Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200136 |
Resumo: | ABSTRACT Objective To investigate the inter-relation between high sensitivity C-reactive protein and glycated hemoglobin in prediction of risk of obstructive sleep apnea. Methods We included all individuals participating in a check-up program at the Preventive Medicine Center of Hospital Israelita Albert Einstein in 2014. The Berlin questionnaire for risk of obstructive sleep apnea was used, and the high sensitivity C-reactive protein and glycated hemoglobin levels were evaluated. Results The sample included 7,115 participants (age 43.4±9.6 years, 24.4% women). The Berlin questionnaire showed changes in 434 (6.1%) individuals. This finding was associated with high sensitivity C-reactive protein and glycated hemoglobin levels (p<0.001). However, only the association between the Berlin questionnaire result and glycated hemoglobin remained significant in the adjusted multivariate analysis, for the traditional risk factors and for an additional model, including high-density lipoprotein cholesterol and triglycerides. Conclusion The glycated hemoglobin, even below the threshold for diagnosis of diabetes, is independently associated with obstructive sleep apnea syndrome, even after adjustment for obesity and C-reactive protein. These findings suggest a possible pathophysiological link between changes in insulin resistance and obstructive sleep apnea syndrome, independently from obesity or low-grade inflammation. |
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Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndromeSleep apnea, obstructiveHemoglobin A, glycosylatedCardiovascular diseasesInflammationABSTRACT Objective To investigate the inter-relation between high sensitivity C-reactive protein and glycated hemoglobin in prediction of risk of obstructive sleep apnea. Methods We included all individuals participating in a check-up program at the Preventive Medicine Center of Hospital Israelita Albert Einstein in 2014. The Berlin questionnaire for risk of obstructive sleep apnea was used, and the high sensitivity C-reactive protein and glycated hemoglobin levels were evaluated. Results The sample included 7,115 participants (age 43.4±9.6 years, 24.4% women). The Berlin questionnaire showed changes in 434 (6.1%) individuals. This finding was associated with high sensitivity C-reactive protein and glycated hemoglobin levels (p<0.001). However, only the association between the Berlin questionnaire result and glycated hemoglobin remained significant in the adjusted multivariate analysis, for the traditional risk factors and for an additional model, including high-density lipoprotein cholesterol and triglycerides. Conclusion The glycated hemoglobin, even below the threshold for diagnosis of diabetes, is independently associated with obstructive sleep apnea syndrome, even after adjustment for obesity and C-reactive protein. These findings suggest a possible pathophysiological link between changes in insulin resistance and obstructive sleep apnea syndrome, independently from obesity or low-grade inflammation.Instituto Israelita de Ensino e Pesquisa Albert Einstein2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200136einstein (São Paulo) v.15 n.2 2017reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082017ao3900info:eu-repo/semantics/openAccessD’Aurea,Carolina Vicaria RodriguesCerazi,Bruno Gion de AndradeLaurinavicius,Antonio GabrieleJanovsky,Carolina Castro Porto SilvaConceição,Raquel Dilguerian de OliveiraSantos,Raul DBittencourt,Márcio Sommereng2017-10-16T00:00:00Zoai:scielo:S1679-45082017000200136Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-10-16T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
title |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
spellingShingle |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome D’Aurea,Carolina Vicaria Rodrigues Sleep apnea, obstructive Hemoglobin A, glycosylated Cardiovascular diseases Inflammation |
title_short |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
title_full |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
title_fullStr |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
title_full_unstemmed |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
title_sort |
Association of subclinical inflammation, glycated hemoglobin and risk for obstructive sleep apnea syndrome |
author |
D’Aurea,Carolina Vicaria Rodrigues |
author_facet |
D’Aurea,Carolina Vicaria Rodrigues Cerazi,Bruno Gion de Andrade Laurinavicius,Antonio Gabriele Janovsky,Carolina Castro Porto Silva Conceição,Raquel Dilguerian de Oliveira Santos,Raul D Bittencourt,Márcio Sommer |
author_role |
author |
author2 |
Cerazi,Bruno Gion de Andrade Laurinavicius,Antonio Gabriele Janovsky,Carolina Castro Porto Silva Conceição,Raquel Dilguerian de Oliveira Santos,Raul D Bittencourt,Márcio Sommer |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
D’Aurea,Carolina Vicaria Rodrigues Cerazi,Bruno Gion de Andrade Laurinavicius,Antonio Gabriele Janovsky,Carolina Castro Porto Silva Conceição,Raquel Dilguerian de Oliveira Santos,Raul D Bittencourt,Márcio Sommer |
dc.subject.por.fl_str_mv |
Sleep apnea, obstructive Hemoglobin A, glycosylated Cardiovascular diseases Inflammation |
topic |
Sleep apnea, obstructive Hemoglobin A, glycosylated Cardiovascular diseases Inflammation |
description |
ABSTRACT Objective To investigate the inter-relation between high sensitivity C-reactive protein and glycated hemoglobin in prediction of risk of obstructive sleep apnea. Methods We included all individuals participating in a check-up program at the Preventive Medicine Center of Hospital Israelita Albert Einstein in 2014. The Berlin questionnaire for risk of obstructive sleep apnea was used, and the high sensitivity C-reactive protein and glycated hemoglobin levels were evaluated. Results The sample included 7,115 participants (age 43.4±9.6 years, 24.4% women). The Berlin questionnaire showed changes in 434 (6.1%) individuals. This finding was associated with high sensitivity C-reactive protein and glycated hemoglobin levels (p<0.001). However, only the association between the Berlin questionnaire result and glycated hemoglobin remained significant in the adjusted multivariate analysis, for the traditional risk factors and for an additional model, including high-density lipoprotein cholesterol and triglycerides. Conclusion The glycated hemoglobin, even below the threshold for diagnosis of diabetes, is independently associated with obstructive sleep apnea syndrome, even after adjustment for obesity and C-reactive protein. These findings suggest a possible pathophysiological link between changes in insulin resistance and obstructive sleep apnea syndrome, independently from obesity or low-grade inflammation. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200136 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200136 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082017ao3900 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.15 n.2 2017 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129908768768000 |