The maspin expression in canine mammary tumors: an immunohistochemical and molecular study
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000200015 |
Resumo: | The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia. |
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The maspin expression in canine mammary tumors: an immunohistochemical and molecular studyMaspincanine mammary tumorimmunohistochemistrymolecular biologyprognosisThe serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia.Colégio Brasileiro de Patologia Animal - CBPA2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000200015Pesquisa Veterinária Brasileira v.29 n.2 2009reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2009000200015info:eu-repo/semantics/openAccessZuccari,Debora A.P.C.Castro,RodrigoGavioli,Arieli F.Mancini,Ulises M.Tajara,Eloisa H.Frade,Cibelli S.Pivaro,Luana R.Carmona-Raphe,JulianaTerzian,Ana Carolina B.Ruiz,Camila M.Bertollo,Eny M. GoloniPavarino-Bertelli,Érika C.eng2009-03-10T00:00:00Zoai:scielo:S0100-736X2009000200015Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2009-03-10T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
title |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
spellingShingle |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study Zuccari,Debora A.P.C. Maspin canine mammary tumor immunohistochemistry molecular biology prognosis |
title_short |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
title_full |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
title_fullStr |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
title_full_unstemmed |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
title_sort |
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study |
author |
Zuccari,Debora A.P.C. |
author_facet |
Zuccari,Debora A.P.C. Castro,Rodrigo Gavioli,Arieli F. Mancini,Ulises M. Tajara,Eloisa H. Frade,Cibelli S. Pivaro,Luana R. Carmona-Raphe,Juliana Terzian,Ana Carolina B. Ruiz,Camila M. Bertollo,Eny M. Goloni Pavarino-Bertelli,Érika C. |
author_role |
author |
author2 |
Castro,Rodrigo Gavioli,Arieli F. Mancini,Ulises M. Tajara,Eloisa H. Frade,Cibelli S. Pivaro,Luana R. Carmona-Raphe,Juliana Terzian,Ana Carolina B. Ruiz,Camila M. Bertollo,Eny M. Goloni Pavarino-Bertelli,Érika C. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zuccari,Debora A.P.C. Castro,Rodrigo Gavioli,Arieli F. Mancini,Ulises M. Tajara,Eloisa H. Frade,Cibelli S. Pivaro,Luana R. Carmona-Raphe,Juliana Terzian,Ana Carolina B. Ruiz,Camila M. Bertollo,Eny M. Goloni Pavarino-Bertelli,Érika C. |
dc.subject.por.fl_str_mv |
Maspin canine mammary tumor immunohistochemistry molecular biology prognosis |
topic |
Maspin canine mammary tumor immunohistochemistry molecular biology prognosis |
description |
The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2009000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2009000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.29 n.2 2009 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122229471248384 |