Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira,Gisele R de
Data de Publicação: 2017
Outros Autores: Siqueira,Juliana D, Finger-Jardim,Fabiana, Vieira,Valdimara C, Silva,Ronald L, Gonçalves,Carla V, Soares,Esmeralda A, Martinez,Ana Maria Barral de, Soares,Marcelo A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001000728
Resumo: The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.
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spelling Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazilhuman papillomaviruslineagecomplete genomesouthern BrazilThe classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.Instituto Oswaldo Cruz, Ministério da Saúde2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001000728Memórias do Instituto Oswaldo Cruz v.112 n.10 2017reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760170121info:eu-repo/semantics/openAccessOliveira,Gisele R deSiqueira,Juliana DFinger-Jardim,FabianaVieira,Valdimara CSilva,Ronald LGonçalves,Carla VSoares,Esmeralda AMartinez,Ana Maria Barral deSoares,Marcelo Aeng2020-04-25T17:52:39Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:21:52.359Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
title Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
spellingShingle Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
Oliveira,Gisele R de
human papillomavirus
lineage
complete genome
southern Brazil
title_short Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
title_full Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
title_fullStr Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
title_full_unstemmed Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
title_sort Characterisation of complete high- and low-risk human papillomavirus genomes isolated from cervical specimens in southern Brazil
author Oliveira,Gisele R de
author_facet Oliveira,Gisele R de
Siqueira,Juliana D
Finger-Jardim,Fabiana
Vieira,Valdimara C
Silva,Ronald L
Gonçalves,Carla V
Soares,Esmeralda A
Martinez,Ana Maria Barral de
Soares,Marcelo A
author_role author
author2 Siqueira,Juliana D
Finger-Jardim,Fabiana
Vieira,Valdimara C
Silva,Ronald L
Gonçalves,Carla V
Soares,Esmeralda A
Martinez,Ana Maria Barral de
Soares,Marcelo A
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Gisele R de
Siqueira,Juliana D
Finger-Jardim,Fabiana
Vieira,Valdimara C
Silva,Ronald L
Gonçalves,Carla V
Soares,Esmeralda A
Martinez,Ana Maria Barral de
Soares,Marcelo A
dc.subject.por.fl_str_mv human papillomavirus
lineage
complete genome
southern Brazil
topic human papillomavirus
lineage
complete genome
southern Brazil
dc.description.none.fl_txt_mv The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.
description The classification of human papillomavirus (HPV) intratypic lineages by complete genome sequencing is a determinant in understanding biological differences in association with this disease. In this work, we have characterised complete HPV genomes from southern Brazil. Fifteen cervicovaginal Pap smear negative samples previously categorised as HPV-positive were sequenced using ultradeep sequencing, and 18 complete genomes from 13 different HPV types were assembled. Phylogenetic and genetic distance analyses were performed to classify the HPV genomes into lineages and sublineages. This is the first report describing the distribution of HPV intratype lineages of high and low oncogenic risk in asymptomatic women from southern Brazil.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001000728
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001000728
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-02760170121
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.112 n.10 2017
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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