Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil

Detalhes bibliográficos
Autor(a) principal: Costa, Carlos Henrique Nery
Data de Publicação: 2008
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498
Resumo: The available hypotheses or explanations for the urbanization of American visceral leishmaniasis are insufficient. An alternative hypothesis is that changes in the ecology and biology of the vector, Lutzomyia longipalpis, might explain all the new urban epidemiological features of the disease. To tackle the knowledge gaps in this process, certain key research areas need to be prioritized: the role of dogs in expanding transmission in cities, community trials to evaluate new insecticides, and research on the ecological and molecular determinants of Leishmania chagasi transmission. Investment of public funds should focus on the development of a human vaccine, since such a vaccine now appears to be within reach. Even small effects from a vaccine could substantially reduce the impact of the disease, which in the last quarter century has challenged and defeated both the scientific community and the public health field around the world.
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spelling Characterization and speculations on the urbanization of visceral leishmaniasis in BrazilVisceral LeishmaniasisUrbanizationVaccinesThe available hypotheses or explanations for the urbanization of American visceral leishmaniasis are insufficient. An alternative hypothesis is that changes in the ecology and biology of the vector, Lutzomyia longipalpis, might explain all the new urban epidemiological features of the disease. To tackle the knowledge gaps in this process, certain key research areas need to be prioritized: the role of dogs in expanding transmission in cities, community trials to evaluate new insecticides, and research on the ecological and molecular determinants of Leishmania chagasi transmission. Investment of public funds should focus on the development of a human vaccine, since such a vaccine now appears to be within reach. Even small effects from a vaccine could substantially reduce the impact of the disease, which in the last quarter century has challenged and defeated both the scientific community and the public health field around the world.As hipóteses ou explicações apresentadas até o momento para o processo de urbanização da leishmaniose visceral americana são insatisfatórias. Uma hipótese alternativa é a de que mudanças na ecologia e biologia do vetor, Lutzomyia longipalpis, poderiam explicar as feições epidemiológicas urbanas da doença. De forma a suprir lacunas no conhecimento sobre esse processo de urbanização, destacam-se algumas linhas de pesquisa prioritárias: a investigação do papel de cães na amplificação da transmissão da doença nas cidades, ensaios de campo com novos inseticidas, investigação dos determinantes ecológicos ou moleculares que participam da transmissão de Leishmania chagasi. Esforços com investimentos públicos devem ser feitos para o desenvolvimento de vacinas para humanos, pois uma vacina não parece estar tão distante. Resultados vacinais mesmo modestos podem reduzir substancialmente o impacto dessa doença que, no último quarto de século, desafiou e venceu a ciência e a saúde pública mundo afora.Reports in Public HealthCadernos de Saúde Pública2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498Reports in Public Health; Vol. 24 No. 12 (2008): DecemberCadernos de Saúde Pública; v. 24 n. 12 (2008): Dezembro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498/7081https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498/7082Costa, Carlos Henrique Neryinfo:eu-repo/semantics/openAccess2024-03-06T15:27:37Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/3498Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:04:01.743016Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
title Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
spellingShingle Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
Costa, Carlos Henrique Nery
Visceral Leishmaniasis
Urbanization
Vaccines
title_short Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
title_full Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
title_fullStr Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
title_full_unstemmed Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
title_sort Characterization and speculations on the urbanization of visceral leishmaniasis in Brazil
author Costa, Carlos Henrique Nery
author_facet Costa, Carlos Henrique Nery
author_role author
dc.contributor.author.fl_str_mv Costa, Carlos Henrique Nery
dc.subject.por.fl_str_mv Visceral Leishmaniasis
Urbanization
Vaccines
topic Visceral Leishmaniasis
Urbanization
Vaccines
description The available hypotheses or explanations for the urbanization of American visceral leishmaniasis are insufficient. An alternative hypothesis is that changes in the ecology and biology of the vector, Lutzomyia longipalpis, might explain all the new urban epidemiological features of the disease. To tackle the knowledge gaps in this process, certain key research areas need to be prioritized: the role of dogs in expanding transmission in cities, community trials to evaluate new insecticides, and research on the ecological and molecular determinants of Leishmania chagasi transmission. Investment of public funds should focus on the development of a human vaccine, since such a vaccine now appears to be within reach. Even small effects from a vaccine could substantially reduce the impact of the disease, which in the last quarter century has challenged and defeated both the scientific community and the public health field around the world.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498/7081
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3498/7082
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 24 No. 12 (2008): December
Cadernos de Saúde Pública; v. 24 n. 12 (2008): Dezembro
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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