Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil

Detalhes bibliográficos
Autor(a) principal: Arantes, Ighor
Data de Publicação: 2022
Outros Autores: Gräf, Tiago, Andrade, Paula, Chaves, Yury Oliveira, Guimarães, Monick Lindenmeyer, Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52062
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Oswaldo Cruz (FIOCRUZ).
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spelling Arantes, IghorGräf, TiagoAndrade, PaulaChaves, Yury OliveiraGuimarães, Monick LindenmeyerBello, Gonzalo2022-04-06T17:39:59Z2022-04-06T17:39:59Z2022ARANTES, Ighor et al. Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil. Front. Microbiol.,1664-302Xhttps://www.arca.fiocruz.br/handle/icict/5206210.3389/fmicb.2022.835443Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Oswaldo Cruz (FIOCRUZ).Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The HIV-1 epidemic in the Amazonas state, as in most of Brazil, is dominated by subtype B. The state, nonetheless, is singular for its significant co-circulation of the variants BCAR, which can mostly be found in the Caribbean region, and BPAN, a clade that emerged in the United States and aggregates almost the totality of subtype B infections world-wide. The Amazonian HIV-1 epidemic provides a unique scenario to compare the epidemic potential of BPAN and BCAR clades spreading in the same population. To reconstruct the spatiotemporal dynamic and demographic history of both subtype B lineages circulating in Amazonas, we analyzed 1,272 HIV-1 pol sequences sampled in that state between 2009 and 2018. Our phylogeographic analyses revealed that while most BCAR infections resulted from a single successful founder event that took place in the Amazonas state around the late 1970s, most BPAN infections resulted from the expansion of multiple clusters seeded in the state since the late 1980s. Our data support the existence of at least four large clusters of the pandemic form in Amazonas, two of them nested in Brazil’s largest known subtype B cluster (BBR–I), and two others resulting from new introductions detected here. The reconstruction of the demographic history of the most prevalent BPAN (n = 4) and BCAR (n = 1) clades identified in Amazonas revealed that all clades displayed a continuous expansion [effective reproductive number (Re) > 1] until most recent times. During the period of co-circulation from the late 1990s onward, the Re of Amazonian BPAN and BCAR clusters behaved quite alike, fluctuating between 2.0 and 3.0. These findings support that the BCAR and BPAN variants circulating in the Brazilian state of Amazonas displayed different evolutionary histories, but similar epidemic trajectories and transmissibility over the last two decades, which is consistent with the notion that both subtype B variants display comparable epidemic potential. Our findings also revealed that despite significant advances in the treatment of HIV infections in the Amazonas state, BCAR and BPAN variants continue to expand and show no signs of the epidemic stabilization observed in other parts of the country.engFrontiers MediaHIV-1BrasilAmazonaEpidemiasHIV-1BrazilAmazonaEpidemicsVIH-1BrasilAmazonaEpidemiasVIH-1 (Virus de l'Immunodéficience Humaine de type 1)BrésilAmazonaÉpidémiesDissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/52062/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALArantes, Ighor - Dissemination Dynamics of HIV-1.pdfArantes, Ighor - Dissemination Dynamics of 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dc.title.pt_BR.fl_str_mv Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
title Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
spellingShingle Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
Arantes, Ighor
HIV-1
Brasil
Amazona
Epidemias
HIV-1
Brazil
Amazona
Epidemics
VIH-1
Brasil
Amazona
Epidemias
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
Brésil
Amazona
Épidémies
title_short Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
title_full Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
title_fullStr Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
title_full_unstemmed Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
title_sort Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil
author Arantes, Ighor
author_facet Arantes, Ighor
Gräf, Tiago
Andrade, Paula
Chaves, Yury Oliveira
Guimarães, Monick Lindenmeyer
Bello, Gonzalo
author_role author
author2 Gräf, Tiago
Andrade, Paula
Chaves, Yury Oliveira
Guimarães, Monick Lindenmeyer
Bello, Gonzalo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arantes, Ighor
Gräf, Tiago
Andrade, Paula
Chaves, Yury Oliveira
Guimarães, Monick Lindenmeyer
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV-1
Brasil
Amazona
Epidemias
topic HIV-1
Brasil
Amazona
Epidemias
HIV-1
Brazil
Amazona
Epidemics
VIH-1
Brasil
Amazona
Epidemias
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
Brésil
Amazona
Épidémies
dc.subject.en.pt_BR.fl_str_mv HIV-1
Brazil
Amazona
Epidemics
dc.subject.es.pt_BR.fl_str_mv VIH-1
Brasil
Amazona
Epidemias
dc.subject.fr.pt_BR.fl_str_mv VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
Brésil
Amazona
Épidémies
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Oswaldo Cruz (FIOCRUZ).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-04-06T17:39:59Z
dc.date.available.fl_str_mv 2022-04-06T17:39:59Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARANTES, Ighor et al. Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil. Front. Microbiol.,
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52062
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2022.835443
identifier_str_mv ARANTES, Ighor et al. Dissemination dynamics of HIV-1 subtype B pandemic and non-pandemic lineages circulating in Amazonas, Brazil. Front. Microbiol.,
1664-302X
10.3389/fmicb.2022.835443
url https://www.arca.fiocruz.br/handle/icict/52062
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52062/1/license.txt
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