Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin

Detalhes bibliográficos
Autor(a) principal: Sarges, Flávio N
Data de Publicação: 2017
Outros Autores: Cascaes, Márcia Moraes, Moraes, Lienne S, Guilhon, Giselle Maria Skelding Pinheiro, Silva, Edilene O, Zoghbi, Maria das Graças B, Andrade, Eloisa Helena de Aguiar, Rodrigues, Ana Paula D, Costa, Brenda F, Figueiredo, Rayssa N. M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/2923
Resumo: The chemical study of Eugenia protenta McVaugh extracts performed by classical and high-performance liquid chromatography techniques and spectral methods has led to the identification of known triterpenoids, flavonoids and an acetophenone derivative (dimethylxanthoxylin). The effect of dimethylxanthoxylin on Leishmania (Leishmania) amazonensis was evaluated against the promastigotes forms after 96 h of treatment. Dimethylxanthoxylin reduced 57 and 59% of the promastigotes growth when treated with 50 and 100 μg/mL solutions, respectively (IC50 117.35 μg/mL or 52.3 μM). Cytotoxicity experiments using MTT assays showed that this substance did not promote cell death after 24 h of treatment. Dimethylxanthoxylin was active on the promastigotes and could be a promising agent for treating leishmaniasis.
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spelling Sarges, Flávio NCascaes, Márcia MoraesMoraes, Lienne SGuilhon, Giselle Maria Skelding PinheiroSilva, Edilene OZoghbi, Maria das Graças BAndrade, Eloisa Helena de AguiarRodrigues, Ana Paula DCosta, Brenda FFigueiredo, Rayssa N. M2018-02-06T13:50:42Z2018-02-06T13:50:42Z2017SARGES, Flávio N. et al. Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin. Natural Product Research, v. 31, p. 1-5, Dec. 2017.1478-6419https://patua.iec.gov.br/handle/iec/292310.1080/14786419.2017.1410804The chemical study of Eugenia protenta McVaugh extracts performed by classical and high-performance liquid chromatography techniques and spectral methods has led to the identification of known triterpenoids, flavonoids and an acetophenone derivative (dimethylxanthoxylin). The effect of dimethylxanthoxylin on Leishmania (Leishmania) amazonensis was evaluated against the promastigotes forms after 96 h of treatment. Dimethylxanthoxylin reduced 57 and 59% of the promastigotes growth when treated with 50 and 100 μg/mL solutions, respectively (IC50 117.35 μg/mL or 52.3 μM). Cytotoxicity experiments using MTT assays showed that this substance did not promote cell death after 24 h of treatment. Dimethylxanthoxylin was active on the promastigotes and could be a promising agent for treating leishmaniasis.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil / Museu Paraense Emílio Goeldi. Coordenação de Botânica. Programa de Capacitação Institucional. Belém, PA, Brazil.Universidade Federal do Pará. Laboratório de Protozoologia e Biologia Estrutural. Belém, PA, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Ciência e Tecnologia em Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil.Universidade Federal do Pará. Laboratório de Protozoologia e Biologia Estrutural. Belém, PA, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Ciência e Tecnologia em Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brazil.Museu Paraense Emílio Goeldi. Belém, PA, Brazil.Universidade Federal do Pará. Instituto de Ciências Exatas e Naturais. Programa de Pós-Graduação em Química. Belém, PA, Brazil / Museu Paraense Emílio Goeldi. Belém, PA, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Ciência e Tecnologia em Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Belém, PA, Brasil.engTaylor & FrancisChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFitoterapiaExtratos Vegetais / químicaCromatografia Líquida / métodosDimethylxanthoxylin / químicaFlavonoidesPlantas MedicinaisLeishmanioseinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/7c22f5c0-f17b-4ea7-85d1-f3a2ed23e579/download52f1732ea66fbd1123abe39f5373b797MD52ORIGINALChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdfChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/dcabebc1-cbc3-487b-bea8-8d0299d38635/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD53TEXTChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdf.txtChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/1a3bcb18-7b55-4252-9730-8a09070f741d/downloade1c06d85ae7b8b032bef47e42e4c08f9MD56THUMBNAILChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdf.jpgChemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/aa60b4b2-d537-4b77-aa5c-4d53d774adbc/download71859d578212107f7f8c49a4ce09d9eeMD57iec/29232023-05-17 18:01:18.955oai:patua.iec.gov.br:iec/2923https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-05-17T18:01:18Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
title Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
spellingShingle Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
Sarges, Flávio N
Fitoterapia
Extratos Vegetais / química
Cromatografia Líquida / métodos
Dimethylxanthoxylin / química
Flavonoides
Plantas Medicinais
Leishmaniose
title_short Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
title_full Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
title_fullStr Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
title_full_unstemmed Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
title_sort Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin
author Sarges, Flávio N
author_facet Sarges, Flávio N
Cascaes, Márcia Moraes
Moraes, Lienne S
Guilhon, Giselle Maria Skelding Pinheiro
Silva, Edilene O
Zoghbi, Maria das Graças B
Andrade, Eloisa Helena de Aguiar
Rodrigues, Ana Paula D
Costa, Brenda F
Figueiredo, Rayssa N. M
author_role author
author2 Cascaes, Márcia Moraes
Moraes, Lienne S
Guilhon, Giselle Maria Skelding Pinheiro
Silva, Edilene O
Zoghbi, Maria das Graças B
Andrade, Eloisa Helena de Aguiar
Rodrigues, Ana Paula D
Costa, Brenda F
Figueiredo, Rayssa N. M
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sarges, Flávio N
Cascaes, Márcia Moraes
Moraes, Lienne S
Guilhon, Giselle Maria Skelding Pinheiro
Silva, Edilene O
Zoghbi, Maria das Graças B
Andrade, Eloisa Helena de Aguiar
Rodrigues, Ana Paula D
Costa, Brenda F
Figueiredo, Rayssa N. M
dc.subject.decsPrimary.pt_BR.fl_str_mv Fitoterapia
Extratos Vegetais / química
Cromatografia Líquida / métodos
Dimethylxanthoxylin / química
Flavonoides
Plantas Medicinais
Leishmaniose
topic Fitoterapia
Extratos Vegetais / química
Cromatografia Líquida / métodos
Dimethylxanthoxylin / química
Flavonoides
Plantas Medicinais
Leishmaniose
description The chemical study of Eugenia protenta McVaugh extracts performed by classical and high-performance liquid chromatography techniques and spectral methods has led to the identification of known triterpenoids, flavonoids and an acetophenone derivative (dimethylxanthoxylin). The effect of dimethylxanthoxylin on Leishmania (Leishmania) amazonensis was evaluated against the promastigotes forms after 96 h of treatment. Dimethylxanthoxylin reduced 57 and 59% of the promastigotes growth when treated with 50 and 100 μg/mL solutions, respectively (IC50 117.35 μg/mL or 52.3 μM). Cytotoxicity experiments using MTT assays showed that this substance did not promote cell death after 24 h of treatment. Dimethylxanthoxylin was active on the promastigotes and could be a promising agent for treating leishmaniasis.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-06T13:50:42Z
dc.date.available.fl_str_mv 2018-02-06T13:50:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SARGES, Flávio N. et al. Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin. Natural Product Research, v. 31, p. 1-5, Dec. 2017.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/2923
dc.identifier.issn.-.fl_str_mv 1478-6419
dc.identifier.doi.-.fl_str_mv 10.1080/14786419.2017.1410804
identifier_str_mv SARGES, Flávio N. et al. Chemical characterisation of the constituents of Eugenia protenta McVaugh and leishmanicidal activity of dimethylxanthoxylin. Natural Product Research, v. 31, p. 1-5, Dec. 2017.
1478-6419
10.1080/14786419.2017.1410804
url https://patua.iec.gov.br/handle/iec/2923
dc.language.iso.fl_str_mv eng
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publisher.none.fl_str_mv Taylor & Francis
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