Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.

Detalhes bibliográficos
Autor(a) principal: BIGI, M. M.
Data de Publicação: 2016
Outros Autores: BLANCO, F. C., ARAUJO, F. R., THACKER, T. C., ZUMÁRRAGA, M. J., CATALDI, A. A., SORIA, M. A., BIGI, F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1087980
Resumo: Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
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spelling Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.RegulatorPolimorfismoAnoxiaMycobacterium BovisMycobacterium tuberculosisPolymorphismMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.María M. Bigi, School of Agronomy - UBA; Federico Carlos Blanco, Biotechnology Institute/National Institute of Agricultural Technology - INTA; FLABIO RIBEIRO ARAUJO, CNPGC; Tyler C. Thacker, United States Department of Agriculture/Agricultural Research Service/National Animal Disease Center; Martín J. Zumárraga, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Angel A. Cataldi, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Marcelo A. Soria, School of Agronomy - UBA; Fabiana Bigi, Biotechnology Institute/National Institute of Agricultural Technology - INTA.BIGI, M. M.BLANCO, F. C.ARAUJO, F. R.THACKER, T. C.ZUMÁRRAGA, M. J.CATALDI, A. A.SORIA, M. A.BIGI, F.2018-02-22T00:40:07Z2018-02-22T00:40:07Z2018-02-2120162018-02-22T00:40:07Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMicrobiology and Immunology, v. 60, n. 8, p. 552-560, August 2016http://www.alice.cnptia.embrapa.br/alice/handle/doc/1087980enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2018-02-22T00:40:14Zoai:www.alice.cnptia.embrapa.br:doc/1087980Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542018-02-22T00:40:14falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542018-02-22T00:40:14Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
title Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
spellingShingle Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
BIGI, M. M.
Regulator
Polimorfismo
Anoxia
Mycobacterium Bovis
Mycobacterium tuberculosis
Polymorphism
title_short Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
title_full Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
title_fullStr Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
title_full_unstemmed Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
title_sort Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
author BIGI, M. M.
author_facet BIGI, M. M.
BLANCO, F. C.
ARAUJO, F. R.
THACKER, T. C.
ZUMÁRRAGA, M. J.
CATALDI, A. A.
SORIA, M. A.
BIGI, F.
author_role author
author2 BLANCO, F. C.
ARAUJO, F. R.
THACKER, T. C.
ZUMÁRRAGA, M. J.
CATALDI, A. A.
SORIA, M. A.
BIGI, F.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv María M. Bigi, School of Agronomy - UBA; Federico Carlos Blanco, Biotechnology Institute/National Institute of Agricultural Technology - INTA; FLABIO RIBEIRO ARAUJO, CNPGC; Tyler C. Thacker, United States Department of Agriculture/Agricultural Research Service/National Animal Disease Center; Martín J. Zumárraga, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Angel A. Cataldi, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Marcelo A. Soria, School of Agronomy - UBA; Fabiana Bigi, Biotechnology Institute/National Institute of Agricultural Technology - INTA.
dc.contributor.author.fl_str_mv BIGI, M. M.
BLANCO, F. C.
ARAUJO, F. R.
THACKER, T. C.
ZUMÁRRAGA, M. J.
CATALDI, A. A.
SORIA, M. A.
BIGI, F.
dc.subject.por.fl_str_mv Regulator
Polimorfismo
Anoxia
Mycobacterium Bovis
Mycobacterium tuberculosis
Polymorphism
topic Regulator
Polimorfismo
Anoxia
Mycobacterium Bovis
Mycobacterium tuberculosis
Polymorphism
description Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018-02-22T00:40:07Z
2018-02-22T00:40:07Z
2018-02-21
2018-02-22T00:40:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1087980
identifier_str_mv Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1087980
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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