Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3577 |
Resumo: | Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. vivax merozoite surface protein 1 (MSP119), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response. |
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Cerávolo, Isabela PBruña-Romero, OscarBraga, Érika MFontes, Cór Jésus FernandesBrito, Cristiana F. ASouza, José Maria deKrettli, Antoniana UAdams, John HCarvalho, Luzia H2019-01-23T17:33:25Z2019-01-23T17:33:25Z2005CERÁVOLO, Isabela P. et al. Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon. American Journal of Tropical Medicine and Hygiene, v. 72, n. 6, p. 675-681, 2005. DOI: https://doi.org/10.4269/ajtmh.2005.72.675. Disponível em: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.533.3398&rep=rep1&type=pdf.0002-9637https://patua.iec.gov.br/handle/iec/357710.4269/ajtmh.2005.72.675Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. vivax merozoite surface protein 1 (MSP119), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response.This work was supported by the UNICEF/UNDP/ Word Bank/WHO Special Program for Research and Training in Tropical Diseases (TDR), the Brazilian National Research Council (CNPq), and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil.Universidade Federal de Mato Grosso. Hospital Júlio Muller. Cuiabá, MT, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil.University of Notre Dame. Department of Biological Sciences. Notre Dame, IN.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil.engAmerican Society of Tropical Medicine and HygieneAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePlasmodium vivax / genéticaImunoglobulina GProteína 1 de Superfície de Merozoito / imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdfAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdfapplication/pdf316921https://patua.iec.gov.br/bitstreams/b5f034ca-a0f0-4cd4-9672-a674041fd244/download1292c39a75b63d7c326ba667088b7f47MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/548330da-13e1-47bf-8bb6-883a29b8e14f/download11832eea31b16df8613079d742d61793MD52TEXTAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdf.txtAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdf.txtExtracted texttext/plain35665https://patua.iec.gov.br/bitstreams/43630ea5-5e7a-4609-a548-ff67ad8d28a5/downloaded81d771470df37bba0ae82d9d08ee1dMD55THUMBNAILAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdf.jpgAnti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon.pdf.jpgGenerated Thumbnailimage/jpeg5876https://patua.iec.gov.br/bitstreams/e3841edc-62f9-4bcd-8bd6-fc630001b9fe/download00d6dbfdc340dea0cd6195b5e83087e4MD56iec/35772022-10-20 22:32:18.204oai:patua.iec.gov.br:iec/3577https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:32:18Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
title |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
spellingShingle |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon Cerávolo, Isabela P Plasmodium vivax / genética Imunoglobulina G Proteína 1 de Superfície de Merozoito / imunologia |
title_short |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
title_full |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
title_fullStr |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
title_full_unstemmed |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
title_sort |
Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon |
author |
Cerávolo, Isabela P |
author_facet |
Cerávolo, Isabela P Bruña-Romero, Oscar Braga, Érika M Fontes, Cór Jésus Fernandes Brito, Cristiana F. A Souza, José Maria de Krettli, Antoniana U Adams, John H Carvalho, Luzia H |
author_role |
author |
author2 |
Bruña-Romero, Oscar Braga, Érika M Fontes, Cór Jésus Fernandes Brito, Cristiana F. A Souza, José Maria de Krettli, Antoniana U Adams, John H Carvalho, Luzia H |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cerávolo, Isabela P Bruña-Romero, Oscar Braga, Érika M Fontes, Cór Jésus Fernandes Brito, Cristiana F. A Souza, José Maria de Krettli, Antoniana U Adams, John H Carvalho, Luzia H |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Plasmodium vivax / genética Imunoglobulina G Proteína 1 de Superfície de Merozoito / imunologia |
topic |
Plasmodium vivax / genética Imunoglobulina G Proteína 1 de Superfície de Merozoito / imunologia |
description |
Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. vivax merozoite surface protein 1 (MSP119), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2019-01-23T17:33:25Z |
dc.date.available.fl_str_mv |
2019-01-23T17:33:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CERÁVOLO, Isabela P. et al. Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon. American Journal of Tropical Medicine and Hygiene, v. 72, n. 6, p. 675-681, 2005. DOI: https://doi.org/10.4269/ajtmh.2005.72.675. Disponível em: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.533.3398&rep=rep1&type=pdf. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3577 |
dc.identifier.issn.-.fl_str_mv |
0002-9637 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.4269/ajtmh.2005.72.675 |
identifier_str_mv |
CERÁVOLO, Isabela P. et al. Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon. American Journal of Tropical Medicine and Hygiene, v. 72, n. 6, p. 675-681, 2005. DOI: https://doi.org/10.4269/ajtmh.2005.72.675. Disponível em: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.533.3398&rep=rep1&type=pdf. 0002-9637 10.4269/ajtmh.2005.72.675 |
url |
https://patua.iec.gov.br/handle/iec/3577 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
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American Society of Tropical Medicine and Hygiene |
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