A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence

Detalhes bibliográficos
Autor(a) principal: Kemp,D. J.
Data de Publicação: 1992
Outros Autores: Thompson,J., Barnes,D. A., Triglia,T., Karamalis,F., Petersen,C., Brown,G. V., Day,K. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700011
Resumo: Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.
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spelling A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherencechromosome deletioncytoadherencePlasmodium falciparumpathologyPfEMP1Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700011Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000700011info:eu-repo/semantics/openAccessKemp,D. J.Thompson,J.Barnes,D. A.Triglia,T.Karamalis,F.Petersen,C.Brown,G. V.Day,K. P.eng2020-04-25T17:46:56Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:02.069Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
title A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
spellingShingle A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
Kemp,D. J.
chromosome deletion
cytoadherence
Plasmodium falciparum
pathology
PfEMP1
title_short A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
title_full A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
title_fullStr A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
title_full_unstemmed A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
title_sort A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
author Kemp,D. J.
author_facet Kemp,D. J.
Thompson,J.
Barnes,D. A.
Triglia,T.
Karamalis,F.
Petersen,C.
Brown,G. V.
Day,K. P.
author_role author
author2 Thompson,J.
Barnes,D. A.
Triglia,T.
Karamalis,F.
Petersen,C.
Brown,G. V.
Day,K. P.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kemp,D. J.
Thompson,J.
Barnes,D. A.
Triglia,T.
Karamalis,F.
Petersen,C.
Brown,G. V.
Day,K. P.
dc.subject.por.fl_str_mv chromosome deletion
cytoadherence
Plasmodium falciparum
pathology
PfEMP1
topic chromosome deletion
cytoadherence
Plasmodium falciparum
pathology
PfEMP1
dc.description.none.fl_txt_mv Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.
description Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.
publishDate 1992
dc.date.none.fl_str_mv 1992-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700011
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000700011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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