New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de gastroenterologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032017000100051 |
Resumo: | ABSTRACT BACKGROUND Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. OBJECTIVE To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. METHODS Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey's classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). RESULTS Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. CONCLUSION The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients. |
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Arquivos de gastroenterologia (Online) |
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New index for the diagnosis of liver fibrosis in Schistosomiasis mansoniSchistosomiasis mansoniFibrosisROC curve analysisABSTRACT BACKGROUND Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. OBJECTIVE To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. METHODS Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey's classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). RESULTS Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. CONCLUSION The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032017000100051Arquivos de Gastroenterologia v.54 n.1 2017reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/s0004-2803.2017v54n1-10info:eu-repo/semantics/openAccessBARRETO,Ana Virgínia Matos SáALECRIM,Vinícius MartinsMEDEIROS,Tibério Batista deDOMINGUES,Ana Lúcia CoutinhoLOPES,Edmundo PessoaMARTINS,João Roberto MacielNADER,Helena BoncianiDINIZ,George Tadeu NunesMONTENEGRO,Silvia Maria LucenaMORAIS,Clarice Neuenschwander Lins deeng2017-05-24T00:00:00Zoai:scielo:S0004-28032017000100051Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2017-05-24T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse |
dc.title.none.fl_str_mv |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
title |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
spellingShingle |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni BARRETO,Ana Virgínia Matos Sá Schistosomiasis mansoni Fibrosis ROC curve analysis |
title_short |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
title_full |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
title_fullStr |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
title_full_unstemmed |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
title_sort |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
author |
BARRETO,Ana Virgínia Matos Sá |
author_facet |
BARRETO,Ana Virgínia Matos Sá ALECRIM,Vinícius Martins MEDEIROS,Tibério Batista de DOMINGUES,Ana Lúcia Coutinho LOPES,Edmundo Pessoa MARTINS,João Roberto Maciel NADER,Helena Bonciani DINIZ,George Tadeu Nunes MONTENEGRO,Silvia Maria Lucena MORAIS,Clarice Neuenschwander Lins de |
author_role |
author |
author2 |
ALECRIM,Vinícius Martins MEDEIROS,Tibério Batista de DOMINGUES,Ana Lúcia Coutinho LOPES,Edmundo Pessoa MARTINS,João Roberto Maciel NADER,Helena Bonciani DINIZ,George Tadeu Nunes MONTENEGRO,Silvia Maria Lucena MORAIS,Clarice Neuenschwander Lins de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
BARRETO,Ana Virgínia Matos Sá ALECRIM,Vinícius Martins MEDEIROS,Tibério Batista de DOMINGUES,Ana Lúcia Coutinho LOPES,Edmundo Pessoa MARTINS,João Roberto Maciel NADER,Helena Bonciani DINIZ,George Tadeu Nunes MONTENEGRO,Silvia Maria Lucena MORAIS,Clarice Neuenschwander Lins de |
dc.subject.por.fl_str_mv |
Schistosomiasis mansoni Fibrosis ROC curve analysis |
topic |
Schistosomiasis mansoni Fibrosis ROC curve analysis |
description |
ABSTRACT BACKGROUND Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. OBJECTIVE To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. METHODS Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey's classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). RESULTS Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. CONCLUSION The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032017000100051 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032017000100051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0004-2803.2017v54n1-10 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. |
publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. |
dc.source.none.fl_str_mv |
Arquivos de Gastroenterologia v.54 n.1 2017 reponame:Arquivos de gastroenterologia (Online) instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia instacron:IBEPEGE |
instname_str |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia |
instacron_str |
IBEPEGE |
institution |
IBEPEGE |
reponame_str |
Arquivos de gastroenterologia (Online) |
collection |
Arquivos de gastroenterologia (Online) |
repository.name.fl_str_mv |
Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia |
repository.mail.fl_str_mv |
||secretariaarqgastr@hospitaligesp.com.br |
_version_ |
1754193348099309568 |