Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100231 |
Resumo: | ABSTRACT Objective: To evaluate the effects of photobiomodulation therapy in redox status, angiogenesis marker – vascular endothelial growth factor – and in the functional recovery in denervated muscle. Methods: A total of 32 female Wistar rats underwent a crush injury and were randomly divided into four groups: Light Emitting Diode Group 2 and Control Group 2 (muscle collected 2 days after injury), and Light Emitting Diode Group 21 and Control Group 21 (muscle collected 21 days afterinjury). Light Emitting Diode Group 2 and Light Emitting Diode Group 21 received two and ten light emitting diode applications (630±20nm, 9J/cm2, 300mW), respectively, and the Control Group 2 and Control Group 21 did not receive any treatment. The function was evaluated by grasping test at four moments (pre-injury, 2, 10 and 21 post-injury days). The flexor digitorum muscle was collected for analysis of immunolocalization of vascular endothelial growth factor and redox parameters. Results: Functional improvement was observed at the second and tenth post-injury day in treated groups compared to control (p<0.005). The muscle tissue of treated groups presented higher immunohistochemical expression of vascular endothelial growth factor. Photobiomodulation therapy decreased the oxidative damage to lipid in Light Emitting Diode Group 2 compared to Control Group 2 (p=0.023) in the denervated muscle. Conclusion: Photobiomodulation therapy accelerated the functional recovery, increased angiogenesis and reduced lipid peroxidation in the denervated muscle at 2 days after injury. |
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Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of ratsMusclesCrush injuriesPhototherapyOxidative stressVascular endothelial growth factorsMuscle strengthRats, WistarABSTRACT Objective: To evaluate the effects of photobiomodulation therapy in redox status, angiogenesis marker – vascular endothelial growth factor – and in the functional recovery in denervated muscle. Methods: A total of 32 female Wistar rats underwent a crush injury and were randomly divided into four groups: Light Emitting Diode Group 2 and Control Group 2 (muscle collected 2 days after injury), and Light Emitting Diode Group 21 and Control Group 21 (muscle collected 21 days afterinjury). Light Emitting Diode Group 2 and Light Emitting Diode Group 21 received two and ten light emitting diode applications (630±20nm, 9J/cm2, 300mW), respectively, and the Control Group 2 and Control Group 21 did not receive any treatment. The function was evaluated by grasping test at four moments (pre-injury, 2, 10 and 21 post-injury days). The flexor digitorum muscle was collected for analysis of immunolocalization of vascular endothelial growth factor and redox parameters. Results: Functional improvement was observed at the second and tenth post-injury day in treated groups compared to control (p<0.005). The muscle tissue of treated groups presented higher immunohistochemical expression of vascular endothelial growth factor. Photobiomodulation therapy decreased the oxidative damage to lipid in Light Emitting Diode Group 2 compared to Control Group 2 (p=0.023) in the denervated muscle. Conclusion: Photobiomodulation therapy accelerated the functional recovery, increased angiogenesis and reduced lipid peroxidation in the denervated muscle at 2 days after injury.Instituto Israelita de Ensino e Pesquisa Albert Einstein2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100231einstein (São Paulo) v.19 2021reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2021ao6001info:eu-repo/semantics/openAccessNascimento,Jéssica Junia Aparecida CardosoMachado,Alex Sander DiasDella-Santa,Giovanna Moura LamasFernandes,Danielle CristinaFerreira,Marcílio CoelhoMachado,Gustavo Augusto PereiraChaves,Bruna Carolina GarciaCosta,Karine BeatrizRocha-Vieira,EtelOliveira,Murilo XavierGaiad,Thais PeixotoSantos,Ana Paulaeng2021-09-21T00:00:00Zoai:scielo:S1679-45082021000100231Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2021-09-21T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
title |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
spellingShingle |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats Nascimento,Jéssica Junia Aparecida Cardoso Muscles Crush injuries Phototherapy Oxidative stress Vascular endothelial growth factors Muscle strength Rats, Wistar |
title_short |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
title_full |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
title_fullStr |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
title_full_unstemmed |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
title_sort |
Effects of photobiomodulation therapy on functional recovery, angiogenesis and redox status in denervated muscle of rats |
author |
Nascimento,Jéssica Junia Aparecida Cardoso |
author_facet |
Nascimento,Jéssica Junia Aparecida Cardoso Machado,Alex Sander Dias Della-Santa,Giovanna Moura Lamas Fernandes,Danielle Cristina Ferreira,Marcílio Coelho Machado,Gustavo Augusto Pereira Chaves,Bruna Carolina Garcia Costa,Karine Beatriz Rocha-Vieira,Etel Oliveira,Murilo Xavier Gaiad,Thais Peixoto Santos,Ana Paula |
author_role |
author |
author2 |
Machado,Alex Sander Dias Della-Santa,Giovanna Moura Lamas Fernandes,Danielle Cristina Ferreira,Marcílio Coelho Machado,Gustavo Augusto Pereira Chaves,Bruna Carolina Garcia Costa,Karine Beatriz Rocha-Vieira,Etel Oliveira,Murilo Xavier Gaiad,Thais Peixoto Santos,Ana Paula |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento,Jéssica Junia Aparecida Cardoso Machado,Alex Sander Dias Della-Santa,Giovanna Moura Lamas Fernandes,Danielle Cristina Ferreira,Marcílio Coelho Machado,Gustavo Augusto Pereira Chaves,Bruna Carolina Garcia Costa,Karine Beatriz Rocha-Vieira,Etel Oliveira,Murilo Xavier Gaiad,Thais Peixoto Santos,Ana Paula |
dc.subject.por.fl_str_mv |
Muscles Crush injuries Phototherapy Oxidative stress Vascular endothelial growth factors Muscle strength Rats, Wistar |
topic |
Muscles Crush injuries Phototherapy Oxidative stress Vascular endothelial growth factors Muscle strength Rats, Wistar |
description |
ABSTRACT Objective: To evaluate the effects of photobiomodulation therapy in redox status, angiogenesis marker – vascular endothelial growth factor – and in the functional recovery in denervated muscle. Methods: A total of 32 female Wistar rats underwent a crush injury and were randomly divided into four groups: Light Emitting Diode Group 2 and Control Group 2 (muscle collected 2 days after injury), and Light Emitting Diode Group 21 and Control Group 21 (muscle collected 21 days afterinjury). Light Emitting Diode Group 2 and Light Emitting Diode Group 21 received two and ten light emitting diode applications (630±20nm, 9J/cm2, 300mW), respectively, and the Control Group 2 and Control Group 21 did not receive any treatment. The function was evaluated by grasping test at four moments (pre-injury, 2, 10 and 21 post-injury days). The flexor digitorum muscle was collected for analysis of immunolocalization of vascular endothelial growth factor and redox parameters. Results: Functional improvement was observed at the second and tenth post-injury day in treated groups compared to control (p<0.005). The muscle tissue of treated groups presented higher immunohistochemical expression of vascular endothelial growth factor. Photobiomodulation therapy decreased the oxidative damage to lipid in Light Emitting Diode Group 2 compared to Control Group 2 (p=0.023) in the denervated muscle. Conclusion: Photobiomodulation therapy accelerated the functional recovery, increased angiogenesis and reduced lipid peroxidation in the denervated muscle at 2 days after injury. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100231 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100231 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.31744/einstein_journal/2021ao6001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.19 2021 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129910581755904 |