Iron overload in Brazilian thalassemic patients
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200165 |
Resumo: | ABSTRACT Objectives: To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* magnetic resonance imaging results with serum ferritin levels and the redox active fraction of labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas. Hepatic iron concentration was determined in liver biopsies of 11 patients and the results were compared with liver T2* magnetic resonance imaging. Results: The mean serum ferritin was 2,676.5 +/- 2,051.7 ng/mL. A fraction of labile plasma iron was abnormal (> 0,6 Units/mL) in 48/83 patients (57%). The mean liver T2* value was 3.91 ± 3.95 ms, suggesting liver siderosis in most patients (92.1%). The mean myocardial T2* value was 24.96 ± 14.17 ms and the incidence of cardiac siderosis (T2* < 20 ms) was 36%, of which 19% (22/115) were severe cases (T2* < 10 ms). The mean pancreas T2* value was 11.12 ± 11.20 ms, and 83.5% of patients had pancreatic iron deposition (T2* < 21 ms). There was significant curvilinear and inverse correlation between liver T2* magnetic resonance imaging and hepatic iron concentration (r= −0.878; p < 0.001) and moderate correlation between pancreas and myocardial T2* MRI (r = 0.546; p < 0.0001). Conclusion: A high rate of hepatic, pancreatic and cardiac impairment by iron overload was demonstrated. Ferritin levels could not predict liver, heart or pancreas iron overload as measured by T2* magnetic resonance imaging. There was no correlation between liver, pancreas, liver and myocardial iron overload, neither between ferritin and fraction of labile plasma iron with liver, heart and pancreas T2* values |
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Iron overload in Brazilian thalassemic patientsBlood transfusionMagnetic resonance imagingBiopsyIron overloadABSTRACT Objectives: To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* magnetic resonance imaging results with serum ferritin levels and the redox active fraction of labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas. Hepatic iron concentration was determined in liver biopsies of 11 patients and the results were compared with liver T2* magnetic resonance imaging. Results: The mean serum ferritin was 2,676.5 +/- 2,051.7 ng/mL. A fraction of labile plasma iron was abnormal (> 0,6 Units/mL) in 48/83 patients (57%). The mean liver T2* value was 3.91 ± 3.95 ms, suggesting liver siderosis in most patients (92.1%). The mean myocardial T2* value was 24.96 ± 14.17 ms and the incidence of cardiac siderosis (T2* < 20 ms) was 36%, of which 19% (22/115) were severe cases (T2* < 10 ms). The mean pancreas T2* value was 11.12 ± 11.20 ms, and 83.5% of patients had pancreatic iron deposition (T2* < 21 ms). There was significant curvilinear and inverse correlation between liver T2* magnetic resonance imaging and hepatic iron concentration (r= −0.878; p < 0.001) and moderate correlation between pancreas and myocardial T2* MRI (r = 0.546; p < 0.0001). Conclusion: A high rate of hepatic, pancreatic and cardiac impairment by iron overload was demonstrated. Ferritin levels could not predict liver, heart or pancreas iron overload as measured by T2* magnetic resonance imaging. There was no correlation between liver, pancreas, liver and myocardial iron overload, neither between ferritin and fraction of labile plasma iron with liver, heart and pancreas T2* valuesInstituto Israelita de Ensino e Pesquisa Albert Einstein2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200165einstein (São Paulo) v.9 n.2 2011reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082011ao1897info:eu-repo/semantics/openAccessAssis,Reijane Alves deKay,Fernando UlianaRosemberg,Laércio AlbertoParma,Alexandre Henrique C.Nomura,Cesar HigaLoggetto,Sandra ReginaAraujo,Aderson da SilvaFabron Junior,AntonioVeríssimo,Mônica Pinheiro de AlmeidaBaldanzi,Giorgio RobertoSteagal,Merula A.Velloso,Claudia Angela Galleni Di SessaEspósito,Breno PanniaNakashima,Sandra SaemiDiniz,Michelli da SilvaTricta,FernandoBaroni,Ronaldo HuebFunari,Marcelo Buarque de GusmãoWood,John C.Ribeiro,Andreza Alice FeitosaHamerschlak,Nelsoneng2017-03-14T00:00:00Zoai:scielo:S1679-45082011000200165Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-03-14T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Iron overload in Brazilian thalassemic patients |
title |
Iron overload in Brazilian thalassemic patients |
spellingShingle |
Iron overload in Brazilian thalassemic patients Assis,Reijane Alves de Blood transfusion Magnetic resonance imaging Biopsy Iron overload |
title_short |
Iron overload in Brazilian thalassemic patients |
title_full |
Iron overload in Brazilian thalassemic patients |
title_fullStr |
Iron overload in Brazilian thalassemic patients |
title_full_unstemmed |
Iron overload in Brazilian thalassemic patients |
title_sort |
Iron overload in Brazilian thalassemic patients |
author |
Assis,Reijane Alves de |
author_facet |
Assis,Reijane Alves de Kay,Fernando Uliana Rosemberg,Laércio Alberto Parma,Alexandre Henrique C. Nomura,Cesar Higa Loggetto,Sandra Regina Araujo,Aderson da Silva Fabron Junior,Antonio Veríssimo,Mônica Pinheiro de Almeida Baldanzi,Giorgio Roberto Steagal,Merula A. Velloso,Claudia Angela Galleni Di Sessa Espósito,Breno Pannia Nakashima,Sandra Saemi Diniz,Michelli da Silva Tricta,Fernando Baroni,Ronaldo Hueb Funari,Marcelo Buarque de Gusmão Wood,John C. Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
author_role |
author |
author2 |
Kay,Fernando Uliana Rosemberg,Laércio Alberto Parma,Alexandre Henrique C. Nomura,Cesar Higa Loggetto,Sandra Regina Araujo,Aderson da Silva Fabron Junior,Antonio Veríssimo,Mônica Pinheiro de Almeida Baldanzi,Giorgio Roberto Steagal,Merula A. Velloso,Claudia Angela Galleni Di Sessa Espósito,Breno Pannia Nakashima,Sandra Saemi Diniz,Michelli da Silva Tricta,Fernando Baroni,Ronaldo Hueb Funari,Marcelo Buarque de Gusmão Wood,John C. Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Assis,Reijane Alves de Kay,Fernando Uliana Rosemberg,Laércio Alberto Parma,Alexandre Henrique C. Nomura,Cesar Higa Loggetto,Sandra Regina Araujo,Aderson da Silva Fabron Junior,Antonio Veríssimo,Mônica Pinheiro de Almeida Baldanzi,Giorgio Roberto Steagal,Merula A. Velloso,Claudia Angela Galleni Di Sessa Espósito,Breno Pannia Nakashima,Sandra Saemi Diniz,Michelli da Silva Tricta,Fernando Baroni,Ronaldo Hueb Funari,Marcelo Buarque de Gusmão Wood,John C. Ribeiro,Andreza Alice Feitosa Hamerschlak,Nelson |
dc.subject.por.fl_str_mv |
Blood transfusion Magnetic resonance imaging Biopsy Iron overload |
topic |
Blood transfusion Magnetic resonance imaging Biopsy Iron overload |
description |
ABSTRACT Objectives: To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* magnetic resonance imaging results with serum ferritin levels and the redox active fraction of labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas. Hepatic iron concentration was determined in liver biopsies of 11 patients and the results were compared with liver T2* magnetic resonance imaging. Results: The mean serum ferritin was 2,676.5 +/- 2,051.7 ng/mL. A fraction of labile plasma iron was abnormal (> 0,6 Units/mL) in 48/83 patients (57%). The mean liver T2* value was 3.91 ± 3.95 ms, suggesting liver siderosis in most patients (92.1%). The mean myocardial T2* value was 24.96 ± 14.17 ms and the incidence of cardiac siderosis (T2* < 20 ms) was 36%, of which 19% (22/115) were severe cases (T2* < 10 ms). The mean pancreas T2* value was 11.12 ± 11.20 ms, and 83.5% of patients had pancreatic iron deposition (T2* < 21 ms). There was significant curvilinear and inverse correlation between liver T2* magnetic resonance imaging and hepatic iron concentration (r= −0.878; p < 0.001) and moderate correlation between pancreas and myocardial T2* MRI (r = 0.546; p < 0.0001). Conclusion: A high rate of hepatic, pancreatic and cardiac impairment by iron overload was demonstrated. Ferritin levels could not predict liver, heart or pancreas iron overload as measured by T2* magnetic resonance imaging. There was no correlation between liver, pancreas, liver and myocardial iron overload, neither between ferritin and fraction of labile plasma iron with liver, heart and pancreas T2* values |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200165 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000200165 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082011ao1897 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.9 n.2 2011 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
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IIEPAE |
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IIEPAE |
reponame_str |
Einstein (São Paulo) |
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Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
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||revista@einstein.br |
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1752129906198708224 |