Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil

Detalhes bibliográficos
Autor(a) principal: Gióia, Carolina Alicia Coch
Data de Publicação: 2015
Outros Autores: Lemos, Ana Paula Silva de, Gorla, Maria Cecilia Outeiro, Mendoza-Sassi, Raul Andrés, Ballester, Teresa, Groll, Andrea Von, Wedig, Bruna Laís, Ethur, Nathalia de Vargas, Bragança, Letícia, Milagres, Lucimar Gonçalves, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7013
http://dx.doi.org/10.1016/j.ram.2015.08.004
Resumo: Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required.
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spelling Gióia, Carolina Alicia CochLemos, Ana Paula Silva deGorla, Maria Cecilia OuteiroMendoza-Sassi, Raul AndrésBallester, TeresaGroll, Andrea VonWedig, Bruna LaísEthur, Nathalia de VargasBragança, LetíciaMilagres, Lucimar GonçalvesSilva, Pedro Eduardo Almeida da2017-01-15T19:28:51Z2017-01-15T19:28:51Z2015GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017.1851-7617http://repositorio.furg.br/handle/1/7013http://dx.doi.org/10.1016/j.ram.2015.08.004Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required.Los portadores asintomáticos de meningococos en hospitales son un factor de riesgo (FR) para adquirir la enfermedad meningocócica. La frecuencia de portadores de meningococos fue determinada a través de colecta orofaríngea en personal de un hospital de Brasil (n = 200). La prevalencia de portadores fue del 9 % (IC del 95 %, 5-13 %). Los FR asociados al estado de portador fueron los siguientes: edad promedio 26,5 anos, ˜ sexo masculino, hábito de frecuentar bares y número de personas/casa. Entre las 18 cepas de meningococos aisladas, 14 eran no agrupables (NG), 3 correspondieron al serogrupo B y una al 29E. La frecuencia de los serotipos y serosubtipos fue heterogénea, con un ligero predominio de los serotipos 4 y 7 y de los serosubtipos P1.7 y P1.5. La mayoría de las cepas (n = 13) fueron sensibles a los antimicrobianos estudiados. El gen ctrA fue identificado por PCR en 9 (64,3 %) de las 14 cepas NG, lo que sugiere virulencia en la mayoría de las cepas NG aisladas. Por lo tanto, se requiere una vigilancia constante de estos portadores asintomáticos.porNeisseria meningitidisAsymptomatic carriersPrevalenceHospitalAntimicrobialsPCR ctrAPortadores asintomáticosPrevalenciaAntimicrobianosDetection of Neisseria meningitidis in asymptomatic carriers in a university hospital from BrazilDetección de Neisseria meningitidis en portadores asintomáticos en un hospital universitario de Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALv47n4a07.pdfv47n4a07.pdfapplication/pdf347662https://repositorio.furg.br/bitstream/1/7013/1/v47n4a07.pdfc904b61fb61ec1c6f963a17734d6a040MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7013/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/70132019-11-13 22:48:31.132open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-14T01:48:31Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
dc.title.alternative.pt_BR.fl_str_mv Detección de Neisseria meningitidis en portadores asintomáticos en un hospital universitario de Brasil
title Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
spellingShingle Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
Gióia, Carolina Alicia Coch
Neisseria meningitidis
Asymptomatic carriers
Prevalence
Hospital
Antimicrobials
PCR ctrA
Portadores asintomáticos
Prevalencia
Antimicrobianos
title_short Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
title_full Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
title_fullStr Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
title_full_unstemmed Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
title_sort Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
author Gióia, Carolina Alicia Coch
author_facet Gióia, Carolina Alicia Coch
Lemos, Ana Paula Silva de
Gorla, Maria Cecilia Outeiro
Mendoza-Sassi, Raul Andrés
Ballester, Teresa
Groll, Andrea Von
Wedig, Bruna Laís
Ethur, Nathalia de Vargas
Bragança, Letícia
Milagres, Lucimar Gonçalves
Silva, Pedro Eduardo Almeida da
author_role author
author2 Lemos, Ana Paula Silva de
Gorla, Maria Cecilia Outeiro
Mendoza-Sassi, Raul Andrés
Ballester, Teresa
Groll, Andrea Von
Wedig, Bruna Laís
Ethur, Nathalia de Vargas
Bragança, Letícia
Milagres, Lucimar Gonçalves
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gióia, Carolina Alicia Coch
Lemos, Ana Paula Silva de
Gorla, Maria Cecilia Outeiro
Mendoza-Sassi, Raul Andrés
Ballester, Teresa
Groll, Andrea Von
Wedig, Bruna Laís
Ethur, Nathalia de Vargas
Bragança, Letícia
Milagres, Lucimar Gonçalves
Silva, Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv Neisseria meningitidis
Asymptomatic carriers
Prevalence
Hospital
Antimicrobials
PCR ctrA
Portadores asintomáticos
Prevalencia
Antimicrobianos
topic Neisseria meningitidis
Asymptomatic carriers
Prevalence
Hospital
Antimicrobials
PCR ctrA
Portadores asintomáticos
Prevalencia
Antimicrobianos
description Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-01-15T19:28:51Z
dc.date.available.fl_str_mv 2017-01-15T19:28:51Z
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dc.identifier.citation.fl_str_mv GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/7013
dc.identifier.issn.none.fl_str_mv 1851-7617
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.ram.2015.08.004
identifier_str_mv GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017.
1851-7617
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