Prevalence of hepatitis C virus among users attending a voluntary testing centre in Rio Grande, Southern Brazil: predictive factors and hepatitis C virus genotypes

• Autor(a) principal: Germano, Fabiana Nunes
• Data de Publicação: 2010
• Outros Autores: Santos, Cristina Araújo dos, Honscha, Gunther, Strasburg, Aline da Cruz, Gabbi, Bruno Smidt, Mendoza-Sassi, Raúl Andrés
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da FURG (RI FURG)
• Texto Completo: http://repositorio.furg.br/handle/1/7038
• topic: HCV; Genotype; Prevalence; Risk factors; Southern Brazil

Summary: We estimated the prevalence of hepatitis C (HCV) infection and associated risk factors in 750 individuals attendING at the voluntary counseling and Testing Center of Rio Grande (VCT/RG), in Southern Brazil, and identified viral genotypes. Demographic data and risk factors for HCV transmission were also collected and analysed. Anti-HCV-antibody-positive individuals were tested for HCV-RNA and genotyped by sequencing the 50 untranslated region of the viral genome. Prevalence estimates of anti-HCV and HCVRNA were 6% and 5.5%, respectively. We identified genotypes 1 (67%), 2 (2%) and 3 (31%); the latter was more prevalent than in other regions of Brazil. Anti-HCV prevalence in VCT/RG users was similar to previous reports. Age, previous blood transfusion, sexual orientation and injecting drug use were independent predictors of HCV infection. The presence of multiple risk factors was also associated with a higher risk for HCV infection. HCV genotype was not associated with any variable analysed in this study.