Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
| Texto Completo: | https://patua.iec.gov.br/handle/iec/379 |
Resumo: | We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the PlateliaTM dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the PlateliaTM dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses. |
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Sea, Vanessa Ramos FariaCruz, Ana Cecília RibeiroGurgel, Ricardo QNunes, Bruno Tardelli DinizSilva, Eliana Vieira Pinto daDolabella, Silvio SSantos, Roseli La Corte dos2016-01-26T11:22:40Z2016-01-26T11:22:40Z2013SEA, Vanessa Ramos Faria et al. Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs. PLoS ONE, v. 8, n. 5, p. 1-3, May 2013https://patua.iec.gov.br/handle/iec/37910.1371/journal.pone.0064056We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the PlateliaTM dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the PlateliaTM dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.Universidade Federal de Sergipe. Aracaju, SE, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidade Federal de Sergipe. Aracaju, SE, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Universidade Federal de Sergipe. Aracaju, SE, Brazil.Universidade Federal de Sergipe. 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| dc.title.pt_BR.fl_str_mv |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| title |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| spellingShingle |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs Sea, Vanessa Ramos Faria Dengue / diagnóstico Aedes Vigilância da População Aracaju (SE) |
| title_short |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| title_full |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| title_fullStr |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| title_full_unstemmed |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| title_sort |
Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs |
| author |
Sea, Vanessa Ramos Faria |
| author_facet |
Sea, Vanessa Ramos Faria Cruz, Ana Cecília Ribeiro Gurgel, Ricardo Q Nunes, Bruno Tardelli Diniz Silva, Eliana Vieira Pinto da Dolabella, Silvio S Santos, Roseli La Corte dos |
| author_role |
author |
| author2 |
Cruz, Ana Cecília Ribeiro Gurgel, Ricardo Q Nunes, Bruno Tardelli Diniz Silva, Eliana Vieira Pinto da Dolabella, Silvio S Santos, Roseli La Corte dos |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Sea, Vanessa Ramos Faria Cruz, Ana Cecília Ribeiro Gurgel, Ricardo Q Nunes, Bruno Tardelli Diniz Silva, Eliana Vieira Pinto da Dolabella, Silvio S Santos, Roseli La Corte dos |
| dc.subject.decsPrimary.pt_BR.fl_str_mv |
Dengue / diagnóstico Aedes Vigilância da População Aracaju (SE) |
| topic |
Dengue / diagnóstico Aedes Vigilância da População Aracaju (SE) |
| description |
We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the PlateliaTM dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the PlateliaTM dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses. |
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2013 |
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2013 |
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2016-01-26T11:22:40Z |
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2016-01-26T11:22:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SEA, Vanessa Ramos Faria et al. Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs. PLoS ONE, v. 8, n. 5, p. 1-3, May 2013 |
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https://patua.iec.gov.br/handle/iec/379 |
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10.1371/journal.pone.0064056 |
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SEA, Vanessa Ramos Faria et al. Underreporting of dengue-4 in Brazil due to low sensitivity of the NS1 ag test in routine control programs. PLoS ONE, v. 8, n. 5, p. 1-3, May 2013 10.1371/journal.pone.0064056 |
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