Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report

Detalhes bibliográficos
Autor(a) principal: Salomão, Natália
Data de Publicação: 2022
Outros Autores: Araújo, Luciana, Rabelo, Kíssila, Avvad-Portari, Elyzabeth, Souza, Luiz de, Fernandes, Regina, Valle, Nathália, Ferreira, Luiz, Oliveira, Carlos Basílio de, Oliveira, Rodrigo Basílio de, Souza, Thiara de, Nunes, Priscila, Carvalho, Jorge, Santos, Flavia dos, Paes, Marciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54655
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
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spelling Salomão, NatáliaAraújo, LucianaRabelo, KíssilaAvvad-Portari, ElyzabethSouza, Luiz deFernandes, ReginaValle, NatháliaFerreira, LuizOliveira, Carlos Basílio deOliveira, Rodrigo Basílio deSouza, Thiara deNunes, PriscilaCarvalho, JorgeSantos, Flavia dosPaes, Marciano2022-08-16T13:08:07Z2022-08-16T13:08:07Z2022SALOMÃO, Natália et al. Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report. Microorganisms, v. 10, 872, p. 1 - 12, Apr. 2022.2076-2607https://www.arca.fiocruz.br/handle/icict/5465510.3390/ microorganisms10050872engMDPIChikungunyaPlacentaHistopatologiaImuno-histoquímicaMicroscópio eletrônicoChikungunyaPlacentaHistopathologyImmunohistochemistryElectron microscopyPlacental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto da Mulher e da Criança Fernandes Figueira. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil.Hospital Central da Polícia Militar. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Secretaria Estadual de Saúde do Rio de Janeiro. Departamento de Superintendência de Informações Estratégicas de Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Chikungunya virus (CHIKV) is an arthropod-borne virus first isolated in Tanzania, Africa. The virus has spread to Asia as well as South and Central America through infected Aedes mosquitoes. Vertical transmission may also occur, and was first documented during a chikungunya outbreak in La Réunion Island in 2005. Since then, some authors have been discussing the role of the placenta in maternal–fetal CHIKV transmission. CHIKV infection is characterized by fever, headache, rash, and arthralgia. However, atypical manifestations and clinical complications, including neurological, cardiac, renal, ocular, and dermal, may occur in some cases. In this report, we describe the case of a pregnant woman infected by CHIKV during the third trimester of gestation, who presented with severe dermatological manifestations during the epidemic in Rio de Janeiro, Brazil in 2019. CHIKV RNA and antigens were detected in the placental tissue, which presented with histopathological (deciduitis, fibrin deposition, edema, fetal vessel thickening, and chorioamnionitis) and ultrastructural alterations (cytotrophoblast with mitochondrial swelling and dilated cisterns in endoplasmic reticulum, vesicles in syncytiotrophoblasts, and thickening of the basement membrane of the endothelium).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALNataliaSalomao_FlaviaSantos_etal_IOC_2022.pdfNataliaSalomao_FlaviaSantos_etal_IOC_2022.pdfapplication/pdf4519042https://www.arca.fiocruz.br/bitstream/icict/54655/2/NataliaSalomao_FlaviaSantos_etal_IOC_2022.pdf7a7bab12e37f48148f6401116b88f333MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54655/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/546552022-08-16 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dc.title.pt_BR.fl_str_mv Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
title Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
spellingShingle Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
Salomão, Natália
Chikungunya
Placenta
Histopatologia
Imuno-histoquímica
Microscópio eletrônico
Chikungunya
Placenta
Histopathology
Immunohistochemistry
Electron microscopy
title_short Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
title_full Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
title_fullStr Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
title_full_unstemmed Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
title_sort Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report
author Salomão, Natália
author_facet Salomão, Natália
Araújo, Luciana
Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Souza, Luiz de
Fernandes, Regina
Valle, Nathália
Ferreira, Luiz
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Souza, Thiara de
Nunes, Priscila
Carvalho, Jorge
Santos, Flavia dos
Paes, Marciano
author_role author
author2 Araújo, Luciana
Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Souza, Luiz de
Fernandes, Regina
Valle, Nathália
Ferreira, Luiz
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Souza, Thiara de
Nunes, Priscila
Carvalho, Jorge
Santos, Flavia dos
Paes, Marciano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salomão, Natália
Araújo, Luciana
Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Souza, Luiz de
Fernandes, Regina
Valle, Nathália
Ferreira, Luiz
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Souza, Thiara de
Nunes, Priscila
Carvalho, Jorge
Santos, Flavia dos
Paes, Marciano
dc.subject.other.pt_BR.fl_str_mv Chikungunya
Placenta
Histopatologia
Imuno-histoquímica
Microscópio eletrônico
topic Chikungunya
Placenta
Histopatologia
Imuno-histoquímica
Microscópio eletrônico
Chikungunya
Placenta
Histopathology
Immunohistochemistry
Electron microscopy
dc.subject.en.pt_BR.fl_str_mv Chikungunya
Placenta
Histopathology
Immunohistochemistry
Electron microscopy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-16T13:08:07Z
dc.date.available.fl_str_mv 2022-08-16T13:08:07Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALOMÃO, Natália et al. Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report. Microorganisms, v. 10, 872, p. 1 - 12, Apr. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54655
dc.identifier.issn.pt_BR.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/ microorganisms10050872
identifier_str_mv SALOMÃO, Natália et al. Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report. Microorganisms, v. 10, 872, p. 1 - 12, Apr. 2022.
2076-2607
10.3390/ microorganisms10050872
url https://www.arca.fiocruz.br/handle/icict/54655
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54655/2/NataliaSalomao_FlaviaSantos_etal_IOC_2022.pdf
https://www.arca.fiocruz.br/bitstream/icict/54655/1/license.txt
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