Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs
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Publication Date: | 2011 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da FURG (RI FURG) |
Download full: | http://repositorio.furg.br/handle/1/4307 |
Summary: | Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) TB have been described. After the discovery of several drugs with anti-TB activity, multidrug therapy became fundamental for control of the disease. Major advances in molecular biology and the availability of new information generated after sequencing the genome of Mycobacterium tuberculosis increased our knowledge of the mechanisms of resistance to the main anti-TB drugs. Better knowledge of the mechanisms of drug resistance in TB and the molecular mechanisms involved will help us to improve current techniques for rapid detection and will also stimulate the exploration of new targets for drug activity and drug development. This article presents an updated review of the mechanisms and molecular basis of drug resistance in M. tuberculosis. It also comments on the several gaps in our current knowledge of the molecular mechanisms of drug resistance to the main classical and new anti-TB drugs and briefly discusses some implications of the development of drug resistance and fitness, transmission and pathogenicity of M. tuberculosis. |
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Silva, Pedro Eduardo Almeida daPalomino, Juan Carlos2014-01-17T17:26:18Z2014-01-17T17:26:18Z2011SILVA, Pedro Eduardo Almeida da; PALOMINO, Juan Carlos. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs . Journal of Antimicrobial Chemotherapy, v. 66, n. 7, p. 1417-1430, 2011. Disponível em: <http://jac.oxfordjournals.org/content/66/7/1417.full.pdf+html>. Acesso em: 23 dez. 2013.0305-7453http://repositorio.furg.br/handle/1/430710.1093/jac/dkr173Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) TB have been described. After the discovery of several drugs with anti-TB activity, multidrug therapy became fundamental for control of the disease. Major advances in molecular biology and the availability of new information generated after sequencing the genome of Mycobacterium tuberculosis increased our knowledge of the mechanisms of resistance to the main anti-TB drugs. Better knowledge of the mechanisms of drug resistance in TB and the molecular mechanisms involved will help us to improve current techniques for rapid detection and will also stimulate the exploration of new targets for drug activity and drug development. This article presents an updated review of the mechanisms and molecular basis of drug resistance in M. tuberculosis. It also comments on the several gaps in our current knowledge of the molecular mechanisms of drug resistance to the main classical and new anti-TB drugs and briefly discusses some implications of the development of drug resistance and fitness, transmission and pathogenicity of M. tuberculosis.engTBMDRXDRquinolonesfitnessMolecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALMycobacterium tuberculosis Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis classical and new drugs.pdfMycobacterium tuberculosis Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis classical and new drugs.pdfapplication/pdf357339https://repositorio.furg.br/bitstream/1/4307/1/Mycobacterium%20tuberculosis%20Molecular%20basis%20and%20mechanisms%20of%20drug%20resistance%20in%20Mycobacterium%20tuberculosis%20%20classical%20and%20new%20drugs.pdfb9d74ba293904e25632431580698bf2bMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/4307/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/43072014-01-17 15:26:18.548open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2014-01-17T17:26:18Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
title |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
spellingShingle |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs Silva, Pedro Eduardo Almeida da TB MDR XDR quinolones fitness |
title_short |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
title_full |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
title_fullStr |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
title_full_unstemmed |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
title_sort |
Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs |
author |
Silva, Pedro Eduardo Almeida da |
author_facet |
Silva, Pedro Eduardo Almeida da Palomino, Juan Carlos |
author_role |
author |
author2 |
Palomino, Juan Carlos |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Silva, Pedro Eduardo Almeida da Palomino, Juan Carlos |
dc.subject.por.fl_str_mv |
TB MDR XDR quinolones fitness |
topic |
TB MDR XDR quinolones fitness |
description |
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) TB have been described. After the discovery of several drugs with anti-TB activity, multidrug therapy became fundamental for control of the disease. Major advances in molecular biology and the availability of new information generated after sequencing the genome of Mycobacterium tuberculosis increased our knowledge of the mechanisms of resistance to the main anti-TB drugs. Better knowledge of the mechanisms of drug resistance in TB and the molecular mechanisms involved will help us to improve current techniques for rapid detection and will also stimulate the exploration of new targets for drug activity and drug development. This article presents an updated review of the mechanisms and molecular basis of drug resistance in M. tuberculosis. It also comments on the several gaps in our current knowledge of the molecular mechanisms of drug resistance to the main classical and new anti-TB drugs and briefly discusses some implications of the development of drug resistance and fitness, transmission and pathogenicity of M. tuberculosis. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-01-17T17:26:18Z |
dc.date.available.fl_str_mv |
2014-01-17T17:26:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Pedro Eduardo Almeida da; PALOMINO, Juan Carlos. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs . Journal of Antimicrobial Chemotherapy, v. 66, n. 7, p. 1417-1430, 2011. Disponível em: <http://jac.oxfordjournals.org/content/66/7/1417.full.pdf+html>. Acesso em: 23 dez. 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/4307 |
dc.identifier.issn.none.fl_str_mv |
0305-7453 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1093/jac/dkr173 |
identifier_str_mv |
SILVA, Pedro Eduardo Almeida da; PALOMINO, Juan Carlos. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs . Journal of Antimicrobial Chemotherapy, v. 66, n. 7, p. 1417-1430, 2011. Disponível em: <http://jac.oxfordjournals.org/content/66/7/1417.full.pdf+html>. Acesso em: 23 dez. 2013. 0305-7453 10.1093/jac/dkr173 |
url |
http://repositorio.furg.br/handle/1/4307 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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