Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Monzote Fidalgo,Lianet
Data de Publicação: 2004
Outros Autores: Montalvo Álvarez,Ana Margarita, Geigel,Lisset Fonseca, Pérez Pineiro,Rolando, Suárez Navarro,Margarita, Rodríguez Cabrera,Hortensia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300016
Resumo: Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
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spelling Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensisLeishmaniathiadiazineamastigotesCurrent therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.Instituto Oswaldo Cruz, Ministério da Saúde2004-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300016Memórias do Instituto Oswaldo Cruz v.99 n.3 2004reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762004000300016info:eu-repo/semantics/openAccessMonzote Fidalgo,LianetMontalvo Álvarez,Ana MargaritaGeigel,Lisset FonsecaPérez Pineiro,RolandoSuárez Navarro,MargaritaRodríguez Cabrera,Hortensiaeng2020-04-25T17:49:15Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:12:36.492Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
title Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
spellingShingle Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
Monzote Fidalgo,Lianet
Leishmania
thiadiazine
amastigotes
title_short Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
title_full Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
title_fullStr Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
title_full_unstemmed Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
title_sort Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis
author Monzote Fidalgo,Lianet
author_facet Monzote Fidalgo,Lianet
Montalvo Álvarez,Ana Margarita
Geigel,Lisset Fonseca
Pérez Pineiro,Rolando
Suárez Navarro,Margarita
Rodríguez Cabrera,Hortensia
author_role author
author2 Montalvo Álvarez,Ana Margarita
Geigel,Lisset Fonseca
Pérez Pineiro,Rolando
Suárez Navarro,Margarita
Rodríguez Cabrera,Hortensia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Monzote Fidalgo,Lianet
Montalvo Álvarez,Ana Margarita
Geigel,Lisset Fonseca
Pérez Pineiro,Rolando
Suárez Navarro,Margarita
Rodríguez Cabrera,Hortensia
dc.subject.por.fl_str_mv Leishmania
thiadiazine
amastigotes
topic Leishmania
thiadiazine
amastigotes
dc.description.none.fl_txt_mv Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
description Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
publishDate 2004
dc.date.none.fl_str_mv 2004-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300016
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762004000300016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.99 n.3 2004
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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