Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781 |
Resumo: | The aim of this study was to describe the effect of non-adherence on the main laboratory outcomes, TCD4+ lymphocyte count and viral load, routinely used to monitor patients initiating treatment according to three different approaches to measure adherence to antiretroviral therapy. Among 288 participants, 22.9%, 31.9% and 74.3% were considered non-adherent, according to medical charts, self-report and pharmacy records, respectively. Depending on the adherence measures used, the average gain in TCD4+ lymphocyte count ranged from 142.4 to 195.4 cells/mm3 among adherent patients, and from 58.5 to 99.8 lymphocytes TCD4+/mm3 among those non-adherent. The average reduction on viral load ranged from 4.25 to 4.62 log copies/mL among the adherent patients, and from 1.99 to 4.07 log among those non-adherent. Monitoring antiretroviral adherence should be considered a priority in these public AIDS referral centers in order to identify patients at high risk of developing virologic failure. Early interventions are necessary in order to maintain the initial therapeutic regimens for longer periods. |
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Monitoring adherence to antiretroviral treatment in Brazil: an urgent challengeAnti-Retroviral AgentsAcquired Immunodeficiency SyndromeViral LoadCD4 Lymphocyte CountMedication AdherenceThe aim of this study was to describe the effect of non-adherence on the main laboratory outcomes, TCD4+ lymphocyte count and viral load, routinely used to monitor patients initiating treatment according to three different approaches to measure adherence to antiretroviral therapy. Among 288 participants, 22.9%, 31.9% and 74.3% were considered non-adherent, according to medical charts, self-report and pharmacy records, respectively. Depending on the adherence measures used, the average gain in TCD4+ lymphocyte count ranged from 142.4 to 195.4 cells/mm3 among adherent patients, and from 58.5 to 99.8 lymphocytes TCD4+/mm3 among those non-adherent. The average reduction on viral load ranged from 4.25 to 4.62 log copies/mL among the adherent patients, and from 1.99 to 4.07 log among those non-adherent. Monitoring antiretroviral adherence should be considered a priority in these public AIDS referral centers in order to identify patients at high risk of developing virologic failure. Early interventions are necessary in order to maintain the initial therapeutic regimens for longer periods.O objetivo deste estudo foi descrever o efeito da não-adesão nos principais desfechos laboratoriais, contagem de linfócitos TCD4+ e carga viral, rotineiramente utilizados para monitoramento de pacientes iniciando tratamento segundo três diferentes formas de medir adesão à terapia antirretroviral. Entre 288 participantes, 22,9%, 31,9% e 74,3% foram considerados não-aderentes, respectivamente, pelos registros em prontuários médicos, autorrelato e registros de dispensação nas farmácias. Dependendo da medida de adesão utilizada, o ganho médio de linfócitos TCD4+ variou de 142,4 a 195,4 células/mm³ para participantes aderentes, comparados com 58,5 a 99,8 para não-aderentes. A redução média na carga viral variou de 4,25 a 4,62 log cópias/mL entre aderentes, comparados com 1,99 a 4,07 para não-aderentes. O monitoramento da adesão à terapia antirretroviral deve ser uma prioridade nos serviços de referência de AIDS, sendo capaz de identificar pacientes com alto risco de desenvolver falência virológica e permitindo intervenções precoces com possibilidade de preservação de esquemas terapêuticos iniciais.Reports in Public HealthCadernos de Saúde Pública2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781Reports in Public Health; Vol. 27 No. 13 (2011): Supplement 1Cadernos de Saúde Pública; v. 27 n. 13 (2011): Suplemento 11678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781/9759https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781/9760Rocha, Gustavo MachadoMachado, Carla JorgeAcurcio, Francisco de AssisGuimarães, Mark Drew Croslandinfo:eu-repo/semantics/openAccess2024-03-06T15:28:21Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/4781Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:05:30.973859Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
title |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
spellingShingle |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge Rocha, Gustavo Machado Anti-Retroviral Agents Acquired Immunodeficiency Syndrome Viral Load CD4 Lymphocyte Count Medication Adherence |
title_short |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
title_full |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
title_fullStr |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
title_full_unstemmed |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
title_sort |
Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge |
author |
Rocha, Gustavo Machado |
author_facet |
Rocha, Gustavo Machado Machado, Carla Jorge Acurcio, Francisco de Assis Guimarães, Mark Drew Crosland |
author_role |
author |
author2 |
Machado, Carla Jorge Acurcio, Francisco de Assis Guimarães, Mark Drew Crosland |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Rocha, Gustavo Machado Machado, Carla Jorge Acurcio, Francisco de Assis Guimarães, Mark Drew Crosland |
dc.subject.por.fl_str_mv |
Anti-Retroviral Agents Acquired Immunodeficiency Syndrome Viral Load CD4 Lymphocyte Count Medication Adherence |
topic |
Anti-Retroviral Agents Acquired Immunodeficiency Syndrome Viral Load CD4 Lymphocyte Count Medication Adherence |
description |
The aim of this study was to describe the effect of non-adherence on the main laboratory outcomes, TCD4+ lymphocyte count and viral load, routinely used to monitor patients initiating treatment according to three different approaches to measure adherence to antiretroviral therapy. Among 288 participants, 22.9%, 31.9% and 74.3% were considered non-adherent, according to medical charts, self-report and pharmacy records, respectively. Depending on the adherence measures used, the average gain in TCD4+ lymphocyte count ranged from 142.4 to 195.4 cells/mm3 among adherent patients, and from 58.5 to 99.8 lymphocytes TCD4+/mm3 among those non-adherent. The average reduction on viral load ranged from 4.25 to 4.62 log copies/mL among the adherent patients, and from 1.99 to 4.07 log among those non-adherent. Monitoring antiretroviral adherence should be considered a priority in these public AIDS referral centers in order to identify patients at high risk of developing virologic failure. Early interventions are necessary in order to maintain the initial therapeutic regimens for longer periods. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781/9759 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4781/9760 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 27 No. 13 (2011): Supplement 1 Cadernos de Saúde Pública; v. 27 n. 13 (2011): Suplemento 1 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1798943370570104832 |