Cytotoxic potential of selected medicinal plants in northeast Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16588 |
Resumo: | CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico) and FAPESB (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado da Bahia). |
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Silva, Thiago Barros Correia daCosta, Cinara O D'SousaGalvão, Alexandre Francisco CerqueiraBomfim, Larissa MendesRodrigues, Ana Carolina Borges da CruzMota, Mauricio Carnaúba da SilvaDantas, Alex ASantos, Tiago Rodrigues dosSoares, Milena Botelho PereiraBezerra, Daniel Pereira2016-12-28T12:37:23Z2016-12-28T12:37:23Z2016SILVA, T. B. C. et al. Cytotoxic potential of selected medicinal plants in northeast Brazil. BMC Complementary and Alternative Medicine, v. 16, p. 199, 2016.1472-6882https://www.arca.fiocruz.br/handle/icict/1658810.1186/s12906-016-1166-1CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico) and FAPESB (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado da Bahia).Universidade Federal de Alagoas. Unidade de Ensino de Viçosa, Campus Arapiraca. Viçosa, AL, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Alagoas. Unidade de Ensino de Viçosa, Campus Arapiraca. Viçosa, AL, BrasilUniversidade Federal de Alagoas. Unidade de Ensino de Viçosa, Campus Arapiraca. Viçosa, AL, BrasilUniversidade Federal de Alagoas. Unidade de Ensino de Viçosa, Campus Arapiraca. Viçosa, AL, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Gonçalo Moniz. Instituto Gonçalo Moniz. Salvador, BA, BrasilGreat biodiversity is a highlight of Brazilian flora. In contrast, the therapeutic potentialities of most species used in folk medicine remain unknown. Several of these species are commonly used to treat cancer. In this study, we investigated the cytotoxic activity of 18 plants from 16 families that are found in the northeast region of Brazil. Methods: The following species were studied: Byrsonima sericea DC. (Malpighiaceae), Cupania impressinervia Acev. Rodr. var. (revoluta) Radlk (Sapindaceae), Duranta repens Linn. (Verbenaceae), Helicostylis tomentosa (Poepp. & Endl) Rusby (Moraceae), Himatanthus bracteatus (A.DC.) Woodson (Apocynaceae), Ipomoea purga (Wender.) Hayne (Convolvulaceae), Ixora coccinea Linn. (Rubiaceae), Mabea piriri Aubl. (Euphorbiaceae), Miconia minutiflora (Melastomataceae), Momordica charantia L. (Cucurbitaceae), Ocotea glomerata (Nees) Mez (Lauraceae), Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees) (Lauraceae), Pavonia fruticosa (Mill.) Fawc. & Rendle (Malvaceae), Psychotria capitata Ruiz & Pav. (Rubiaceae), Schefflera morototoni (Aubl.) Maguire, Steyerm. & Frodin (Araliaceae), Solanum paludosum Moric. (Solanaceae), Xylopia frutescens Aubl. (Annonaceae) and Zanthoxylum rhoifolium Lam. (Rutaceae). Their dried leaves, stems, flowers or fruits were submitted to different solvent extractions, resulting in 55 extracts. After incubating for 72 h, the cytotoxicity of each extract was tested against tumor cell lines using the alamar blue assay. Results: The B. sericea, D. repens, H. bracteatus, I. purga, I. coccinea, M. piriri, O. longifolia and P. capitata extracts demonstrated the most potent cytotoxic activity. The chloroform soluble fractions of D. repens flowers and the hexane extract of I. coccinea flowers led to the isolation of quercetin and a mixture of α- and β-amyrin, respectively, and quercetin showed moderate cytotoxic activity. Conclusion: The B. sericea, D. repens, H. bracteatus, I. purga, I. coccinea, M. piriri, O. longifolia and P. capitata plants were identified as having potent cytotoxic effects. Further investigations are required to determine the mechanisms of cytotoxicity exhibited and their in vivo activities. This work reinforces the need to understand the therapeutics potentialities of Brazilian medicinal plants.engBioMed CentralCitotoxicidadeBrasilPlantas medicinaisProdutos naturaisCytotoxicityNortheastern BrazilMedicinal plantsNatural productsCytotoxic potential of selected medicinal plants in northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16588/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva TBC Cytotoxic potential....pdfSilva TBC Cytotoxic potential....pdfapplication/pdf607171https://www.arca.fiocruz.br/bitstream/icict/16588/2/Silva%20TBC%20Cytotoxic%20potential....pdf95b9dd2851f0490957ef329eb1d35c26MD52TEXTSilva TBC Cytotoxic potential....pdf.txtSilva TBC Cytotoxic potential....pdf.txtExtracted texttext/plain39192https://www.arca.fiocruz.br/bitstream/icict/16588/3/Silva%20TBC%20Cytotoxic%20potential....pdf.txte9b43d830afb579611047187cc2df57fMD53icict/165882023-03-15 14:33:57.502oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| title |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| spellingShingle |
Cytotoxic potential of selected medicinal plants in northeast Brazil Silva, Thiago Barros Correia da Citotoxicidade Brasil Plantas medicinais Produtos naturais Cytotoxicity Northeastern Brazil Medicinal plants Natural products |
| title_short |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| title_full |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| title_fullStr |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| title_full_unstemmed |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| title_sort |
Cytotoxic potential of selected medicinal plants in northeast Brazil |
| author |
Silva, Thiago Barros Correia da |
| author_facet |
Silva, Thiago Barros Correia da Costa, Cinara O D'Sousa Galvão, Alexandre Francisco Cerqueira Bomfim, Larissa Mendes Rodrigues, Ana Carolina Borges da Cruz Mota, Mauricio Carnaúba da Silva Dantas, Alex A Santos, Tiago Rodrigues dos Soares, Milena Botelho Pereira Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Costa, Cinara O D'Sousa Galvão, Alexandre Francisco Cerqueira Bomfim, Larissa Mendes Rodrigues, Ana Carolina Borges da Cruz Mota, Mauricio Carnaúba da Silva Dantas, Alex A Santos, Tiago Rodrigues dos Soares, Milena Botelho Pereira Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Thiago Barros Correia da Costa, Cinara O D'Sousa Galvão, Alexandre Francisco Cerqueira Bomfim, Larissa Mendes Rodrigues, Ana Carolina Borges da Cruz Mota, Mauricio Carnaúba da Silva Dantas, Alex A Santos, Tiago Rodrigues dos Soares, Milena Botelho Pereira Bezerra, Daniel Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Citotoxicidade Brasil Plantas medicinais Produtos naturais |
| topic |
Citotoxicidade Brasil Plantas medicinais Produtos naturais Cytotoxicity Northeastern Brazil Medicinal plants Natural products |
| dc.subject.en.pt_BR.fl_str_mv |
Cytotoxicity Northeastern Brazil Medicinal plants Natural products |
| description |
CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico) and FAPESB (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado da Bahia). |
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2016 |
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2016-12-28T12:37:23Z |
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2016-12-28T12:37:23Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVA, T. B. C. et al. Cytotoxic potential of selected medicinal plants in northeast Brazil. BMC Complementary and Alternative Medicine, v. 16, p. 199, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16588 |
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1472-6882 |
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10.1186/s12906-016-1166-1 |
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SILVA, T. B. C. et al. Cytotoxic potential of selected medicinal plants in northeast Brazil. BMC Complementary and Alternative Medicine, v. 16, p. 199, 2016. 1472-6882 10.1186/s12906-016-1166-1 |
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BioMed Central |
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BioMed Central |
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