Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Lopes, Denielle de Souza
Data de Publicação: 2020
Outros Autores: Santos, Uener Ribeiro dos, Anjos, Danielle Oliveira dos, Silva Júnior, Lauro José Caires da, Paula, Vanderlúcia Fonseca de, Santos, Marcos André Vannier, Jardim, Izaltina Silva, Gomes, Thiago Castro, Pirovani, Carlos Priminho, Santos, Jane Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42531
Resumo: Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.
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spelling Lopes, Denielle de SouzaSantos, Uener Ribeiro dosAnjos, Danielle Oliveira dosSilva Júnior, Lauro José Caires daPaula, Vanderlúcia Fonseca deSantos, Marcos André VannierJardim, Izaltina SilvaGomes, Thiago CastroPirovani, Carlos PriminhoSantos, Jane Lima2020-08-04T17:43:21Z2020-08-04T17:43:21Z2020LOPES, Danielle de Sousa et al. Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis. Front. Cell. Infect. Microbiol, v. 10. Article 306, July 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4253110.3389/fcimb.2020.00306engFrontiers MediaLeishmania amazonensisLeishmanioseQuimioterapiaTrichodermaLeishmanicidaLeishmania amazonensisTrichodermaChemotherapyLeishmanicidalLeishmaniasisLeishmania amazonensisEthanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Estadual Do Sudoeste da Bahia. Laboratório de Produtos Naturais. Jequié, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Federal de Minas Gerais. Laboratório de Biologia Celular e Parasitos Intracelulares. Belo Horizonte, MG, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.The Trichoderma genus comprises several species of fungi whose diversity of secondary metabolites represents a source of potential molecules with medical application. Because of increased pathogen resistance and demand for lower production costs, the search for new pharmacologically active molecules effective against pathogens has become more intense. This is particularly evident in the case of American cutaneous leishmaniasis due to the high toxicity of current treatments, parenteral administration, and increasing rate of refractory cases. We have previously shown that a fungus from genus Trichoderma can be used for treating cerebral malaria in mouse models and inhibit biofilm formation. Here, we evaluated the effect of the ethanolic extract of Trichoderma asperelloides (Ext-Ta) and its fractions on promastigotes and amastigotes of Leishmania amazonensis, a major causative agent of cutaneous leishmaniasis in the New World. Ext-Ta displayed leishmanicidal action on L. amazonensis parasites, and its pharmacological activity was associated with the low-molecular-weight fraction (LMWF) of Ext-Ta. Ultrastructural analysis demonstrated morphological alterations in the mitochondria and the flagellar pocket of promastigotes, with increased lipid body and acidocalcisome formation, microtubule disorganization of the cytoplasm, and intense vacuolization of the cytoplasm when amastigotes were present. We suggest the antiparasitic activity of Trichoderma fungi as a promising tool for developing chemotherapeutic leishmanicidal agents.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42531/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarcosAndreV_Santos_etal_IOC_2020.pdfMarcosAndreV_Santos_etal_IOC_2020.pdfapplication/pdf1884649https://www.arca.fiocruz.br/bitstream/icict/42531/2/MarcosAndreV_Santos_etal_IOC_2020.pdffd9260a74b0ff450d67d9d71dfd36755MD52TEXTMarcosAndreV_Santos_etal_IOC_2020.pdf.txtMarcosAndreV_Santos_etal_IOC_2020.pdf.txtExtracted texttext/plain44380https://www.arca.fiocruz.br/bitstream/icict/42531/3/MarcosAndreV_Santos_etal_IOC_2020.pdf.txt1c60f062dbda7519cb37d773802c025aMD53icict/425312020-08-05 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dc.title.pt_BR.fl_str_mv Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
title Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
spellingShingle Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
Lopes, Denielle de Souza
Leishmania amazonensis
Leishmaniose
Quimioterapia
Trichoderma
Leishmanicida
Leishmania amazonensis
Trichoderma
Chemotherapy
Leishmanicidal
Leishmaniasis
Leishmania amazonensis
title_short Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
title_full Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
title_fullStr Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
title_full_unstemmed Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
title_sort Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis
author Lopes, Denielle de Souza
author_facet Lopes, Denielle de Souza
Santos, Uener Ribeiro dos
Anjos, Danielle Oliveira dos
Silva Júnior, Lauro José Caires da
Paula, Vanderlúcia Fonseca de
Santos, Marcos André Vannier
Jardim, Izaltina Silva
Gomes, Thiago Castro
Pirovani, Carlos Priminho
Santos, Jane Lima
author_role author
author2 Santos, Uener Ribeiro dos
Anjos, Danielle Oliveira dos
Silva Júnior, Lauro José Caires da
Paula, Vanderlúcia Fonseca de
Santos, Marcos André Vannier
Jardim, Izaltina Silva
Gomes, Thiago Castro
Pirovani, Carlos Priminho
Santos, Jane Lima
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Denielle de Souza
Santos, Uener Ribeiro dos
Anjos, Danielle Oliveira dos
Silva Júnior, Lauro José Caires da
Paula, Vanderlúcia Fonseca de
Santos, Marcos André Vannier
Jardim, Izaltina Silva
Gomes, Thiago Castro
Pirovani, Carlos Priminho
Santos, Jane Lima
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Leishmaniose
Quimioterapia
Trichoderma
Leishmanicida
Leishmania amazonensis
topic Leishmania amazonensis
Leishmaniose
Quimioterapia
Trichoderma
Leishmanicida
Leishmania amazonensis
Trichoderma
Chemotherapy
Leishmanicidal
Leishmaniasis
Leishmania amazonensis
dc.subject.en.pt_BR.fl_str_mv Trichoderma
Chemotherapy
Leishmanicidal
Leishmaniasis
Leishmania amazonensis
description Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-04T17:43:21Z
dc.date.available.fl_str_mv 2020-08-04T17:43:21Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LOPES, Danielle de Sousa et al. Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis. Front. Cell. Infect. Microbiol, v. 10. Article 306, July 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42531
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.00306
identifier_str_mv LOPES, Danielle de Sousa et al. Ethanolic Extract of the Fungus Trichoderma asperelloides Induces Ultrastructural Effects and Death on Leishmania amazonensis. Front. Cell. Infect. Microbiol, v. 10. Article 306, July 2020.
2235-2988
10.3389/fcimb.2020.00306
url https://www.arca.fiocruz.br/handle/icict/42531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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