Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

Detalhes bibliográficos
Autor(a) principal: Cardoso, Liziane Vaz
Data de Publicação: 2011
Outros Autores: Tomasini, Débora, Sampaio, Maicon Renato Ferreira, Barbosa, Sergiane Caldas, Kleemann, Natiele, Primel, Ednei Gilberto, Gonçalves, Fábio Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/1712
Resumo: Neste trabalho, foi desenvolvido e validado um método analítico baseado na extração em fase sólida(SPE) e cromatografia líquida acoplada a espectrometria de massas em tandem (LC-APCI-MS/MS)para a determinação e confirmação de cinco fármacos em amostras de água. Os limites de detecção(LOD) variaram de 0,053 a 0,53 μg L-1 e os limites de quantificação (LOQ) de 0,16 a 1,6 μg L-1. Foi obtida boa linearidade com r > 0,99 para todos os compostos. As recuperações dos compostos variaram de 70 a 120%, com desvios padrão relativos (RSD) menores que 20% para todos. Através do monitoramento de reações múltiplas (MRM), foram selecionadas duas transições diferentes íon precursor-íon produto para cada fármaco.
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spelling Cardoso, Liziane VazTomasini, DéboraSampaio, Maicon Renato FerreiraBarbosa, Sergiane CaldasKleemann, NatielePrimel, Ednei GilbertoGonçalves, Fábio Ferreira2012-01-07T23:28:23Z2012-01-07T23:28:23Z2011CARDOSO, Liziane Vaz et al. Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water. Journal of the Brazilian Chemical Society, v. 22, n. 10, p. 1944-1952, 2011. Disponível em: <http://www.scielo.br/pdf/jbchs/v22n10/v22n10a16.pdf> Acesso em: 29 dez. 2011.0103-5053http://repositorio.furg.br/handle/1/1712Neste trabalho, foi desenvolvido e validado um método analítico baseado na extração em fase sólida(SPE) e cromatografia líquida acoplada a espectrometria de massas em tandem (LC-APCI-MS/MS)para a determinação e confirmação de cinco fármacos em amostras de água. Os limites de detecção(LOD) variaram de 0,053 a 0,53 μg L-1 e os limites de quantificação (LOQ) de 0,16 a 1,6 μg L-1. Foi obtida boa linearidade com r > 0,99 para todos os compostos. As recuperações dos compostos variaram de 70 a 120%, com desvios padrão relativos (RSD) menores que 20% para todos. Através do monitoramento de reações múltiplas (MRM), foram selecionadas duas transições diferentes íon precursor-íon produto para cada fármaco.In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to 0.53 μg L-1 and the limits of quantification (LOQ) from 0.16 to 1.6 μg L-1. Good linearity was obtained with r > 0.99 for all compounds. The recoveries of the compounds ranged from 70 to 120% with relative standard deviations (RSD) below 20% for all. Through multiple reactions monitoring (MRM) two different transitions, precursor ion-product ion, were selected for each pharmaceutical.engMethod validationSPELC-APCI-MS/MSEmergent contaminantsOptimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply waterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALOptimization and Validation of a Method using SPE and LC-APC....pdfOptimization and Validation of a Method using SPE and LC-APC....pdfapplication/pdf445625https://repositorio.furg.br/bitstream/1/1712/1/Optimization%20and%20Validation%20of%20a%20Method%20using%20SPE%20and%20LC-APC....pdf71082ab213e5314f1ef876d5e4e8ea9cMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81724https://repositorio.furg.br/bitstream/1/1712/2/license.txt5b92b9704b4f13242d70e45ddef35a68MD52open access1/17122019-11-13 20:45:22.707open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-13T23:45:22Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
title Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
spellingShingle Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
Cardoso, Liziane Vaz
Method validation
SPE
LC-APCI-MS/MS
Emergent contaminants
title_short Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
title_full Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
title_fullStr Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
title_full_unstemmed Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
title_sort Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water
author Cardoso, Liziane Vaz
author_facet Cardoso, Liziane Vaz
Tomasini, Débora
Sampaio, Maicon Renato Ferreira
Barbosa, Sergiane Caldas
Kleemann, Natiele
Primel, Ednei Gilberto
Gonçalves, Fábio Ferreira
author_role author
author2 Tomasini, Débora
Sampaio, Maicon Renato Ferreira
Barbosa, Sergiane Caldas
Kleemann, Natiele
Primel, Ednei Gilberto
Gonçalves, Fábio Ferreira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Liziane Vaz
Tomasini, Débora
Sampaio, Maicon Renato Ferreira
Barbosa, Sergiane Caldas
Kleemann, Natiele
Primel, Ednei Gilberto
Gonçalves, Fábio Ferreira
dc.subject.por.fl_str_mv Method validation
SPE
LC-APCI-MS/MS
Emergent contaminants
topic Method validation
SPE
LC-APCI-MS/MS
Emergent contaminants
description Neste trabalho, foi desenvolvido e validado um método analítico baseado na extração em fase sólida(SPE) e cromatografia líquida acoplada a espectrometria de massas em tandem (LC-APCI-MS/MS)para a determinação e confirmação de cinco fármacos em amostras de água. Os limites de detecção(LOD) variaram de 0,053 a 0,53 μg L-1 e os limites de quantificação (LOQ) de 0,16 a 1,6 μg L-1. Foi obtida boa linearidade com r > 0,99 para todos os compostos. As recuperações dos compostos variaram de 70 a 120%, com desvios padrão relativos (RSD) menores que 20% para todos. Através do monitoramento de reações múltiplas (MRM), foram selecionadas duas transições diferentes íon precursor-íon produto para cada fármaco.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-01-07T23:28:23Z
dc.date.available.fl_str_mv 2012-01-07T23:28:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, Liziane Vaz et al. Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water. Journal of the Brazilian Chemical Society, v. 22, n. 10, p. 1944-1952, 2011. Disponível em: <http://www.scielo.br/pdf/jbchs/v22n10/v22n10a16.pdf> Acesso em: 29 dez. 2011.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/1712
dc.identifier.issn.none.fl_str_mv 0103-5053
identifier_str_mv CARDOSO, Liziane Vaz et al. Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water. Journal of the Brazilian Chemical Society, v. 22, n. 10, p. 1944-1952, 2011. Disponível em: <http://www.scielo.br/pdf/jbchs/v22n10/v22n10a16.pdf> Acesso em: 29 dez. 2011.
0103-5053
url http://repositorio.furg.br/handle/1/1712
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instname_str Universidade Federal do Rio Grande (FURG)
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