Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis

Detalhes bibliográficos
Autor(a) principal: Horstmann,Rolf D.
Data de Publicação: 1992
Outros Autores: Leippe,Mathias, Tannich,Egbert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007
Resumo: Entamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms.
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spelling Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysistaxonomyparasite pathogenicityamoebiasisEntamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007Memórias do Instituto Oswaldo Cruz v.87 suppl.5 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000900007info:eu-repo/semantics/openAccessHorstmann,Rolf D.Leippe,MathiasTannich,Egberteng2020-04-25T17:47:04Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:26.805Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
title Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
spellingShingle Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
Horstmann,Rolf D.
taxonomy
parasite pathogenicity
amoebiasis
title_short Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
title_full Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
title_fullStr Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
title_full_unstemmed Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
title_sort Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
author Horstmann,Rolf D.
author_facet Horstmann,Rolf D.
Leippe,Mathias
Tannich,Egbert
author_role author
author2 Leippe,Mathias
Tannich,Egbert
author2_role author
author
dc.contributor.author.fl_str_mv Horstmann,Rolf D.
Leippe,Mathias
Tannich,Egbert
dc.subject.por.fl_str_mv taxonomy
parasite pathogenicity
amoebiasis
topic taxonomy
parasite pathogenicity
amoebiasis
dc.description.none.fl_txt_mv Entamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms.
description Entamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms.
publishDate 1992
dc.date.none.fl_str_mv 1992-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000900007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 suppl.5 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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