Hyperfine interactions measurements in hydroxiapatite: considerations and perspectives

• Autor(a) principal: Leite Neto, Osmar Flávio da Silveira
• Data de Publicação: 2014
• Outros Autores: Saitovitch, Henrique, Cavalcante, José T. P. D., Cavalcante, Fábio H. M., Oliveira, Ralph Santos, Instituto de Engenharia Nuclear (IEN), Centro Brasileiro de Pesquisas Físicas (CBPF), Instituto de Pesquisas Físicas e Energéticas (IPEN)
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional do IEN
• Texto Completo: http://carpedien.ien.gov.br:8080/handle/ien/2756
• topic: Nanoparticles; Bioceramics; Hyperfine interactions

The use of nanoparticles, here enclosed their delivery by specific carriers, in current medicine are under systematic investigation(1). The possible advantages proposed by these systems are very impressive and the results may be quite schemer(2). One of such systems is the Hydroxiapatite (HA) ceramics [Ca10(PO4)6(OH)2], pure and doped with rare-earths, used as carriers for bone treatments in healthcare(3). The synthesized HA is a pure phase that is well established for bone replacement material in orthopedics and dentistry(4). More recently, it's highly active surface started to being used for doping it with several elements, for instance Holmium atoms (Ho), which are introduced in HA during it's sintesization; with the expectation that, because of the HA similarity to bones structures, it could be successfully used as a Ho delivery system in bone's diseases(5). But, these substitutions may provoke, until present unknown, changes in the HA's surface structure and charge, and in such a way influencing it's ability to play it's role on natural bone remodeling processes. In this scenario, it is certainly interesting to enlarge the knowledge of the actions the atoms of the nanosystem's crystalline structures, as well as their changes, dopped or non-dopped, are playing to allow the consequent medical applications. And such changes, which occur in an atomic level can be, even considering the eventual difficulties of such approaches in the case of biological compounds, studied with the so called Hyperfine Interactions (HI)(6). In this study HA nanoparticles, with and without doping Ho atoms, were prepared with diffused isotope-probe 111In in order to use the Time-Differential Perturbed Angular Correlation (TDPAC) nuclear spectroscopy for measuring HI(7).