Production and evaluation of tablets containing high amount of Maytenus ilicifolia dried extract

• Main Author: Soares, Luiz Alberto Lira
• Publication Date: 2020
• Other Authors: Assunção Ferreira, Magda Rhayanne
• Format: Article
• Language: por
• Source: Revista Fitos
• Download full: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/881
• topic: Maytenus ilicifolia; Espinheira-santa; Dried extract; Tablets; Formulation; Phytopharmaceutical; Maytenus ilicifolia; Espinheira-santa; Comprimidos; Fitoterápicos; Extrato seco; Formulação

The aim of this work was the evaluation of influence from excipients on the properties of tablets containing high-dose of granules from spray-dried product of Maytenus ilicifolia leaves. Thus several excipients were studied such as filler/binder (microcrystalline cellulose; microcrystalline cellulose co-processed with α-lactose monohydrated; α-lactose monohydrated co-processed with polyvinylpyrrolidone and cross-linked polyvinylpyrrolidone; or, calcium phosphate); superdisintegrants (sodium starch glycolate, sodium cellulose glycolate or cross-linked polyvinylpyrrolidone); and, lubricants/glidants (colloidal silicon dioxide and magnesium stearate). The crushing strength and disintegration times of tablets were preliminarily evaluated, and the results showed that formulation containing microcrystalline cellulose and sodium cellulose glycolate produced tablets with appropriate crushing strength and disintegration time. The final tablets prepared by the selected excipients, showed crushing strength of 88.0 ± 5.2 N, absence of friability or weight variation, maximum disintegration time of 13.2 minutes and total dissolution at 25 minutes. The total tannin content evaluated by spectrophotometric assay, showed that the chemical constituents were stable during the technological transformations of the extractive solutions.