Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Belém, Pará, Amazon region of Brazil

• Autor(a) principal: Torres, Maria K. S
• Data de Publicação: 2020
• Outros Autores: Avelino, Maria E. S, Irias, Susan F, Barbosa, Mike S, Pereira, Danilo L. A, Lima, Ana B. F, Lemos, Poliana da Silva, Lima, Clayton Pereira Silva de, Oliveira, Renato R. M, Frânces, Regiane S. K, Vianez Júnior, João Lídio da Silva Gonçalves, Machado, Luiz Fernando Almeida
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/4053
• topic: HIV-1 / patogenicidade; Terapia Antirretroviral de Alta Atividade; Infecções por HIV; Síndrome de Imunodeficiência Adquirida; Integrase de HIV; Integrases

We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Belém, Pará, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and sequenced. Genotypic analyses revealed the absence of major resistance-associated mutations to integrase but minor polymorphic mutations were present in 44.1% of patients and M50I polymorphism was the more prevalent.