Liver transplant outcome: a comparison between high and low MELD score recipients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000100012 |
Resumo: | OBJECTIVE: To compare low and high MELD scores and investigate whether existing renal dysfunction has an effect on transplant outcome. METHODS: Data was prospectively collected among 237 liver transplants (216 patients) between March 2003 and March 2009. Patients with cirrhotic disease submitted to transplantation were divided into three groups: MELD > 30, MELD < 30, and hepatocellular carcinoma. Renal failure was defined as a ± 25% decline in estimated glomerular filtration rate as observed 1 week after the transplant. Median MELD scores were 35, 21, and 13 for groups MELD > 30, MELD < 30, and hepatocellular carcinoma, respectively. RESULTS: Recipients with MELD > 30 had more days in Intensive Care Unit, longer hospital stay, and received more blood product transfusions. Moreover, their renal function improved after liver transplant. All other groups presented with impairment of renal function. Mortality was similar in all groups, but renal function was the most important variable associated with morbidity and length of hospital stay. CONCLUSION: High MELD score recipients had an improvement in the glomerular filtration rate after 1 week of liver transplantation. |
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Liver transplant outcome: a comparison between high and low MELD score recipientsLiver transplantationEnd stage liver diseaseSeverity of illness indexRenal insufficiencyGlomerular filtration rateTreatment outcomeOBJECTIVE: To compare low and high MELD scores and investigate whether existing renal dysfunction has an effect on transplant outcome. METHODS: Data was prospectively collected among 237 liver transplants (216 patients) between March 2003 and March 2009. Patients with cirrhotic disease submitted to transplantation were divided into three groups: MELD > 30, MELD < 30, and hepatocellular carcinoma. Renal failure was defined as a ± 25% decline in estimated glomerular filtration rate as observed 1 week after the transplant. Median MELD scores were 35, 21, and 13 for groups MELD > 30, MELD < 30, and hepatocellular carcinoma, respectively. RESULTS: Recipients with MELD > 30 had more days in Intensive Care Unit, longer hospital stay, and received more blood product transfusions. Moreover, their renal function improved after liver transplant. All other groups presented with impairment of renal function. Mortality was similar in all groups, but renal function was the most important variable associated with morbidity and length of hospital stay. CONCLUSION: High MELD score recipients had an improvement in the glomerular filtration rate after 1 week of liver transplantation.Instituto Israelita de Ensino e Pesquisa Albert Einstein2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000100012einstein (São Paulo) v.10 n.1 2012reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/S1679-45082012000100012info:eu-repo/semantics/openAccessDavid,Andre IbrahimCoelho,Maria Paula VillelaPaes,Ângela TavaresLeite,Ana KoberDella Guardia,BiancaAlmeida,Márcio Dias deMeira,Sergio PaivaRezende,Marcelo Bruno deAfonso,Rogerio CarballoFerraz-Neto,Ben-Hureng2012-09-19T00:00:00Zoai:scielo:S1679-45082012000100012Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2012-09-19T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Liver transplant outcome: a comparison between high and low MELD score recipients |
title |
Liver transplant outcome: a comparison between high and low MELD score recipients |
spellingShingle |
Liver transplant outcome: a comparison between high and low MELD score recipients David,Andre Ibrahim Liver transplantation End stage liver disease Severity of illness index Renal insufficiency Glomerular filtration rate Treatment outcome |
title_short |
Liver transplant outcome: a comparison between high and low MELD score recipients |
title_full |
Liver transplant outcome: a comparison between high and low MELD score recipients |
title_fullStr |
Liver transplant outcome: a comparison between high and low MELD score recipients |
title_full_unstemmed |
Liver transplant outcome: a comparison between high and low MELD score recipients |
title_sort |
Liver transplant outcome: a comparison between high and low MELD score recipients |
author |
David,Andre Ibrahim |
author_facet |
David,Andre Ibrahim Coelho,Maria Paula Villela Paes,Ângela Tavares Leite,Ana Kober Della Guardia,Bianca Almeida,Márcio Dias de Meira,Sergio Paiva Rezende,Marcelo Bruno de Afonso,Rogerio Carballo Ferraz-Neto,Ben-Hur |
author_role |
author |
author2 |
Coelho,Maria Paula Villela Paes,Ângela Tavares Leite,Ana Kober Della Guardia,Bianca Almeida,Márcio Dias de Meira,Sergio Paiva Rezende,Marcelo Bruno de Afonso,Rogerio Carballo Ferraz-Neto,Ben-Hur |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
David,Andre Ibrahim Coelho,Maria Paula Villela Paes,Ângela Tavares Leite,Ana Kober Della Guardia,Bianca Almeida,Márcio Dias de Meira,Sergio Paiva Rezende,Marcelo Bruno de Afonso,Rogerio Carballo Ferraz-Neto,Ben-Hur |
dc.subject.por.fl_str_mv |
Liver transplantation End stage liver disease Severity of illness index Renal insufficiency Glomerular filtration rate Treatment outcome |
topic |
Liver transplantation End stage liver disease Severity of illness index Renal insufficiency Glomerular filtration rate Treatment outcome |
description |
OBJECTIVE: To compare low and high MELD scores and investigate whether existing renal dysfunction has an effect on transplant outcome. METHODS: Data was prospectively collected among 237 liver transplants (216 patients) between March 2003 and March 2009. Patients with cirrhotic disease submitted to transplantation were divided into three groups: MELD > 30, MELD < 30, and hepatocellular carcinoma. Renal failure was defined as a ± 25% decline in estimated glomerular filtration rate as observed 1 week after the transplant. Median MELD scores were 35, 21, and 13 for groups MELD > 30, MELD < 30, and hepatocellular carcinoma, respectively. RESULTS: Recipients with MELD > 30 had more days in Intensive Care Unit, longer hospital stay, and received more blood product transfusions. Moreover, their renal function improved after liver transplant. All other groups presented with impairment of renal function. Mortality was similar in all groups, but renal function was the most important variable associated with morbidity and length of hospital stay. CONCLUSION: High MELD score recipients had an improvement in the glomerular filtration rate after 1 week of liver transplantation. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000100012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082012000100012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1679-45082012000100012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.10 n.1 2012 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129906331877376 |