In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
Texto Completo: | https://doi.org/10.1590/1414-431X2022e11976 https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 |
Resumo: | Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed. |
id |
IFPA-1_5774c004db06a2ec01d592ccecb127de |
---|---|
oai_identifier_str |
oai:10.0.2.15:prefix/352 |
network_acronym_str |
IFPA-1 |
network_name_str |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
repository_id_str |
|
spelling |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercuryMercuryProlactinHistological evaluationBiochemical parameterGenotoxicityCNPQ::CIENCIAS DA SAUDENon-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed.Pró-Reitoria de Pesquisa e Pós-Graduação UFPAInstituto Federal de Educação, Ciência e Tecnologia do ParáBrasil2022-10-19T16:02:03Z2022-10-19T16:02:03Z2022-05-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCUNHA, L.; BOFIM, L.; LIMA, G.; SILVA, R.; SILVA, L.; LIMA, P.; OLIVEIRA-BAHIA, V; FREITAS, J.; BURBANO, R.; ROCHA, C. In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury. Brazilian Journal of Medical and Biological Research, v. 55, n. e11976. 2022. Disponível em: https://repositorio.ifpa.edu.br/jspui/handle/prefix/352. Acesso em: .https://doi.org/10.1590/1414-431X2022e119761414-431Xhttps://repositorio.ifpa.edu.br/jspui/handle/prefix/352https://www.scielo.br/j/bjmbr/a/sNB6FPw4GjqmMnJqrSL7bBK/?lang=enreponame:Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)instname:Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)instacron:IFPAengBrazilian Journal of Medical and Biological ResearchCUNHA, Lorena Araújo daBOFIM, LLIMA, GSILVA, RSILVA, LLIMA, POLIVEIRA-BAHIA, Veronica Regina Lobato deFREITAS, JBURBANO, Rommel Mario RodríguezROCHA, Carlos Alberto Machado dainfo:eu-repo/semantics/openAccess2023-06-28T18:27:04Zoai:10.0.2.15:prefix/352Repositório InstitucionalPUBhttps://repositorio.ifpa.edu.br/oai/requestrepositorio@ifpa.edu.bropendoar:2023-06-28T18:27:04Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) - Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA)false |
dc.title.none.fl_str_mv |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
title |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
spellingShingle |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury CUNHA, Lorena Araújo da Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE |
title_short |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
title_full |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
title_fullStr |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
title_full_unstemmed |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
title_sort |
In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury |
author |
CUNHA, Lorena Araújo da |
author_facet |
CUNHA, Lorena Araújo da BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da |
author_role |
author |
author2 |
BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
CUNHA, Lorena Araújo da BOFIM, L LIMA, G SILVA, R SILVA, L LIMA, P OLIVEIRA-BAHIA, Veronica Regina Lobato de FREITAS, J BURBANO, Rommel Mario Rodríguez ROCHA, Carlos Alberto Machado da |
dc.subject.por.fl_str_mv |
Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE |
topic |
Mercury Prolactin Histological evaluation Biochemical parameter Genotoxicity CNPQ::CIENCIAS DA SAUDE |
description |
Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus. Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-19T16:02:03Z 2022-10-19T16:02:03Z 2022-05-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
CUNHA, L.; BOFIM, L.; LIMA, G.; SILVA, R.; SILVA, L.; LIMA, P.; OLIVEIRA-BAHIA, V; FREITAS, J.; BURBANO, R.; ROCHA, C. In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury. Brazilian Journal of Medical and Biological Research, v. 55, n. e11976. 2022. Disponível em: https://repositorio.ifpa.edu.br/jspui/handle/prefix/352. Acesso em: . https://doi.org/10.1590/1414-431X2022e11976 1414-431X https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 |
identifier_str_mv |
CUNHA, L.; BOFIM, L.; LIMA, G.; SILVA, R.; SILVA, L.; LIMA, P.; OLIVEIRA-BAHIA, V; FREITAS, J.; BURBANO, R.; ROCHA, C. In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury. Brazilian Journal of Medical and Biological Research, v. 55, n. e11976. 2022. Disponível em: https://repositorio.ifpa.edu.br/jspui/handle/prefix/352. Acesso em: . 1414-431X |
url |
https://doi.org/10.1590/1414-431X2022e11976 https://repositorio.ifpa.edu.br/jspui/handle/prefix/352 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Brasil |
dc.source.none.fl_str_mv |
https://www.scielo.br/j/bjmbr/a/sNB6FPw4GjqmMnJqrSL7bBK/?lang=en reponame:Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) instname:Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) instacron:IFPA |
instname_str |
Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
instacron_str |
IFPA |
institution |
IFPA |
reponame_str |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
collection |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
repository.name.fl_str_mv |
Repositório Institucional do Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) - Instituto Federal de Educação, Ciência e Tecnologia do Pará (IFPA) |
repository.mail.fl_str_mv |
repositorio@ifpa.edu.br |
_version_ |
1795322688177176576 |