Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7024 http://dx.doi.org/10.1590/S1517-83822013000400032 |
Resumo: | A sublineage of Mycobacterium tuberculosis called RDRio was described in 2007. Although only recently described, this strain may have been present previously in the population, and its identification in clinical isolates will elucidate bacterial transmission dynamics and host-pathogen interactions. This study evaluated the clonal diversity of the RDRio sublineage in clinical isolates from Rio Grande-RS obtained between 1998 and 2001. Among the 45 samples analyzed by the MIRU-VNTR method, there were six clusters with two samples each and 33 orphan strains with unique pattern. The strains were distributed across several different lineages including LAM (34.04%), X (14.89%), Haarlem (12.77%), UgandaI (10.64%), S (4.26%), NEW-1 (2.13%) and Cameroon (2.13%); 14.89% of the strains matched to multiple lineages. RDRio strains were present in 28.9% of the samples and 81.25% of the identified strains belonged to the LAM family. The high clonal diversity observed in this study is a constant feature in this region. The RDRio sublineage has been in Rio Grande-RS since 1998. The continued monitoring of RDRio in clinical isolates will enhance the understanding of its epidemiological significance. |
id |
FURG_9b62390101ca8b983889d7ce96d03b8d |
---|---|
oai_identifier_str |
oai:repositorio.furg.br:1/7024 |
network_acronym_str |
FURG |
network_name_str |
Repositório Institucional da FURG (RI FURG) |
repository_id_str |
|
spelling |
Soares, Renata OliveiraMacedo, Maíra Bidart deGroll, Andrea VonSilva, Pedro Eduardo Almeida da2017-01-17T03:30:30Z2017-01-17T03:30:30Z2013SOARES, Renata Oliveira et al. Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years. Brazilian Journal of Microbiology, v. 44, n. 4, p. 1251-1255, 2013. Disponível em: <http://dx.doi.org/10.1590/S1517-83822013000400032 >. Acesso em: 16 jan. 2017.1678-4405http://repositorio.furg.br/handle/1/7024http://dx.doi.org/10.1590/S1517-83822013000400032A sublineage of Mycobacterium tuberculosis called RDRio was described in 2007. Although only recently described, this strain may have been present previously in the population, and its identification in clinical isolates will elucidate bacterial transmission dynamics and host-pathogen interactions. This study evaluated the clonal diversity of the RDRio sublineage in clinical isolates from Rio Grande-RS obtained between 1998 and 2001. Among the 45 samples analyzed by the MIRU-VNTR method, there were six clusters with two samples each and 33 orphan strains with unique pattern. The strains were distributed across several different lineages including LAM (34.04%), X (14.89%), Haarlem (12.77%), UgandaI (10.64%), S (4.26%), NEW-1 (2.13%) and Cameroon (2.13%); 14.89% of the strains matched to multiple lineages. RDRio strains were present in 28.9% of the samples and 81.25% of the identified strains belonged to the LAM family. The high clonal diversity observed in this study is a constant feature in this region. The RDRio sublineage has been in Rio Grande-RS since 1998. The continued monitoring of RDRio in clinical isolates will enhance the understanding of its epidemiological significance.engMycobacterium tuberculosisMIRU-VNTRRDRioMycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 yearsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINAL32.pdf32.pdfapplication/pdf726889https://repositorio.furg.br/bitstream/1/7024/1/32.pdf7615e9509042a6f36e91da79855396e9MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7024/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/70242019-11-13 23:02:08.775open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-14T02:02:08Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
title |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
spellingShingle |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years Soares, Renata Oliveira Mycobacterium tuberculosis MIRU-VNTR RDRio |
title_short |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
title_full |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
title_fullStr |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
title_full_unstemmed |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
title_sort |
Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years |
author |
Soares, Renata Oliveira |
author_facet |
Soares, Renata Oliveira Macedo, Maíra Bidart de Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author_role |
author |
author2 |
Macedo, Maíra Bidart de Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Soares, Renata Oliveira Macedo, Maíra Bidart de Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
dc.subject.por.fl_str_mv |
Mycobacterium tuberculosis MIRU-VNTR RDRio |
topic |
Mycobacterium tuberculosis MIRU-VNTR RDRio |
description |
A sublineage of Mycobacterium tuberculosis called RDRio was described in 2007. Although only recently described, this strain may have been present previously in the population, and its identification in clinical isolates will elucidate bacterial transmission dynamics and host-pathogen interactions. This study evaluated the clonal diversity of the RDRio sublineage in clinical isolates from Rio Grande-RS obtained between 1998 and 2001. Among the 45 samples analyzed by the MIRU-VNTR method, there were six clusters with two samples each and 33 orphan strains with unique pattern. The strains were distributed across several different lineages including LAM (34.04%), X (14.89%), Haarlem (12.77%), UgandaI (10.64%), S (4.26%), NEW-1 (2.13%) and Cameroon (2.13%); 14.89% of the strains matched to multiple lineages. RDRio strains were present in 28.9% of the samples and 81.25% of the identified strains belonged to the LAM family. The high clonal diversity observed in this study is a constant feature in this region. The RDRio sublineage has been in Rio Grande-RS since 1998. The continued monitoring of RDRio in clinical isolates will enhance the understanding of its epidemiological significance. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2017-01-17T03:30:30Z |
dc.date.available.fl_str_mv |
2017-01-17T03:30:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOARES, Renata Oliveira et al. Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years. Brazilian Journal of Microbiology, v. 44, n. 4, p. 1251-1255, 2013. Disponível em: <http://dx.doi.org/10.1590/S1517-83822013000400032 >. Acesso em: 16 jan. 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/7024 |
dc.identifier.issn.none.fl_str_mv |
1678-4405 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/S1517-83822013000400032 |
identifier_str_mv |
SOARES, Renata Oliveira et al. Mycobacterium tuberculosis belonging to family LAM and sublineage RDRio: common strains in southern Brazil for over 10 years. Brazilian Journal of Microbiology, v. 44, n. 4, p. 1251-1255, 2013. Disponível em: <http://dx.doi.org/10.1590/S1517-83822013000400032 >. Acesso em: 16 jan. 2017. 1678-4405 |
url |
http://repositorio.furg.br/handle/1/7024 http://dx.doi.org/10.1590/S1517-83822013000400032 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
institution |
FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
bitstream.url.fl_str_mv |
https://repositorio.furg.br/bitstream/1/7024/1/32.pdf https://repositorio.furg.br/bitstream/1/7024/2/license.txt |
bitstream.checksum.fl_str_mv |
7615e9509042a6f36e91da79855396e9 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
|
_version_ |
1798313609822994432 |