AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats
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Publication Date: | 2010 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Pesquisa Veterinária Brasileira (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2010000700015 |
Summary: | The systemic aspect of vascular damage induced by angiotensin II (ANG II) has been poorly explored in the literature. Considering the presence of ANG II and its specific receptor AT1, in several organs, all tissues might be potentially affected by its effects. The aims of this study were: To evaluate the early histological changes in the heart, liver and kidneys, produced by ANG II infusion, to evaluate the protective effect of losartan. Wistar rats were distributed into three groups: control (no treatment), treated with ANG II, and treated with ANG II + losartan. ANG II was continuously infused over 72 hours by subcutaneous osmotic pumps. Histological sections of the myocardium, kidneys and liver were stained and observed for the presence of necrosis. There were ANG II-induced perivascular inflammation and necrosis of the arteriolar wall in the myocardium, kidney, and liver by, which were partially prevented by losartan. There was no significant correlation between heart and kidney damage. Tissue lesion severity was lower than that of vascular lesions, without statistical difference between groups. ANG II causes vascular injury in the heart, kidneys and liver, indicating a systemic vasculotoxic effect; the mechanisms of damage/protection vary depending on the target organ; perivascular lesions may occur even when anti-hypertensive doses of losartan are used. |
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AT1-receptor mediated vascular damage in myocardium, kidneys and liver in ratsAngiotensinarterieshypertensionremodelingnecrosisThe systemic aspect of vascular damage induced by angiotensin II (ANG II) has been poorly explored in the literature. Considering the presence of ANG II and its specific receptor AT1, in several organs, all tissues might be potentially affected by its effects. The aims of this study were: To evaluate the early histological changes in the heart, liver and kidneys, produced by ANG II infusion, to evaluate the protective effect of losartan. Wistar rats were distributed into three groups: control (no treatment), treated with ANG II, and treated with ANG II + losartan. ANG II was continuously infused over 72 hours by subcutaneous osmotic pumps. Histological sections of the myocardium, kidneys and liver were stained and observed for the presence of necrosis. There were ANG II-induced perivascular inflammation and necrosis of the arteriolar wall in the myocardium, kidney, and liver by, which were partially prevented by losartan. There was no significant correlation between heart and kidney damage. Tissue lesion severity was lower than that of vascular lesions, without statistical difference between groups. ANG II causes vascular injury in the heart, kidneys and liver, indicating a systemic vasculotoxic effect; the mechanisms of damage/protection vary depending on the target organ; perivascular lesions may occur even when anti-hypertensive doses of losartan are used.Colégio Brasileiro de Patologia Animal - CBPA2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2010000700015Pesquisa Veterinária Brasileira v.30 n.7 2010reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2010000700015info:eu-repo/semantics/openAccessVailati,Maria do Carmo FernandezRocha,Noeme SouzaMatsubara,Luiz ShigueroPadovani,Carlos RobertoSchwartz,Denise SarettaMatsubara,Beatriz Bojikianeng2010-08-30T00:00:00Zoai:scielo:S0100-736X2010000700015Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2010-08-30T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
title |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
spellingShingle |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats Vailati,Maria do Carmo Fernandez Angiotensin arteries hypertension remodeling necrosis |
title_short |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
title_full |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
title_fullStr |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
title_full_unstemmed |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
title_sort |
AT1-receptor mediated vascular damage in myocardium, kidneys and liver in rats |
author |
Vailati,Maria do Carmo Fernandez |
author_facet |
Vailati,Maria do Carmo Fernandez Rocha,Noeme Souza Matsubara,Luiz Shiguero Padovani,Carlos Roberto Schwartz,Denise Saretta Matsubara,Beatriz Bojikian |
author_role |
author |
author2 |
Rocha,Noeme Souza Matsubara,Luiz Shiguero Padovani,Carlos Roberto Schwartz,Denise Saretta Matsubara,Beatriz Bojikian |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vailati,Maria do Carmo Fernandez Rocha,Noeme Souza Matsubara,Luiz Shiguero Padovani,Carlos Roberto Schwartz,Denise Saretta Matsubara,Beatriz Bojikian |
dc.subject.por.fl_str_mv |
Angiotensin arteries hypertension remodeling necrosis |
topic |
Angiotensin arteries hypertension remodeling necrosis |
description |
The systemic aspect of vascular damage induced by angiotensin II (ANG II) has been poorly explored in the literature. Considering the presence of ANG II and its specific receptor AT1, in several organs, all tissues might be potentially affected by its effects. The aims of this study were: To evaluate the early histological changes in the heart, liver and kidneys, produced by ANG II infusion, to evaluate the protective effect of losartan. Wistar rats were distributed into three groups: control (no treatment), treated with ANG II, and treated with ANG II + losartan. ANG II was continuously infused over 72 hours by subcutaneous osmotic pumps. Histological sections of the myocardium, kidneys and liver were stained and observed for the presence of necrosis. There were ANG II-induced perivascular inflammation and necrosis of the arteriolar wall in the myocardium, kidney, and liver by, which were partially prevented by losartan. There was no significant correlation between heart and kidney damage. Tissue lesion severity was lower than that of vascular lesions, without statistical difference between groups. ANG II causes vascular injury in the heart, kidneys and liver, indicating a systemic vasculotoxic effect; the mechanisms of damage/protection vary depending on the target organ; perivascular lesions may occur even when anti-hypertensive doses of losartan are used. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2010000700015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2010000700015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2010000700015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.30 n.7 2010 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122230428598272 |