Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001000798 |
Resumo: | ABSTRACT: In forensic toxicology, the detection of toxic chemicals from human bone marrow is often used in cases with an extended post mortem interval; however, in veterinary medicine, this practice is not used. Therefore, this study was performed to investigate the suitability of bone marrow for toxicological analysis in dogs and cats. Six animals with suspected poisoning were selected; the carcasses were sent for necropsy, and the organs were collected and preserved in buffered formalin and processed routinely for histological examination. In addition, bone marrow samples from the femur, humerus, and tibia were collected for toxicological analysis by liquid chromatography coupled to mass spectrometry detection (LC-MS). This analysis confirmed the presence of aldicarb, aldicarb sulfone, asulam, carbendazim, chlorpyrifos, dichlorvos, thifensulfuron methyl and trifloxysulfuron-sodium and associated with clinical symptoms and anatomo-histopathological alterations it was recognized the poisonings. It is expected that this study will promote the toxicological investigation of bone marrow and open avenues for the use of this tissue as an option for the detection of toxic chemicals in cases of forensic pathology. |
id |
EMBRAPA-2_ba6b45f0f8abea70ca2e322fcc807c60 |
---|---|
oai_identifier_str |
oai:scielo:S0100-736X2020001000798 |
network_acronym_str |
EMBRAPA-2 |
network_name_str |
Pesquisa Veterinária Brasileira (Online) |
repository_id_str |
|
spelling |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicineBone marrowtoxic chemicalspoisoningforensic toxicologyaldicarbdichlorvoschlorpyrifospesticidesherbicidescrimesABSTRACT: In forensic toxicology, the detection of toxic chemicals from human bone marrow is often used in cases with an extended post mortem interval; however, in veterinary medicine, this practice is not used. Therefore, this study was performed to investigate the suitability of bone marrow for toxicological analysis in dogs and cats. Six animals with suspected poisoning were selected; the carcasses were sent for necropsy, and the organs were collected and preserved in buffered formalin and processed routinely for histological examination. In addition, bone marrow samples from the femur, humerus, and tibia were collected for toxicological analysis by liquid chromatography coupled to mass spectrometry detection (LC-MS). This analysis confirmed the presence of aldicarb, aldicarb sulfone, asulam, carbendazim, chlorpyrifos, dichlorvos, thifensulfuron methyl and trifloxysulfuron-sodium and associated with clinical symptoms and anatomo-histopathological alterations it was recognized the poisonings. It is expected that this study will promote the toxicological investigation of bone marrow and open avenues for the use of this tissue as an option for the detection of toxic chemicals in cases of forensic pathology.Colégio Brasileiro de Patologia Animal - CBPA2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001000798Pesquisa Veterinária Brasileira v.40 n.10 2020reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-6709info:eu-repo/semantics/openAccessMarcelino,Sóstenes A.C.Serakides,RogériaCastro-Silva,Viviane N.Ramos,Maria L.Ocarino,Natália M.Melo,Marília M.eng2020-12-10T00:00:00Zoai:scielo:S0100-736X2020001000798Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2020-12-10T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
title |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
spellingShingle |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine Marcelino,Sóstenes A.C. Bone marrow toxic chemicals poisoning forensic toxicology aldicarb dichlorvos chlorpyrifos pesticides herbicides crimes |
title_short |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
title_full |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
title_fullStr |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
title_full_unstemmed |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
title_sort |
Use of bone marrow for detection of toxic chemicals for the elucidation of poisoning in forensic veterinary medicine |
author |
Marcelino,Sóstenes A.C. |
author_facet |
Marcelino,Sóstenes A.C. Serakides,Rogéria Castro-Silva,Viviane N. Ramos,Maria L. Ocarino,Natália M. Melo,Marília M. |
author_role |
author |
author2 |
Serakides,Rogéria Castro-Silva,Viviane N. Ramos,Maria L. Ocarino,Natália M. Melo,Marília M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Marcelino,Sóstenes A.C. Serakides,Rogéria Castro-Silva,Viviane N. Ramos,Maria L. Ocarino,Natália M. Melo,Marília M. |
dc.subject.por.fl_str_mv |
Bone marrow toxic chemicals poisoning forensic toxicology aldicarb dichlorvos chlorpyrifos pesticides herbicides crimes |
topic |
Bone marrow toxic chemicals poisoning forensic toxicology aldicarb dichlorvos chlorpyrifos pesticides herbicides crimes |
description |
ABSTRACT: In forensic toxicology, the detection of toxic chemicals from human bone marrow is often used in cases with an extended post mortem interval; however, in veterinary medicine, this practice is not used. Therefore, this study was performed to investigate the suitability of bone marrow for toxicological analysis in dogs and cats. Six animals with suspected poisoning were selected; the carcasses were sent for necropsy, and the organs were collected and preserved in buffered formalin and processed routinely for histological examination. In addition, bone marrow samples from the femur, humerus, and tibia were collected for toxicological analysis by liquid chromatography coupled to mass spectrometry detection (LC-MS). This analysis confirmed the presence of aldicarb, aldicarb sulfone, asulam, carbendazim, chlorpyrifos, dichlorvos, thifensulfuron methyl and trifloxysulfuron-sodium and associated with clinical symptoms and anatomo-histopathological alterations it was recognized the poisonings. It is expected that this study will promote the toxicological investigation of bone marrow and open avenues for the use of this tissue as an option for the detection of toxic chemicals in cases of forensic pathology. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001000798 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001000798 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-5150-pvb-6709 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.40 n.10 2020 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122240473956352 |