Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200186 |
Resumo: | ABSTRACT Objective To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle. |
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Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injuryMuscle, skeletalMuscle denervationPeripheral nerve injuriesRehabilitationBiological productsABSTRACT Objective To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle.Instituto Israelita de Ensino e Pesquisa Albert Einstein2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200186einstein (São Paulo) v.15 n.2 2017reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082017ao3967info:eu-repo/semantics/openAccessPeretti,Ana LuizaAntunes,Juliana SobralLovison,KeliKunz,Regina InêsCastor,Lidyane Regina GomesBrancalhão,Rose Meire CostaBertolini,Gladson Ricardo FlorRibeiro,Lucinéia de Fátima Chaskoeng2017-10-16T00:00:00Zoai:scielo:S1679-45082017000200186Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2017-10-16T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
title |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
spellingShingle |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury Peretti,Ana Luiza Muscle, skeletal Muscle denervation Peripheral nerve injuries Rehabilitation Biological products |
title_short |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
title_full |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
title_fullStr |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
title_full_unstemmed |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
title_sort |
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury |
author |
Peretti,Ana Luiza |
author_facet |
Peretti,Ana Luiza Antunes,Juliana Sobral Lovison,Keli Kunz,Regina Inês Castor,Lidyane Regina Gomes Brancalhão,Rose Meire Costa Bertolini,Gladson Ricardo Flor Ribeiro,Lucinéia de Fátima Chasko |
author_role |
author |
author2 |
Antunes,Juliana Sobral Lovison,Keli Kunz,Regina Inês Castor,Lidyane Regina Gomes Brancalhão,Rose Meire Costa Bertolini,Gladson Ricardo Flor Ribeiro,Lucinéia de Fátima Chasko |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Peretti,Ana Luiza Antunes,Juliana Sobral Lovison,Keli Kunz,Regina Inês Castor,Lidyane Regina Gomes Brancalhão,Rose Meire Costa Bertolini,Gladson Ricardo Flor Ribeiro,Lucinéia de Fátima Chasko |
dc.subject.por.fl_str_mv |
Muscle, skeletal Muscle denervation Peripheral nerve injuries Rehabilitation Biological products |
topic |
Muscle, skeletal Muscle denervation Peripheral nerve injuries Rehabilitation Biological products |
description |
ABSTRACT Objective To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200186 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082017000200186 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082017ao3967 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.15 n.2 2017 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
_version_ |
1752129908783448064 |