Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum

Detalhes bibliográficos
Autor(a) principal: Prestes, Elisa Beatriz
Data de Publicação: 2012
Outros Autores: Bayer-Santos, Ethel, Stoco, Patrícia Hermes, Sincero, Thaís Cristine Marques, Wagner, Glauber, Umaki, Adriana, Fragoso, Stenio Perdigão, Bordignon, Juliano, Steindel, Mário, Grisard, Edmundo Carlos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38779
Resumo: Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.
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spelling Prestes, Elisa BeatrizBayer-Santos, EthelStoco, Patrícia HermesSincero, Thaís Cristine MarquesWagner, GlauberUmaki, AdrianaFragoso, Stenio PerdigãoBordignon, JulianoSteindel, MárioGrisard, Edmundo Carlos2019-12-20T17:52:45Z2019-12-20T17:52:45Z2012PRESTES, Elisa Beatriz et al. Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite’s flagellum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 6, p. 713-719, 2012.1678-8060https://www.arca.fiocruz.br/handle/icict/3877910.1590/s0074-02762012000600002porFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosoma rangeliProtein Tyrosine PhosphatasesFlagellaProteínas Tirosina FosfatasasProteínas Tirosina FosfatasesFlagelosTrypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagelluminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.Protein tyrosine phosphatases (PTPs) play an essential role in the regulation of cell differentiation in pathogenic trypanosomatids. In this study, we describe a PTP expressed by the non-pathogenic protozoan Trypanosoma rangeli (TrPTP2). The gene for this PTP is orthologous to the T. brucei TbPTP1 and Trypanosoma cruzi (TcPTP2) genes. Cloning and expression of the TrPTP2 and TcPTP2 proteins allowed anti-PTP2 monoclonal antibodies to be generated in BALB/c mice. When expressed by T. rangeli epimastigotes and trypomastigotes, native TrPTP2 is detected as a ~65 kDa protein associated with the parasite's flagellum. Given that the flagellum is an important structure for cell differentiation in trypanosomatids, the presence of a protein responsible for tyrosine dephosphorylation in the T. rangeli flagellum could represent an interesting mechanism of regulation in this structure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/38779/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL02ok.pdf02ok.pdfapplication/pdf1501397https://www.arca.fiocruz.br/bitstream/icict/38779/2/02ok.pdf32e38d71a6af650ae907759d0807e458MD52TEXT02ok.pdf.txt02ok.pdf.txtExtracted texttext/plain33018https://www.arca.fiocruz.br/bitstream/icict/38779/3/02ok.pdf.txt18aa3a49977459866b1ca616593b2eb7MD53icict/387792020-05-05 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dc.title.pt_BR.fl_str_mv Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
title Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
spellingShingle Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
Prestes, Elisa Beatriz
Trypanosoma rangeli
Protein Tyrosine Phosphatases
Flagella
Proteínas Tirosina Fosfatasas
Proteínas Tirosina Fosfatases
Flagelos
title_short Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
title_full Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
title_fullStr Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
title_full_unstemmed Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
title_sort Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite's flagellum
author Prestes, Elisa Beatriz
author_facet Prestes, Elisa Beatriz
Bayer-Santos, Ethel
Stoco, Patrícia Hermes
Sincero, Thaís Cristine Marques
Wagner, Glauber
Umaki, Adriana
Fragoso, Stenio Perdigão
Bordignon, Juliano
Steindel, Mário
Grisard, Edmundo Carlos
author_role author
author2 Bayer-Santos, Ethel
Stoco, Patrícia Hermes
Sincero, Thaís Cristine Marques
Wagner, Glauber
Umaki, Adriana
Fragoso, Stenio Perdigão
Bordignon, Juliano
Steindel, Mário
Grisard, Edmundo Carlos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Prestes, Elisa Beatriz
Bayer-Santos, Ethel
Stoco, Patrícia Hermes
Sincero, Thaís Cristine Marques
Wagner, Glauber
Umaki, Adriana
Fragoso, Stenio Perdigão
Bordignon, Juliano
Steindel, Mário
Grisard, Edmundo Carlos
dc.subject.other.pt_BR.fl_str_mv Trypanosoma rangeli
topic Trypanosoma rangeli
Protein Tyrosine Phosphatases
Flagella
Proteínas Tirosina Fosfatasas
Proteínas Tirosina Fosfatases
Flagelos
dc.subject.en.pt_BR.fl_str_mv Protein Tyrosine Phosphatases
Flagella
dc.subject.es.pt_BR.fl_str_mv Proteínas Tirosina Fosfatasas
dc.subject.decs.pt_BR.fl_str_mv Proteínas Tirosina Fosfatases
Flagelos
description Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratórios de Protozoologia e de Bioinformática. Florianópolis, SC, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-12-20T17:52:45Z
dc.date.available.fl_str_mv 2019-12-20T17:52:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PRESTES, Elisa Beatriz et al. Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite’s flagellum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 6, p. 713-719, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38779
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762012000600002
identifier_str_mv PRESTES, Elisa Beatriz et al. Trypanosoma rangeli protein tyrosine phosphatase is associated with the parasite’s flagellum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 6, p. 713-719, 2012.
1678-8060
10.1590/s0074-02762012000600002
url https://www.arca.fiocruz.br/handle/icict/38779
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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