Improving tuberculosis control through the partnership between university and the health system
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/3976 |
Resumo: | Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. Methods: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units–variable number tandem repeat. Results: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. Conclusions: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control. |
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Valença, Mariana SoaresRocha, Jeane Zanini daRamis, Ivy BastosCarrion, Lillian LucasMadruga, Catiúcia Figueiredo GorisMacedo, Maíra Bidart deScaini, Carlos JamesGroll, Andrea VonSilva, Pedro Eduardo Almeida da2013-10-12T02:40:26Z2013-10-12T02:40:26Z2012VALENÇA, Mariana Soares et al. Improving tuberculosis control through the partnership between university and the health system. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 4, p. 491-495, 2012. Disponível em: <http://www.scielo.br/pdf/rsbmt/v45n4/aop58-2012.pdf>. Acesso em: 11 out. 2013.http://repositorio.furg.br/handle/1/3976Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. Methods: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units–variable number tandem repeat. Results: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. Conclusions: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control.O controle da tuberculose (TB) está relacionado com a disponibilidade de métodos de diagnóstico microbiológico qualificados, no entanto a microscopia com a sua limitada sensibilidade é o único método disponível em muitos locais.O objetivo deste estudo foi avaliar a introdução da cultura, teste de sensibilidade aos antimicrobianos (TSA) e genotipagem na rotina de um Programa Municipal de Controle da Tuberculose. Métodos:A baciloscopia direta do escarro e cultura em Ogawa-Kudoh foram realizadas em 1.636 amostras de 787 pacientes. O TSA das culturas positivas foi realizado pelo método de microdiluição e a genotipagem por Mycobacterial Interspersed Repetitive Units – Variable Number Tandem Repeat (MIRU-VNTR). Resultados: Foram identificados 91 pacientes com TB, com a cultura aumentando em 32% a detecção de casos em comparação com a microscopia; a resistência adquirida foi de 3,3% e a genotipagem mostrou alta diversidade genética. Conclusões: O cultivo em Ogawa-Kudoh contribuiu significativamente para o aumento na detecção de casos e é adequado para ser implementado em locais com poucos recursos. A taxa de resistência adquirida foi menor do que a relatada em recente inquérito nacional. A alta diversidade genética está possivelmente relacionada à alevada prevalência de TB na população, detecção precoce e tratamento adequado dos pacientes.A interação entre a pesquisa e serviço de saúde pública é importante para reorientar a prática, transferir tecnologia e melhorar o controle da TB.engMycobacterium tuberculosisDiagnosticMolecular epidemiologyDiagnósticoEpidemiologia molecularImproving tuberculosis control through the partnership between university and the health systemQualificar o controle da tuberculose mediante a parceria entre a universidade e o sistema de saúdeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALImproving tuberculosis control through the partnership between.pdfImproving tuberculosis control through the partnership between.pdfapplication/pdf695939https://repositorio.furg.br/bitstream/1/3976/1/Improving%20tuberculosis%20control%20through%20the%20partnership%20between.pdf6ba650d5d286f7c97399666607ab38adMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81678https://repositorio.furg.br/bitstream/1/3976/2/license.txtd3be63d3b3eee02729709361dac69efeMD52open access1/39762013-10-11 23:40:26.71open accessoai:repositorio.furg.br:1/397677+9IG5lY2Vzc++/vXJpbyBjb25jb3JkYXIgY29tIGEgbGljZW7vv71hIGRlIGRpc3RyaWJ1ae+/ve+/vW8gbu+/vW8tZXhjbHVzaXZhLAphbnRlcyBxdWUgbyBkb2N1bWVudG8gcG9zc2EgYXBhcmVjZXIgbm8gUmVwb3NpdO+/vXJpby4gUG9yIGZhdm9yLCBsZWlhIGEKbGljZW7vv71hIGF0ZW50YW1lbnRlLiBDYXNvIG5lY2Vzc2l0ZSBkZSBhbGd1bSBlc2NsYXJlY2ltZW50byBlbnRyZSBlbQpjb250YXRvIGF0cmF277+9cyBkZTogcmVwb3NpdG9yaW9AZnVyZy5iciBvdSAweHggNTMgMzIzMy02NzA2LgoKTElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBCgpBbyBhc3NpbmFyIGUgZW50cmVnYXIgZXN0YSBsaWNlbu+/vWEsIG8vYSBTci4vU3JhLiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKToKCmEpIENvbmNlZGUg77+9IFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRlIFJpbyBHcmFuZGUgLSAgRlVSRyBvIGRpcmVpdG8gbu+/vW8tZXhjbHVzaXZvIGRlIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhYmFpeG8pLCBjb211bmljYXIgZS9vdSBkaXN0cmlidWlyIG8gZG9jdW1lbnRvIGVudHJlZ3VlIChpbmNsdWluZG8gbyByZXN1bW8vYWJzdHJhY3QpIGVtCmZvcm1hdG8gZGlnaXRhbCBvdSBpbXByZXNzbyBlIGVtIHF1YWxxdWVyIG1laW8uCgpiKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDvv70gc2V1IHRyYWJhbGhvIG9yaWdpbmFsLCBlIHF1ZQpkZXTvv71tIG8gZGlyZWl0byBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbu+/vWEuIERlY2xhcmEgdGFtYu+/vW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbu+/vW8gaW5mcmluZ2UsIHRhbnRvIHF1YW50byBsaGUg77+9IHBvc3Pvv712ZWwgc2FiZXIsIG9zIGRpcmVpdG9zIGRlIHF1YWxxdWVyIG91dHJhIHBlc3NvYSBvdSBlbnRpZGFkZS4KCmMpIFNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIGNvbnTvv71tIG1hdGVyaWFsIGRvIHF1YWwgbu+/vW8gZGV077+9bSBvcwpkaXJlaXRvcyBkZSBhdXRvciwgZGVjbGFyYSBxdWUgb2J0ZXZlIGF1dG9yaXph77+977+9byBkbyBkZXRlbnRvciBkb3MKZGlyZWl0b3MgZGUgYXV0b3IgcGFyYSBjb25jZWRlciDvv70gRlVSRyBvcyBkaXJlaXRvcyByZXF1ZXJpZG9zIHBvciBlc3RhIGxpY2Vu77+9YSwgZSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBz77+9byBkZSB0ZXJjZWlyb3MgZXN077+9IGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3UgY29udGXvv71kbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpTZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDvv70gYmFzZWFkbyBlbSB0cmFiYWxobyBmaW5hbmNpYWRvIG91IGFwb2lhZG8KcG9yIG91dHJhIGluc3RpdHVp77+977+9byBxdWUgbu+/vW8gYSBGVVJHLCBkZWNsYXJhIHF1ZSBjdW1wcml1IHF1YWlzcXVlciBvYnJpZ2Hvv73vv71lcyBleGlnaWRhcyBwZWxvIHJlc3BlY3Rpdm8gY29udHJhdG8gb3UgYWNvcmRvLgoKQSBGVVJHIGlkZW50aWZpY2Fy77+9IGNsYXJhbWVudGUgbyhzKSBzZXUgKHMpIG5vbWUgKHMpIGNvbW8gbyAocykgYXV0b3IgKGVzKSBvdSBkZXRlbnRvciAoZXMpIGRvcyBkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUsIGUgbu+/vW8gZmFy77+9IHF1YWxxdWVyIGFsdGVyYe+/ve+/vW8sIHBhcmEgYWzvv71tIGRhcyBwZXJtaXRpZGFzIHBvciBlc3RhIGxpY2Vu77+9YS4KRepositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2013-10-12T02:40:26Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Improving tuberculosis control through the partnership between university and the health system |
dc.title.alternative.pt_BR.fl_str_mv |
Qualificar o controle da tuberculose mediante a parceria entre a universidade e o sistema de saúde |
title |
Improving tuberculosis control through the partnership between university and the health system |
spellingShingle |
Improving tuberculosis control through the partnership between university and the health system Valença, Mariana Soares Mycobacterium tuberculosis Diagnostic Molecular epidemiology Diagnóstico Epidemiologia molecular |
title_short |
Improving tuberculosis control through the partnership between university and the health system |
title_full |
Improving tuberculosis control through the partnership between university and the health system |
title_fullStr |
Improving tuberculosis control through the partnership between university and the health system |
title_full_unstemmed |
Improving tuberculosis control through the partnership between university and the health system |
title_sort |
Improving tuberculosis control through the partnership between university and the health system |
author |
Valença, Mariana Soares |
author_facet |
Valença, Mariana Soares Rocha, Jeane Zanini da Ramis, Ivy Bastos Carrion, Lillian Lucas Madruga, Catiúcia Figueiredo Goris Macedo, Maíra Bidart de Scaini, Carlos James Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author_role |
author |
author2 |
Rocha, Jeane Zanini da Ramis, Ivy Bastos Carrion, Lillian Lucas Madruga, Catiúcia Figueiredo Goris Macedo, Maíra Bidart de Scaini, Carlos James Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Valença, Mariana Soares Rocha, Jeane Zanini da Ramis, Ivy Bastos Carrion, Lillian Lucas Madruga, Catiúcia Figueiredo Goris Macedo, Maíra Bidart de Scaini, Carlos James Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
dc.subject.por.fl_str_mv |
Mycobacterium tuberculosis Diagnostic Molecular epidemiology Diagnóstico Epidemiologia molecular |
topic |
Mycobacterium tuberculosis Diagnostic Molecular epidemiology Diagnóstico Epidemiologia molecular |
description |
Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. Methods: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units–variable number tandem repeat. Results: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. Conclusions: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2013-10-12T02:40:26Z |
dc.date.available.fl_str_mv |
2013-10-12T02:40:26Z |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
VALENÇA, Mariana Soares et al. Improving tuberculosis control through the partnership between university and the health system. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 4, p. 491-495, 2012. Disponível em: <http://www.scielo.br/pdf/rsbmt/v45n4/aop58-2012.pdf>. Acesso em: 11 out. 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/3976 |
identifier_str_mv |
VALENÇA, Mariana Soares et al. Improving tuberculosis control through the partnership between university and the health system. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 4, p. 491-495, 2012. Disponível em: <http://www.scielo.br/pdf/rsbmt/v45n4/aop58-2012.pdf>. Acesso em: 11 out. 2013. |
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