Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/30609 |
Resumo: | Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts. |
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Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica Oral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection Trypanosoma cruziOral transmissionExperimental intragastric infectionT.cruzi strains infectivityBiodemes Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts. A ocorrência de microepidemias de infecção pelo Trypanosoma cruzi atribuidas à ingestão de alimentos contaminados com excreta de vetores ou de reservatórios vertebrados, em áreas rurais chamou a atenção para este tipo não vetorial de transmissão da doença de Chagas. Considerando que cepas de diferentes biodemas se distribuem diferentemente nos ciclos silvestre e domiciliar de transmissão, a ocorrência de microepidemias predominantes em áreas próximas aos ecótopos silvestres pode estar relacionada com a cepa do parasito, tendo-se em conta a predominância do Biodema Tipo III, Z1 nestas áreas. No presente estudo foi investigada a infectividade de cepas do T. cruzi de diferentes biodemas quando inoculadas por via digestiva. Foi feita inoculação por via intragástrica (VIG) em camundongos Suíços com a cepa Peruana (Biodema Tipo I, Z2b) ou com a Colombiana (Biodema Tipo III, Z1, T. cruzi I). Para controle da infecção, camundongos foram também inoculados por via intraperitoneal (VIP). A cepa Colombiana mostrou alta infectividade e patogenicidade tanto por VIP como por VIG. A cepa Peruana apresentou alta infectividade e patogenicidade pela VIP e mostrou baixa infectividade pela VIG. A mais elevada infectividade pela VIG, da cepa Colombiana, cujo biodema Tipo III, Z1 é o mais freqüentemente encontrado nos hospedeiros silvestres, está de acordo com a ocorrência dos episódios epidêmicos registrados na literatura. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30609Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 2 (2002); 97-103 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 2 (2002); 97-103 Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 2 (2002); 97-103 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30609/32493Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessCAMANDAROBA, Edson Luiz P.PINHEIRO LIMA, Clarissa M.ANDRADE, Sonia G.2012-07-07T17:51:29Zoai:revistas.usp.br:article/30609Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:23.392990Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica Oral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection |
title |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
spellingShingle |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica CAMANDAROBA, Edson Luiz P. Trypanosoma cruzi Oral transmission Experimental intragastric infection T.cruzi strains infectivity Biodemes |
title_short |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
title_full |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
title_fullStr |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
title_full_unstemmed |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
title_sort |
Transmissão oral da doença de Chagas: importância do biodema do Trypanosoma cruzi na infecção experimental intragástrica |
author |
CAMANDAROBA, Edson Luiz P. |
author_facet |
CAMANDAROBA, Edson Luiz P. PINHEIRO LIMA, Clarissa M. ANDRADE, Sonia G. |
author_role |
author |
author2 |
PINHEIRO LIMA, Clarissa M. ANDRADE, Sonia G. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
CAMANDAROBA, Edson Luiz P. PINHEIRO LIMA, Clarissa M. ANDRADE, Sonia G. |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Oral transmission Experimental intragastric infection T.cruzi strains infectivity Biodemes |
topic |
Trypanosoma cruzi Oral transmission Experimental intragastric infection T.cruzi strains infectivity Biodemes |
description |
Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/30609 |
url |
https://www.revistas.usp.br/rimtsp/article/view/30609 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/30609/32493 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 2 (2002); 97-103 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 2 (2002); 97-103 Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 2 (2002); 97-103 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951643429994496 |