Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1242 |
Resumo: | Dyslipidemias are closely associated to the development of cardiovascular and cerebrovascular diseases, and therefore of great importance in public health. Many genes influence lipid levels, such as APOE and APOB. The present study aimed to investigate the effects of APOE gene alleles (rs7412: C>T and rs429358: T>C), and R3500Q mutation of APOB gene (rs5742904: G>A) in lipid levels in a South Brazilian cohort. 214 individuals were analyzed and the frequencies of APOE ε2, ε3 and ε4 alleles were found respectively as 9.25 ± 0.4625; 70.5 ± 3.525 and 20.25%± 1.401, while the frequency of R3500Q mutation of the APOB gene was 4.46 ± 1.00%. The ε4 allele was significantly more frequent in subjects with higher TC (Total Cholesterol) and LDL-C levels, while significantly higher frequency of the ε2 allele was found in individuals with higher HDL-C levels. The R3500Q mutation was suggested as a risk factor for higher TC levels, regardless gender and age (β = 21.326 ± 10377.78, p = 0.001). |
id |
GOE-1_658ad36b0c1172142750ba78385d1b27 |
---|---|
oai_identifier_str |
oai:ojs.bjihs.emnuvens.com.br:article/1242 |
network_acronym_str |
GOE-1 |
network_name_str |
Brazilian Journal of Implantology and Health Sciences |
repository_id_str |
|
spelling |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian CohortPolimorfismos de los genes APOE y APOB y dislipidemias en una cohorte del sur de BrasilPolymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian CohortDislipidemiasAPOEAPOBgenéticadyslipidemiasAPOEAPOBgeneticsDislipidemiasAPOEAPOBgenéticaDyslipidemias are closely associated to the development of cardiovascular and cerebrovascular diseases, and therefore of great importance in public health. Many genes influence lipid levels, such as APOE and APOB. The present study aimed to investigate the effects of APOE gene alleles (rs7412: C>T and rs429358: T>C), and R3500Q mutation of APOB gene (rs5742904: G>A) in lipid levels in a South Brazilian cohort. 214 individuals were analyzed and the frequencies of APOE ε2, ε3 and ε4 alleles were found respectively as 9.25 ± 0.4625; 70.5 ± 3.525 and 20.25%± 1.401, while the frequency of R3500Q mutation of the APOB gene was 4.46 ± 1.00%. The ε4 allele was significantly more frequent in subjects with higher TC (Total Cholesterol) and LDL-C levels, while significantly higher frequency of the ε2 allele was found in individuals with higher HDL-C levels. The R3500Q mutation was suggested as a risk factor for higher TC levels, regardless gender and age (β = 21.326 ± 10377.78, p = 0.001).Las dislipidemias están asociadas con el desarrollo de enfermedades cardiovasculares y cerebrovasculares y, por tanto, son de gran importancia en la salud pública. Muchos genes influyen en los niveles de lípidos, como APOE y APOB. El presente estudio tuvo como objetivo investigar los efectos de los alelos del gen APOE (rs7412: C>T y rs429358: T>C) y la mutación R3500Q del gen APOB (rs5742904: G>A) sobre los niveles de lípidos en una cohorte del sur de Brasil. Se analizaron 214 individuos y se encontró que las frecuencias de los alelos APOE ε2, ε3 y ε4 eran respectivamente 9,25 ± 0,4625; 70,5 ± 3,525 y 20,25% ± 1,401, mientras que la frecuencia de la mutación R3500Q del gen APOB fue de 4,46 ± 1,00%. El alelo ε4 fue significativamente más frecuente en individuos con niveles más altos de TC (colesterol total) y LDL-C, mientras que se encontró una frecuencia significativamente mayor del alelo ε2 en individuos con niveles más altos de HDL-C. La mutación R3500Q se sugirió como factor de riesgo para niveles más altos de CT, independientemente del sexo y la edad (β = 21,326 ± 10.377,78, p = 0,001).Dyslipidemias are closely associated to the development of cardiovascular and cerebrovascular diseases, and therefore of great importance in public health. Many genes influence lipid levels, such as APOE and APOB. The present study aimed to investigate the effects of APOE gene alleles (rs7412: C>T and rs429358: T>C), and R3500Q mutation of APOB gene (rs5742904: G>A) in lipid levels in a South Brazilian cohort. 214 individuals were analyzed and the frequencies of APOE ε2, ε3 and ε4 alleles were found respectively as 9.25 ± 0.4625; 70.5 ± 3.525 and 20.25%± 1.401, while the frequency of R3500Q mutation of the APOB gene was 4.46 ± 1.00%. The ε4 allele was significantly more frequent in subjects with higher TC (Total Cholesterol) and LDL-C levels, while significantly higher frequency of the ε2 allele was found in individuals with higher HDL-C levels. The R3500Q mutation was suggested as a risk factor for higher TC levels, regardless gender and age (β = 21.326 ± 10377.78, p = 0.001).Specialized Dentistry Group2024-01-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/124210.36557/2674-8169.2024v6n1p992-1012Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 992-1012Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 992-1012Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 992-10122674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1242/1427Copyright (c) 2024 Caroline Cardozo Gasparin, Luciane Viater Tureck, Lilian Pereira Ferrari, Ricardo Lehtonen Rodrigues de Souza, Lupe Furtado Allehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardozo Gasparin, CarolineViater Tureck, LucianePereira Ferrari, LilianLehtonen Rodrigues de Souza, RicardoFurtado Alle, Lupe2024-01-13T20:42:13Zoai:ojs.bjihs.emnuvens.com.br:article/1242Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-01-13T20:42:13Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort Polimorfismos de los genes APOE y APOB y dislipidemias en una cohorte del sur de Brasil Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
title |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
spellingShingle |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort Cardozo Gasparin, Caroline Dislipidemias APOE APOB genética dyslipidemias APOE APOB genetics Dislipidemias APOE APOB genética |
title_short |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
title_full |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
title_fullStr |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
title_full_unstemmed |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
title_sort |
Polymorphisms of APOE and APOB genes and dyslipidemias in a South Brazilian Cohort |
author |
Cardozo Gasparin, Caroline |
author_facet |
Cardozo Gasparin, Caroline Viater Tureck, Luciane Pereira Ferrari, Lilian Lehtonen Rodrigues de Souza, Ricardo Furtado Alle, Lupe |
author_role |
author |
author2 |
Viater Tureck, Luciane Pereira Ferrari, Lilian Lehtonen Rodrigues de Souza, Ricardo Furtado Alle, Lupe |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cardozo Gasparin, Caroline Viater Tureck, Luciane Pereira Ferrari, Lilian Lehtonen Rodrigues de Souza, Ricardo Furtado Alle, Lupe |
dc.subject.por.fl_str_mv |
Dislipidemias APOE APOB genética dyslipidemias APOE APOB genetics Dislipidemias APOE APOB genética |
topic |
Dislipidemias APOE APOB genética dyslipidemias APOE APOB genetics Dislipidemias APOE APOB genética |
description |
Dyslipidemias are closely associated to the development of cardiovascular and cerebrovascular diseases, and therefore of great importance in public health. Many genes influence lipid levels, such as APOE and APOB. The present study aimed to investigate the effects of APOE gene alleles (rs7412: C>T and rs429358: T>C), and R3500Q mutation of APOB gene (rs5742904: G>A) in lipid levels in a South Brazilian cohort. 214 individuals were analyzed and the frequencies of APOE ε2, ε3 and ε4 alleles were found respectively as 9.25 ± 0.4625; 70.5 ± 3.525 and 20.25%± 1.401, while the frequency of R3500Q mutation of the APOB gene was 4.46 ± 1.00%. The ε4 allele was significantly more frequent in subjects with higher TC (Total Cholesterol) and LDL-C levels, while significantly higher frequency of the ε2 allele was found in individuals with higher HDL-C levels. The R3500Q mutation was suggested as a risk factor for higher TC levels, regardless gender and age (β = 21.326 ± 10377.78, p = 0.001). |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1242 10.36557/2674-8169.2024v6n1p992-1012 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1242 |
identifier_str_mv |
10.36557/2674-8169.2024v6n1p992-1012 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1242/1427 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 992-1012 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 992-1012 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 992-1012 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798443553816576 |