Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200077 |
Resumo: | Abstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods. |
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Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping ReviewRegenerative therapymesenchymal stem celltissue engineeringrevascularization root canalscaffoldscell therapyplatelet-rich fibrinplatelet-rich plasmAbstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods.Fundação Odontológica de Ribeirão Preto2019-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200077Brazilian Dental Journal v.30 n.2 2019reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201902053info:eu-repo/semantics/openAccessChisini,Luiz AlexandreConde,Marcus Cristian MunizGrazioli,GuillermoMartin,Alissa Schmidt SanCarvalho,Rodrigo Varella deSartori,Letícia Regina MorelloDemarco,Flávio Fernandoeng2019-04-09T00:00:00Zoai:scielo:S0103-64402019000200077Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2019-04-09T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
title |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
spellingShingle |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review Chisini,Luiz Alexandre Regenerative therapy mesenchymal stem cell tissue engineering revascularization root canal scaffolds cell therapy platelet-rich fibrin platelet-rich plasm |
title_short |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
title_full |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
title_fullStr |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
title_full_unstemmed |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
title_sort |
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review |
author |
Chisini,Luiz Alexandre |
author_facet |
Chisini,Luiz Alexandre Conde,Marcus Cristian Muniz Grazioli,Guillermo Martin,Alissa Schmidt San Carvalho,Rodrigo Varella de Sartori,Letícia Regina Morello Demarco,Flávio Fernando |
author_role |
author |
author2 |
Conde,Marcus Cristian Muniz Grazioli,Guillermo Martin,Alissa Schmidt San Carvalho,Rodrigo Varella de Sartori,Letícia Regina Morello Demarco,Flávio Fernando |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Chisini,Luiz Alexandre Conde,Marcus Cristian Muniz Grazioli,Guillermo Martin,Alissa Schmidt San Carvalho,Rodrigo Varella de Sartori,Letícia Regina Morello Demarco,Flávio Fernando |
dc.subject.por.fl_str_mv |
Regenerative therapy mesenchymal stem cell tissue engineering revascularization root canal scaffolds cell therapy platelet-rich fibrin platelet-rich plasm |
topic |
Regenerative therapy mesenchymal stem cell tissue engineering revascularization root canal scaffolds cell therapy platelet-rich fibrin platelet-rich plasm |
description |
Abstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200077 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402019000200077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440201902053 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.30 n.2 2019 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204095346900992 |