On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis

Detalhes bibliográficos
Autor(a) principal: Jardim, Guilherme Augusto de Melo
Data de Publicação: 2015
Outros Autores: Cruz, Eduardo Henrique Guimarães da, Valença, Wagner, Resende, Jarbas Magalhães, Rodrigues, Bernardo Lages, Soares, Daniela Fernandes Ramos, Oliveira, Ronaldo, Silva, Pedro Eduardo Almeida da, Silva Júnior, Eufrânio Nunes da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7149
http://dx.doi.org/10.5935/0103-5053.20150067
Resumo: Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes.
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spelling Jardim, Guilherme Augusto de MeloCruz, Eduardo Henrique Guimarães daValença, WagnerResende, Jarbas MagalhãesRodrigues, Bernardo LagesSoares, Daniela Fernandes RamosOliveira, RonaldoSilva, Pedro Eduardo Almeida daSilva Júnior, Eufrânio Nunes da2017-04-27T22:06:09Z2017-04-27T22:06:09Z2015JARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017.0103-5053http://repositorio.furg.br/handle/1/7149http://dx.doi.org/10.5935/0103-5053.20150067Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes.engLapacholPhenazinesMycobacterium tuberculosisAntitubercularTriazolesOn the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINAL0103-5053-jbchs-26-05-1013.pdf0103-5053-jbchs-26-05-1013.pdfapplication/pdf768106https://repositorio.furg.br/bitstream/1/7149/1/0103-5053-jbchs-26-05-1013.pdfc62b851e1a4740e6c9f9ff53a03a5cc8MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7149/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/71492019-12-03 17:26:07.519open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-12-03T20:26:07Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
title On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
spellingShingle On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
Jardim, Guilherme Augusto de Melo
Lapachol
Phenazines
Mycobacterium tuberculosis
Antitubercular
Triazoles
title_short On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
title_full On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
title_fullStr On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
title_full_unstemmed On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
title_sort On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
author Jardim, Guilherme Augusto de Melo
author_facet Jardim, Guilherme Augusto de Melo
Cruz, Eduardo Henrique Guimarães da
Valença, Wagner
Resende, Jarbas Magalhães
Rodrigues, Bernardo Lages
Soares, Daniela Fernandes Ramos
Oliveira, Ronaldo
Silva, Pedro Eduardo Almeida da
Silva Júnior, Eufrânio Nunes da
author_role author
author2 Cruz, Eduardo Henrique Guimarães da
Valença, Wagner
Resende, Jarbas Magalhães
Rodrigues, Bernardo Lages
Soares, Daniela Fernandes Ramos
Oliveira, Ronaldo
Silva, Pedro Eduardo Almeida da
Silva Júnior, Eufrânio Nunes da
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jardim, Guilherme Augusto de Melo
Cruz, Eduardo Henrique Guimarães da
Valença, Wagner
Resende, Jarbas Magalhães
Rodrigues, Bernardo Lages
Soares, Daniela Fernandes Ramos
Oliveira, Ronaldo
Silva, Pedro Eduardo Almeida da
Silva Júnior, Eufrânio Nunes da
dc.subject.por.fl_str_mv Lapachol
Phenazines
Mycobacterium tuberculosis
Antitubercular
Triazoles
topic Lapachol
Phenazines
Mycobacterium tuberculosis
Antitubercular
Triazoles
description Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-04-27T22:06:09Z
dc.date.available.fl_str_mv 2017-04-27T22:06:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/7149
dc.identifier.issn.none.fl_str_mv 0103-5053
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.5935/0103-5053.20150067
identifier_str_mv JARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017.
0103-5053
url http://repositorio.furg.br/handle/1/7149
http://dx.doi.org/10.5935/0103-5053.20150067
dc.language.iso.fl_str_mv eng
language eng
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