVA, W. Miranda et al. Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil. Memórias do Instituto do Rio de Janeiro, v. 83, n. 3, p. 305-322, jul./set. 1988.
0074-0276
10.1590/S0074-02761988000300007
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43060
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language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
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