Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes

Detalhes bibliográficos
Autor(a) principal: Alves,Amanda Soares
Data de Publicação: 2019
Outros Autores: Bueno,Valquiria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000200600
Resumo: ABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of naïve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose of this article is to clarify each of these changes, aiming to minimize limitations of immunosenescence. If such associations can be established, these cells may be used as early and less invasive markers of aging-related diseases, as well as to indicate interventions, evaluate the efficacy of interventions and be a tool to achieve longevity with quality of life.
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spelling Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changesImmunosenescenceT-lymphocytesInflammationMyeloid-derived suppressor cellsAgingABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of naïve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose of this article is to clarify each of these changes, aiming to minimize limitations of immunosenescence. If such associations can be established, these cells may be used as early and less invasive markers of aging-related diseases, as well as to indicate interventions, evaluate the efficacy of interventions and be a tool to achieve longevity with quality of life.Instituto Israelita de Ensino e Pesquisa Albert Einstein2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000200600einstein (São Paulo) v.17 n.2 2019reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2019rb4733info:eu-repo/semantics/openAccessAlves,Amanda SoaresBueno,Valquiriaeng2019-04-29T00:00:00Zoai:scielo:S1679-45082019000200600Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2019-04-29T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
title Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
spellingShingle Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
Alves,Amanda Soares
Immunosenescence
T-lymphocytes
Inflammation
Myeloid-derived suppressor cells
Aging
title_short Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
title_full Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
title_fullStr Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
title_full_unstemmed Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
title_sort Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
author Alves,Amanda Soares
author_facet Alves,Amanda Soares
Bueno,Valquiria
author_role author
author2 Bueno,Valquiria
author2_role author
dc.contributor.author.fl_str_mv Alves,Amanda Soares
Bueno,Valquiria
dc.subject.por.fl_str_mv Immunosenescence
T-lymphocytes
Inflammation
Myeloid-derived suppressor cells
Aging
topic Immunosenescence
T-lymphocytes
Inflammation
Myeloid-derived suppressor cells
Aging
description ABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of naïve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose of this article is to clarify each of these changes, aiming to minimize limitations of immunosenescence. If such associations can be established, these cells may be used as early and less invasive markers of aging-related diseases, as well as to indicate interventions, evaluate the efficacy of interventions and be a tool to achieve longevity with quality of life.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000200600
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000200600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.31744/einstein_journal/2019rb4733
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.17 n.2 2019
reponame:Einstein (São Paulo)
instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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