Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1328 |
Resumo: | Ulcerative colitis belongs to the group of inflammatory bowel diseases, which represent pathologies influenced by genetic and environmental factors, resulting in an immunological imbalance followed by tissue damage. These environmental provocations trigger inflammatory processes restricted to the mucous layer of the colon, especially in the rectum, which can spread to other regions. The main therapeutic interventions are surgical management and the use of medications, such as Vedolizumab. This article aims to scan the current medical literature on the treatment of Ulcerative Colitis using Vedolizumab. This is an integrative review of the literature, using the Pubmed and Virtual Health Library (VHL) databases, by crossing the descriptors “vedolizumab”, “therapeutic” and “ulcerative colitis”, with the Boolean operator “AND” . The searches result in 509 articles, with those that coincide with the topic in focus being selected and the rest excluded due to less coverage and evasion of the topic. Among the inclusion criteria, articles were included in Portuguese, English and Spanish, especially from the last 5 years, resulting in 7 articles. The drug Vedolizumab has specific immunosuppressive properties for the intestine, demonstrating indication for the treatment of moderate to severe ulcerative colitis. This medication acts through its binding to the α4β7 integrin expressed in intestinal T lymphocytes, inhibiting the inflammatory process and reducing the patient's symptoms. Thus, therapeutics measures using this drug, aimed at patients with ulcerative colitis, appear to be safe and effective. |
id |
GOE-1_b6de9e8746111be76de80055e39d5efb |
---|---|
oai_identifier_str |
oai:ojs.bjihs.emnuvens.com.br:article/1328 |
network_acronym_str |
GOE-1 |
network_name_str |
Brazilian Journal of Implantology and Health Sciences |
repository_id_str |
|
spelling |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature ReviewSeguridad de vedolizumab en el tratamiento de la colitis ulcerosa: una revisión de la literatura.A Segurança do Vedolizumabe no tratamento da Retocolite Ulcerativa: Uma revisão de literatura. Colite Ulcerativa; Tratamento; VedolizumabUlcerative Colitis; Ulcerative Colitesreatment; Vedolizumabe.Colitis ulcerosa; Tratamiento; vedolizumabUlcerative colitis belongs to the group of inflammatory bowel diseases, which represent pathologies influenced by genetic and environmental factors, resulting in an immunological imbalance followed by tissue damage. These environmental provocations trigger inflammatory processes restricted to the mucous layer of the colon, especially in the rectum, which can spread to other regions. The main therapeutic interventions are surgical management and the use of medications, such as Vedolizumab. This article aims to scan the current medical literature on the treatment of Ulcerative Colitis using Vedolizumab. This is an integrative review of the literature, using the Pubmed and Virtual Health Library (VHL) databases, by crossing the descriptors “vedolizumab”, “therapeutic” and “ulcerative colitis”, with the Boolean operator “AND” . The searches result in 509 articles, with those that coincide with the topic in focus being selected and the rest excluded due to less coverage and evasion of the topic. Among the inclusion criteria, articles were included in Portuguese, English and Spanish, especially from the last 5 years, resulting in 7 articles. The drug Vedolizumab has specific immunosuppressive properties for the intestine, demonstrating indication for the treatment of moderate to severe ulcerative colitis. This medication acts through its binding to the α4β7 integrin expressed in intestinal T lymphocytes, inhibiting the inflammatory process and reducing the patient's symptoms. Thus, therapeutics measures using this drug, aimed at patients with ulcerative colitis, appear to be safe and effective.La colitis ulcerosa pertenece al grupo de enfermedades inflamatorias intestinales, que representan patologías influenciadas por factores genéticos y ambientales, que resultan en un desequilibrio inmunológico seguido de daño tisular. Estas provocaciones ambientales desencadenan procesos inflamatorios restringidos a la capa mucosa del colon, especialmente en el recto, que pueden extenderse a otras regiones. Las principales intervenciones terapéuticas son el manejo quirúrgico y el uso de medicamentos, como el Vedolizumab. Este artículo tiene como objetivo explorar la literatura médica actual sobre el tratamiento de la colitis ulcerosa con vedolizumab. Se trata de una revisión integradora de la literatura, utilizando las bases de datos Pubmed y Biblioteca Virtual en Salud (BVS), mediante el cruce de los descriptores “vedolizumab”, “terapéutico” y “colitis ulcerosa”, con el operador booleano “Y”. Las búsquedas dan como resultado 509 artículos, siendo seleccionados los que coinciden con el tema en cuestión y excluidos el resto por menor cobertura y evasión del tema. Entre los criterios de inclusión se incluyeron artículos en portugués, inglés y español, especialmente de los últimos 5 años, resultando 6 artículos. El fármaco Vedolizumab tiene propiedades inmunosupresoras específicas para el intestino, lo que demuestra indicación para el tratamiento de la colitis ulcerosa de moderada a grave. Este medicamento actúa mediante su unión a la integrina α4β7 expresada en los linfocitos T intestinales, inhibiendo el proceso inflamatorio y reduciendo los síntomas del paciente. Por tanto, las medidas terapéuticas que utilizan este fármaco, dirigidas a pacientes con colitis ulcerosa, parecen seguras y eficaces. A colite ulcerativa pertence ao grupo de doenças inflamatórias intestinais, que representam patologias influenciadas por fatores genéticos e ambientais, resultando em um desequilíbrio imunológico seguido de lesões teciduais. Essas provocações ambientais desencadeiam processos inflamatórios restritos à camada mucosa do cólon, em especial no reto, podendo avançar para outras regiões. As principais intervenções terapêuticas são o manejo cirúrgico e o uso de medicamentos, como o Vedolizumabe. Este artigo tem por objetivo realizar uma varredura da literatura médica vigente sobre o tratamento da Retocolite Ulcerativa utilizando o Vedolizumabe. Trata-se de uma revisão integrativa da literatura, utilizando as bases de dados Pubmed e Biblioteca Virtual de Saúde (BVS), por meio do cruzamento dos descritores “vedolizumab”, “therapeutic” e “ulcerative colitis”, com operador booleano “AND”. As buscas resultam em 509 artigos, sendo selecionados os que coincidem com a temática em foco e excluídos o restante pela menor abrangência e fuga do tema. Dentre os critérios de inclusão, foram inseridos artigos em português, inglês e espanhol, em especial dos últimos 5 anos, resultando em 6 artigos. O fármaco Vedolizumabe possui propriedades imunossupressoras específicas ao intestino, demonstrando indicação para o tratamento da colite ulcerativa moderada a grave. Esse medicamento, apresenta ação através da sua ligação à integrina α4β7 expressa em linfócitos T intestinais, inibindo o processo inflamatório e diminuindo a sintomatologia do paciente. Assim, medidas terapêuticas por meio desse fármaco, destinada a pacientes com retocolite ulcerativa, mostra-se segura e eficaz.Specialized Dentistry Group2024-01-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://bjihs.emnuvens.com.br/bjihs/article/view/132810.36557/2674-8169.2024v6n1p1918-1926Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 1918-1926Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 1918-1926Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 1918-19262674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1328/1514Copyright (c) 2024 Karine Nava Jaeger, Maria Eduarda Mintzfels Branco, Ileana Simone de Oliveira Moura, Lorenzo Gabriel de Azevedo Viera, Jhoni Michael de Oliveira Cardoso, Caroline Bezerra Trajano dos Santos, Carlos Galvão Branco Araújo , Gabriela Priscila de Lima Silva, Cássia Nava Jaeger, Viviane Kelly de Souza Moura , Ágape Meira Santos , João Marcos Barcelos Sales , Flávia Larisse Rabelo https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessJaeger, Karine Nava Branco, Maria Eduarda Mintzfels Moura, Ileana Simone de OliveiraViera, Lorenzo Gabriel de AzevedoCardoso, Jhoni Michael de OliveiraSantos, Caroline Bezerra Trajano dosAraújo , Carlos Galvão BrancoSilva, Gabriela Priscila de Lima Jaeger, Cássia NavaMoura , Viviane Kelly de SouzaSantos , Ágape Meira Sales , João Marcos BarcelosRabelo , Flávia Larisse2024-01-26T17:34:13Zoai:ojs.bjihs.emnuvens.com.br:article/1328Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-01-26T17:34:13Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review Seguridad de vedolizumab en el tratamiento de la colitis ulcerosa: una revisión de la literatura. A Segurança do Vedolizumabe no tratamento da Retocolite Ulcerativa: Uma revisão de literatura. |
title |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
spellingShingle |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review Jaeger, Karine Nava Colite Ulcerativa; Tratamento; Vedolizumab Ulcerative Colitis; Ulcerative Colitesreatment; Vedolizumabe. Colitis ulcerosa; Tratamiento; vedolizumab |
title_short |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
title_full |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
title_fullStr |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
title_full_unstemmed |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
title_sort |
Vedolizumab Safety in Treatment of Ulcerative Colitis: a Literature Review |
author |
Jaeger, Karine Nava |
author_facet |
Jaeger, Karine Nava Branco, Maria Eduarda Mintzfels Moura, Ileana Simone de Oliveira Viera, Lorenzo Gabriel de Azevedo Cardoso, Jhoni Michael de Oliveira Santos, Caroline Bezerra Trajano dos Araújo , Carlos Galvão Branco Silva, Gabriela Priscila de Lima Jaeger, Cássia Nava Moura , Viviane Kelly de Souza Santos , Ágape Meira Sales , João Marcos Barcelos Rabelo , Flávia Larisse |
author_role |
author |
author2 |
Branco, Maria Eduarda Mintzfels Moura, Ileana Simone de Oliveira Viera, Lorenzo Gabriel de Azevedo Cardoso, Jhoni Michael de Oliveira Santos, Caroline Bezerra Trajano dos Araújo , Carlos Galvão Branco Silva, Gabriela Priscila de Lima Jaeger, Cássia Nava Moura , Viviane Kelly de Souza Santos , Ágape Meira Sales , João Marcos Barcelos Rabelo , Flávia Larisse |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jaeger, Karine Nava Branco, Maria Eduarda Mintzfels Moura, Ileana Simone de Oliveira Viera, Lorenzo Gabriel de Azevedo Cardoso, Jhoni Michael de Oliveira Santos, Caroline Bezerra Trajano dos Araújo , Carlos Galvão Branco Silva, Gabriela Priscila de Lima Jaeger, Cássia Nava Moura , Viviane Kelly de Souza Santos , Ágape Meira Sales , João Marcos Barcelos Rabelo , Flávia Larisse |
dc.subject.por.fl_str_mv |
Colite Ulcerativa; Tratamento; Vedolizumab Ulcerative Colitis; Ulcerative Colitesreatment; Vedolizumabe. Colitis ulcerosa; Tratamiento; vedolizumab |
topic |
Colite Ulcerativa; Tratamento; Vedolizumab Ulcerative Colitis; Ulcerative Colitesreatment; Vedolizumabe. Colitis ulcerosa; Tratamiento; vedolizumab |
description |
Ulcerative colitis belongs to the group of inflammatory bowel diseases, which represent pathologies influenced by genetic and environmental factors, resulting in an immunological imbalance followed by tissue damage. These environmental provocations trigger inflammatory processes restricted to the mucous layer of the colon, especially in the rectum, which can spread to other regions. The main therapeutic interventions are surgical management and the use of medications, such as Vedolizumab. This article aims to scan the current medical literature on the treatment of Ulcerative Colitis using Vedolizumab. This is an integrative review of the literature, using the Pubmed and Virtual Health Library (VHL) databases, by crossing the descriptors “vedolizumab”, “therapeutic” and “ulcerative colitis”, with the Boolean operator “AND” . The searches result in 509 articles, with those that coincide with the topic in focus being selected and the rest excluded due to less coverage and evasion of the topic. Among the inclusion criteria, articles were included in Portuguese, English and Spanish, especially from the last 5 years, resulting in 7 articles. The drug Vedolizumab has specific immunosuppressive properties for the intestine, demonstrating indication for the treatment of moderate to severe ulcerative colitis. This medication acts through its binding to the α4β7 integrin expressed in intestinal T lymphocytes, inhibiting the inflammatory process and reducing the patient's symptoms. Thus, therapeutics measures using this drug, aimed at patients with ulcerative colitis, appear to be safe and effective. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1328 10.36557/2674-8169.2024v6n1p1918-1926 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1328 |
identifier_str_mv |
10.36557/2674-8169.2024v6n1p1918-1926 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1328/1514 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 1918-1926 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 1918-1926 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 1918-1926 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798443768774656 |