Quantification of serum leptin levels in leprosy
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Hansenologia Internationalis (Online) |
Texto Completo: | https://periodicos.saude.sp.gov.br/hansenologia/article/view/36194 |
Resumo: | Leptin, an adipokine with structural and functional similarities to proinflammatory cytokines that contributes to the differentiation of T helper-1 cells, seems to be involved in the immune response to infectious agents. In leprosy, a chronic infectious disease caused by Mycobacterium leprae, whose clinical manifestations dependon the host immune response, there are no reports on the role of leptin. In this pilot study the serum leptin levels were quantified in newly diagnosed patients with different clinical forms of leprosy, patients with type 1 and 2 reaction, contacts of leprosy patients and healthy controls (237 serum samples:165 men and 72 women). In males, TT and BB patients showed concentrations close to those observed in controls while groups I, BT, BV, VV, type 1 and 2 reactional patients had lower means in comparison to controls and contacts, whereas in BV and VV patients it were observed the lowest levels of leptin. In females, we found a wide variation between the values observed in the different groups. The BV group had higher levels of leptin while groups I, TT, BT and BB had averages closed to that observed in contacts and controls. The differences observed in both men and women were not statistically significant. Our findings show a tendency to lower levels of leptin in multibacillary patients, however, these results do not allow any association of leptin with leprosy clinical forms. |
id |
ILSL-1_eb1f51cca1a0cfeccb5bfcc4822e494f |
---|---|
oai_identifier_str |
oai:ojs.periodicos.saude.sp.gov.br:article/36194 |
network_acronym_str |
ILSL-1 |
network_name_str |
Hansenologia Internationalis (Online) |
repository_id_str |
|
spelling |
Quantification of serum leptin levels in leprosyQuantificação dos níveis séricos de leptina na HanseníaseHanseníaseLeptinaSistema ImunológicoLeprosyLeptinImmune SystemLeptin, an adipokine with structural and functional similarities to proinflammatory cytokines that contributes to the differentiation of T helper-1 cells, seems to be involved in the immune response to infectious agents. In leprosy, a chronic infectious disease caused by Mycobacterium leprae, whose clinical manifestations dependon the host immune response, there are no reports on the role of leptin. In this pilot study the serum leptin levels were quantified in newly diagnosed patients with different clinical forms of leprosy, patients with type 1 and 2 reaction, contacts of leprosy patients and healthy controls (237 serum samples:165 men and 72 women). In males, TT and BB patients showed concentrations close to those observed in controls while groups I, BT, BV, VV, type 1 and 2 reactional patients had lower means in comparison to controls and contacts, whereas in BV and VV patients it were observed the lowest levels of leptin. In females, we found a wide variation between the values observed in the different groups. The BV group had higher levels of leptin while groups I, TT, BT and BB had averages closed to that observed in contacts and controls. The differences observed in both men and women were not statistically significant. Our findings show a tendency to lower levels of leptin in multibacillary patients, however, these results do not allow any association of leptin with leprosy clinical forms.A leptina é uma adipocina com semelhanças estruturais e funcionais às citocinas pró-inflamatórias, contribuindo para a diferenciação de células Th1, e parece estar envolvida na resposta imune a agentes infecciosos. Na hanseníase, doença infecciosa crônica causada pelo Mycobacterium leprae, cujas manifestações clínicas dependem da resposta imune do hospedeiro, não há relatos sobre o papel da leptina. Neste estudo piloto foram quantificados os níveis séricos de leptina em pacientes recém-diagnosticados com as diferentes formas clínicas da doença, pacientes hansenianos em reação tipo 1 e 2, contatos de pacientes hansenianos e controles saudáveis (237 amostras de soros: 165 homens e 72 mulheres). No sexo masculino, as formas TT e BB apresentaram concentrações próximas àquelas observadas nos controles enquanto os grupos I, BT, BV, VV, reação do tipo 1 e 2 apresentaram médias inferiores à observada nos controles e contatos, sendo que nos BV e VV foram observados os menores níveis de leptina. No sexo feminino verificamos uma grande variação entre os valores observados nos diferentes grupos. O grupo BV apresentou níveis maiores de leptina enquanto os grupos I, TT, BT e BB apresentaram média próxima àquela observada nos contatos e controles. Pacientes do grupo VV e em reação tipo 1 e 2 apresentaram médias inferiores ao observado nos contatos e controles. As diferenças observadas tanto em homens quanto em mulheres não foram estatisticamente significantes. Em nossos achados há uma tendência a níveis mais baixos de leptina nas formas multibacilares, contudo, estes resultados não permitem associação desses níveis com qualquer forma clínica da hanseníase.Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo2012-11-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/3619410.47878/hi.2012.v37.36194Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 37 No. 2 (2012); 40-46Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 37 n. 2 (2012); 40-461982-5161reponame:Hansenologia Internationalis (Online)instname:Instituto Lauro de Souza Lima (ILSL)instacron:ILSLporhttps://periodicos.saude.sp.gov.br/hansenologia/article/view/36194/34500https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMacedo, Alexandre Casimiro deGigliotti, PatríciaGameiro, JacySouza, Vânia Nieto Brito de2023-01-18T17:45:28Zoai:ojs.periodicos.saude.sp.gov.br:article/36194Revistahttps://periodicos.saude.sp.gov.br/hansenologiaPRIhttps://periodicos.saude.sp.gov.br/hansenologia/oaihansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br1982-51610100-3283opendoar:2023-01-18T17:45:28Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL)false |
dc.title.none.fl_str_mv |
Quantification of serum leptin levels in leprosy Quantificação dos níveis séricos de leptina na Hanseníase |
title |
Quantification of serum leptin levels in leprosy |
spellingShingle |
Quantification of serum leptin levels in leprosy Macedo, Alexandre Casimiro de Hanseníase Leptina Sistema Imunológico Leprosy Leptin Immune System |
title_short |
Quantification of serum leptin levels in leprosy |
title_full |
Quantification of serum leptin levels in leprosy |
title_fullStr |
Quantification of serum leptin levels in leprosy |
title_full_unstemmed |
Quantification of serum leptin levels in leprosy |
title_sort |
Quantification of serum leptin levels in leprosy |
author |
Macedo, Alexandre Casimiro de |
author_facet |
Macedo, Alexandre Casimiro de Gigliotti, Patrícia Gameiro, Jacy Souza, Vânia Nieto Brito de |
author_role |
author |
author2 |
Gigliotti, Patrícia Gameiro, Jacy Souza, Vânia Nieto Brito de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Macedo, Alexandre Casimiro de Gigliotti, Patrícia Gameiro, Jacy Souza, Vânia Nieto Brito de |
dc.subject.por.fl_str_mv |
Hanseníase Leptina Sistema Imunológico Leprosy Leptin Immune System |
topic |
Hanseníase Leptina Sistema Imunológico Leprosy Leptin Immune System |
description |
Leptin, an adipokine with structural and functional similarities to proinflammatory cytokines that contributes to the differentiation of T helper-1 cells, seems to be involved in the immune response to infectious agents. In leprosy, a chronic infectious disease caused by Mycobacterium leprae, whose clinical manifestations dependon the host immune response, there are no reports on the role of leptin. In this pilot study the serum leptin levels were quantified in newly diagnosed patients with different clinical forms of leprosy, patients with type 1 and 2 reaction, contacts of leprosy patients and healthy controls (237 serum samples:165 men and 72 women). In males, TT and BB patients showed concentrations close to those observed in controls while groups I, BT, BV, VV, type 1 and 2 reactional patients had lower means in comparison to controls and contacts, whereas in BV and VV patients it were observed the lowest levels of leptin. In females, we found a wide variation between the values observed in the different groups. The BV group had higher levels of leptin while groups I, TT, BT and BB had averages closed to that observed in contacts and controls. The differences observed in both men and women were not statistically significant. Our findings show a tendency to lower levels of leptin in multibacillary patients, however, these results do not allow any association of leptin with leprosy clinical forms. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36194 10.47878/hi.2012.v37.36194 |
url |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36194 |
identifier_str_mv |
10.47878/hi.2012.v37.36194 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.saude.sp.gov.br/hansenologia/article/view/36194/34500 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
publisher.none.fl_str_mv |
Instituto Lauro de Souza Lima da Secretaria de Estado da Saúde de São Paulo |
dc.source.none.fl_str_mv |
Hansenologia Internationalis: leprosy and other infectious diseases; Vol. 37 No. 2 (2012); 40-46 Hansenologia Internationalis: hanseníase e outras doenças infecciosas; v. 37 n. 2 (2012); 40-46 1982-5161 reponame:Hansenologia Internationalis (Online) instname:Instituto Lauro de Souza Lima (ILSL) instacron:ILSL |
instname_str |
Instituto Lauro de Souza Lima (ILSL) |
instacron_str |
ILSL |
institution |
ILSL |
reponame_str |
Hansenologia Internationalis (Online) |
collection |
Hansenologia Internationalis (Online) |
repository.name.fl_str_mv |
Hansenologia Internationalis (Online) - Instituto Lauro de Souza Lima (ILSL) |
repository.mail.fl_str_mv |
hansen_int@ilsl.br || hansenologia.internationalis@gmail.com || periodicossp@saude.sp.gov.br |
_version_ |
1796797580647071744 |