Talassemia e hanseniase

Detalhes bibliográficos
Autor(a) principal: RAMALHO, Antonio Sérgio
Data de Publicação: 1983
Outros Autores: PINTO JÚNIOR, Walter, MAGNA, Luis Alberto, BEIGUELMAN, Bernardo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Hansenologia Internationalis (Online)
Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35590
Resumo: The β thalassemia trait was investigated among 165 Brazilians who were unmixed Italian descendants (80 Virchowian patients and 85 normal controls, composed of universitary students). The frequency of the p-thalassemia trait was 6.25% among the Virchowian patients and 5.88% in the control group. In spite of the similar geographical distribution of both hanseniasis and the gene for p-thalassemia in Asia, the present data does not support the hypothesis that hanseniasis might have contributed to maintain high prevalence of this allele by selection favouring fl-thalassemia trait.
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spelling Talassemia e hanseniaseTalassemia βHanseníaseHemoglobinas anormaisp-thalassemiaHanseniasisAbnormal hemoglobinsThe β thalassemia trait was investigated among 165 Brazilians who were unmixed Italian descendants (80 Virchowian patients and 85 normal controls, composed of universitary students). The frequency of the p-thalassemia trait was 6.25% among the Virchowian patients and 5.88% in the control group. In spite of the similar geographical distribution of both hanseniasis and the gene for p-thalassemia in Asia, the present data does not support the hypothesis that hanseniasis might have contributed to maintain high prevalence of this allele by selection favouring fl-thalassemia trait.A talassemia β foi investigada em 165 brasileiros descendentes não miscigenados de italianos, 80 dos quais eram doentes de hanseníase, da forma virchowiana, e 85 estudantes universitários (grupo controle). A freqüência da talassemia foi de 6,25% entre os hansenianos e de 5,88% entre os estudantes. Apesar da similaridade da distribuição geográfica tanto da hanseníase quanto do gene da talassemia p em algumas regiões do globo, sobretudo da Ásia, a freqüência de indivíduos com o estigma talassêmico observada nas amostras analisadas não apoia a hipótese de que a hanseníase possa ter contribuído para manter as altas freqüências desse alelo, por intermédio da seleção a favor dos talassêmicos heterozigotos.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo1983-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3559010.47878/hi.1983.v8.35590Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 8 No. 1 (1983); 61-65Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 8 n. 1 (1983); 61-651982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/35590/33993RAMALHO, Antonio SérgioPINTO JÚNIOR, WalterMAGNA, Luis AlbertoBEIGUELMAN, Bernardoinfo:eu-repo/semantics/openAccess2021-06-06T04:23:57Zoai:ojs.periodicos.saude.sp.gov.br:article/35590Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2021-06-06T04:23:57Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false
dc.title.none.fl_str_mv Talassemia e hanseniase
title Talassemia e hanseniase
spellingShingle Talassemia e hanseniase
RAMALHO, Antonio Sérgio
Talassemia β
Hanseníase
Hemoglobinas anormais
p-thalassemia
Hanseniasis
Abnormal hemoglobins
title_short Talassemia e hanseniase
title_full Talassemia e hanseniase
title_fullStr Talassemia e hanseniase
title_full_unstemmed Talassemia e hanseniase
title_sort Talassemia e hanseniase
author RAMALHO, Antonio Sérgio
author_facet RAMALHO, Antonio Sérgio
PINTO JÚNIOR, Walter
MAGNA, Luis Alberto
BEIGUELMAN, Bernardo
author_role author
author2 PINTO JÚNIOR, Walter
MAGNA, Luis Alberto
BEIGUELMAN, Bernardo
author2_role author
author
author
dc.contributor.author.fl_str_mv RAMALHO, Antonio Sérgio
PINTO JÚNIOR, Walter
MAGNA, Luis Alberto
BEIGUELMAN, Bernardo
dc.subject.por.fl_str_mv Talassemia β
Hanseníase
Hemoglobinas anormais
p-thalassemia
Hanseniasis
Abnormal hemoglobins
topic Talassemia β
Hanseníase
Hemoglobinas anormais
p-thalassemia
Hanseniasis
Abnormal hemoglobins
description The β thalassemia trait was investigated among 165 Brazilians who were unmixed Italian descendants (80 Virchowian patients and 85 normal controls, composed of universitary students). The frequency of the p-thalassemia trait was 6.25% among the Virchowian patients and 5.88% in the control group. In spite of the similar geographical distribution of both hanseniasis and the gene for p-thalassemia in Asia, the present data does not support the hypothesis that hanseniasis might have contributed to maintain high prevalence of this allele by selection favouring fl-thalassemia trait.
publishDate 1983
dc.date.none.fl_str_mv 1983-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35590
10.47878/hi.1983.v8.35590
url https://periodicos.saude.sp.gov.br/hansenologia/article/view/35590
identifier_str_mv 10.47878/hi.1983.v8.35590
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/hansenologia/article/view/35590/33993
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
publisher.none.fl_str_mv Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo
dc.source.none.fl_str_mv Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 8 No. 1 (1983); 61-65
Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 8 n. 1 (1983); 61-65
1982-5161
reponame:Hansenologia Internationalis (Online)
instname:Instituto Lauro de Souza Lima (ILSL)
instacron:ILSL
instname_str Instituto Lauro de Souza Lima (ILSL)
instacron_str ILSL
institution ILSL
reponame_str Hansenologia Internationalis (Online)
collection Hansenologia Internationalis (Online)
repository.name.fl_str_mv Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)
repository.mail.fl_str_mv hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br
_version_ 1796797579786190848

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