Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1065162 http://dx.doi.org/10.1136/vr.103546 |
Resumo: | Porcine periweaning-failure-to-thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome-wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease. |
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Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs.DepressionGWASPFTSGenômicaDesmameLeitãoGenomaPigletsWeaningPorcine periweaning-failure-to-thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome-wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease.RICARDO ZANELLA, UFP; NELSON MORES, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; UPF; JANICE REIS CIACCI ZANELLA, CNPSA; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; DANIELLE GAVA, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA.ZANELLA, R.MORES, N.MORES, M. A. Z.PEIXOTO, J. de O.ZANELLA, E. L.ZANELLA, J. R. C.IBELLI, A. M. G.GAVA, D.CANTAO, M. E.LEDUR, M. C.2023-03-03T12:57:19Z2023-03-03T12:57:19Z2017-02-222016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVeterinary Record, v. 178, n. 26, p. 1-7, 2016.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1065162http://dx.doi.org/10.1136/vr.103546enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2023-03-03T12:57:19Zoai:www.alice.cnptia.embrapa.br:doc/1065162Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542023-03-03T12:57:19falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542023-03-03T12:57:19Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
title |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
spellingShingle |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. ZANELLA, R. Depression GWAS PFTS Genômica Desmame Leitão Genoma Piglets Weaning |
title_short |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
title_full |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
title_fullStr |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
title_full_unstemmed |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
title_sort |
Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. |
author |
ZANELLA, R. |
author_facet |
ZANELLA, R. MORES, N. MORES, M. A. Z. PEIXOTO, J. de O. ZANELLA, E. L. ZANELLA, J. R. C. IBELLI, A. M. G. GAVA, D. CANTAO, M. E. LEDUR, M. C. |
author_role |
author |
author2 |
MORES, N. MORES, M. A. Z. PEIXOTO, J. de O. ZANELLA, E. L. ZANELLA, J. R. C. IBELLI, A. M. G. GAVA, D. CANTAO, M. E. LEDUR, M. C. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
RICARDO ZANELLA, UFP; NELSON MORES, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; UPF; JANICE REIS CIACCI ZANELLA, CNPSA; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; DANIELLE GAVA, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA. |
dc.contributor.author.fl_str_mv |
ZANELLA, R. MORES, N. MORES, M. A. Z. PEIXOTO, J. de O. ZANELLA, E. L. ZANELLA, J. R. C. IBELLI, A. M. G. GAVA, D. CANTAO, M. E. LEDUR, M. C. |
dc.subject.por.fl_str_mv |
Depression GWAS PFTS Genômica Desmame Leitão Genoma Piglets Weaning |
topic |
Depression GWAS PFTS Genômica Desmame Leitão Genoma Piglets Weaning |
description |
Porcine periweaning-failure-to-thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome-wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2017-02-22 2023-03-03T12:57:19Z 2023-03-03T12:57:19Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Veterinary Record, v. 178, n. 26, p. 1-7, 2016. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1065162 http://dx.doi.org/10.1136/vr.103546 |
identifier_str_mv |
Veterinary Record, v. 178, n. 26, p. 1-7, 2016. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1065162 http://dx.doi.org/10.1136/vr.103546 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
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EMBRAPA |
institution |
EMBRAPA |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503541018066944 |