Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200152 |
Resumo: | Abstract Bone development and growth is a non-going, life-long process, varying greatly among individuals and much of this variation could be modulated by genetic factors. The purpose of this study was to evaluate the association between the polymorphisms in the TNF-a gene and skeletal class II malocclusion. Single nucleotide polymorphisms in TNF-a (rs1799724; rs1800629) gene were studied in 79 skeletal class II malocclusion and 102 skeletal class I malocclusion subjects from Straight Wire Group of Studies on Orthodontics and Functional Orthopedics for Maxillary from Rio de Janeiro, Brazil. The Genotyping of these selected polymorphisms was carried out by TaqMan real-time PCR using genomic DNA extracted from buccal cells. All allele and genotype frequencies were compared between the groups using the PLINK® software in a free, in a dominant and in a recessive model using a chi-square test (p≤0.05). There was no significant association of TNF-a (rs1799724; rs1800629) genotype and allele distribution with skeletal class II malocclusion. Regardless of the dominant or recessive genetic model, the preferential genotype associations for rs1799724 and rs1800629 was insignificant. In conclusion, no evidence of association is apparent between genetic polymorphisms involving TNF-a and skeletal class II malocclusion or the position of the maxilla and mandible in the postero-anterior direction. |
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Brazilian Dental Journal |
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Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II MalocclusionmalocclusiongeneticspolymorphismTNF-aAbstract Bone development and growth is a non-going, life-long process, varying greatly among individuals and much of this variation could be modulated by genetic factors. The purpose of this study was to evaluate the association between the polymorphisms in the TNF-a gene and skeletal class II malocclusion. Single nucleotide polymorphisms in TNF-a (rs1799724; rs1800629) gene were studied in 79 skeletal class II malocclusion and 102 skeletal class I malocclusion subjects from Straight Wire Group of Studies on Orthodontics and Functional Orthopedics for Maxillary from Rio de Janeiro, Brazil. The Genotyping of these selected polymorphisms was carried out by TaqMan real-time PCR using genomic DNA extracted from buccal cells. All allele and genotype frequencies were compared between the groups using the PLINK® software in a free, in a dominant and in a recessive model using a chi-square test (p≤0.05). There was no significant association of TNF-a (rs1799724; rs1800629) genotype and allele distribution with skeletal class II malocclusion. Regardless of the dominant or recessive genetic model, the preferential genotype associations for rs1799724 and rs1800629 was insignificant. In conclusion, no evidence of association is apparent between genetic polymorphisms involving TNF-a and skeletal class II malocclusion or the position of the maxilla and mandible in the postero-anterior direction.Fundação Odontológica de Ribeirão Preto2019-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200152Brazilian Dental Journal v.30 n.2 2019reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201902367info:eu-repo/semantics/openAccessLevy,Simone CarvalhoAntunes,Lívia Azeredo AlvesAbreu,Julia Guimaraes Barcellos deNascimento,Jullia Assis da SilvaKuntz,Ana CarolinaFialho,Walter Luis SoaresRodrigues,Amanda SilvaTeixeira,Ellen CardosoCalasans-Maia,José de AlbuquerqueAraújo,Marcelo Calvo deKüchler,Erika C.Antunes,Leonardo Santoseng2019-04-03T00:00:00Zoai:scielo:S0103-64402019000200152Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2019-04-03T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
title |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
spellingShingle |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion Levy,Simone Carvalho malocclusion genetics polymorphism TNF-a |
title_short |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
title_full |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
title_fullStr |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
title_full_unstemmed |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
title_sort |
Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion |
author |
Levy,Simone Carvalho |
author_facet |
Levy,Simone Carvalho Antunes,Lívia Azeredo Alves Abreu,Julia Guimaraes Barcellos de Nascimento,Jullia Assis da Silva Kuntz,Ana Carolina Fialho,Walter Luis Soares Rodrigues,Amanda Silva Teixeira,Ellen Cardoso Calasans-Maia,José de Albuquerque Araújo,Marcelo Calvo de Küchler,Erika C. Antunes,Leonardo Santos |
author_role |
author |
author2 |
Antunes,Lívia Azeredo Alves Abreu,Julia Guimaraes Barcellos de Nascimento,Jullia Assis da Silva Kuntz,Ana Carolina Fialho,Walter Luis Soares Rodrigues,Amanda Silva Teixeira,Ellen Cardoso Calasans-Maia,José de Albuquerque Araújo,Marcelo Calvo de Küchler,Erika C. Antunes,Leonardo Santos |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Levy,Simone Carvalho Antunes,Lívia Azeredo Alves Abreu,Julia Guimaraes Barcellos de Nascimento,Jullia Assis da Silva Kuntz,Ana Carolina Fialho,Walter Luis Soares Rodrigues,Amanda Silva Teixeira,Ellen Cardoso Calasans-Maia,José de Albuquerque Araújo,Marcelo Calvo de Küchler,Erika C. Antunes,Leonardo Santos |
dc.subject.por.fl_str_mv |
malocclusion genetics polymorphism TNF-a |
topic |
malocclusion genetics polymorphism TNF-a |
description |
Abstract Bone development and growth is a non-going, life-long process, varying greatly among individuals and much of this variation could be modulated by genetic factors. The purpose of this study was to evaluate the association between the polymorphisms in the TNF-a gene and skeletal class II malocclusion. Single nucleotide polymorphisms in TNF-a (rs1799724; rs1800629) gene were studied in 79 skeletal class II malocclusion and 102 skeletal class I malocclusion subjects from Straight Wire Group of Studies on Orthodontics and Functional Orthopedics for Maxillary from Rio de Janeiro, Brazil. The Genotyping of these selected polymorphisms was carried out by TaqMan real-time PCR using genomic DNA extracted from buccal cells. All allele and genotype frequencies were compared between the groups using the PLINK® software in a free, in a dominant and in a recessive model using a chi-square test (p≤0.05). There was no significant association of TNF-a (rs1799724; rs1800629) genotype and allele distribution with skeletal class II malocclusion. Regardless of the dominant or recessive genetic model, the preferential genotype associations for rs1799724 and rs1800629 was insignificant. In conclusion, no evidence of association is apparent between genetic polymorphisms involving TNF-a and skeletal class II malocclusion or the position of the maxilla and mandible in the postero-anterior direction. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200152 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200152 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440201902367 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.30 n.2 2019 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204095362629632 |