Clinical Management of Hypertrophic Cardiomyopathy: Pharmacological Treatment and Surgical Interventions

• Autor(a) principal: Leal Silva Marim , Eloísa
• Data de Publicação: 2024
• Outros Autores: de Andrade Gomes, Amanda, Laurito Batista, Luana, Fonseca Sampaio, Andressa, de Assis Carnelós, Gabriel, Gontijo Perez de Queiroz, André, Felipe Ayres Furtado, Luiz, Longhitano Neto, Izaias, Milhomem Martins , Lethycia, Zopé Sartório Brum , Allexia, Januzzi Resende, Leticia
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1448
• topic: Cardiomiopatia Hipertrófica; Tratamento Farmacológico; Intervenções Cirúrgicas.; Hypertrophic Cardiomyopathy; Pharmacological Treatment; Surgical Interventions.

This study investigates emerging strategies in the clinical management of Hypertrophic Cardiomyopathy (HCM), adopting an integrative and innovative approach. Initially, advancements in pharmacological therapies are highlighted, focusing on promising agents for treatment and specific modulation that have demonstrated efficacy in preserving cardiac function and reducing disease progression. Beyond pharmacological approaches, the analysis extends to consider interventions exploring the underlying mechanisms of HCM. The identification of molecular targets and emerging biological pathways emphasizes the importance of understanding the disease's pathophysiology for the development of more targeted therapies. Another focal point addresses complementary therapies, such as optimizing surgical strategies and innovative drug delivery methods to enhance efficacy and minimize adverse effects. The analysis includes discussions on advanced surgical techniques and minimally invasive therapeutic approaches, representing significant advances in the pursuit of more effective and well-tolerated treatments. Simultaneously, therapies aiming not only at symptom relief but also at the preservation and improvement of compromised cardiac function are considered. This involves exploring regenerative approaches, such as cellular therapies and growth factors, highlighting their promising contribution to restoring cardiac health. In addition to therapeutic innovations, this work underscores the need for a comprehensive understanding of HCM, including genetic, metabolic, and environmental factors influencing individual responses to proposed therapies. The emphasis on personalized interventions underscores the complexity of the disease and the importance of considering individual patient characteristics. In conclusion, the study emphasizes the importance of a multidisciplinary approach, integrating different therapeutic modalities to optimize outcomes in HCM treatment. The combination of innovative pharmacological approaches, advanced surgical strategies, and regenerative therapies emerges as a promising perspective to comprehensively and effectively address this cardiac challenge.