Complete mole in a dichorionic twin pregnancy after intracytoplasmic sperm injection

• Autor(a) principal: Ferraz,Tiago José Santos de Matos
• Data de Publicação: 2013
• Outros Autores: Bartosch,Carla Maria Magno, Ramalho,Carla Maria Almeida, Carvalho,Filipa Abreu Gomes de, Carvalho,Berta Cecília Campos Lima de, Brandão,Otília Gonçalves Bento Cavaleiro, Montenegro,Nuno Aires Mota Mendonça
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista brasileira de ginecologia e obstetrícia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032013000100008
• topic: Hydatidiform mole; Sperm injections, intracytoplasmic; Pregnancy, twin; Case reports

A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform mole, leading to pregnancy termination. Autopsy and histological examinations diagnosed a complete mole coexisting with a normal fetus, and the genetic analysis showed a diploid fetus with biparental genome and molar tissue with paternal diploidy. This case highlighted that complete molar pregnancies may still occur even though pregnancy is achieved after intracytoplasmic sperm injection. A review of the literature was performed by collecting data from the few similar reported cases and by commenting on the pathogenesis of this rare condition.